Neural correlates of cognitive motor signals in primary somatosensory cortex
Classical systems neuroscience positions primary sensory areas as early feed-forward processing stations for refining incoming sensory information. This view may oversimplify their role given extensive bi-directional connectivity with multimodal cortical and subcortical regions. Here we show that single units in human primary somatosensory cortex encode imagined reaches centered on imagined limb positions in a cognitive motor task. This result suggests a broader role of primary somatosensory cortex in cortical function than previously demonstrated.
Additional InformationThe copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Posted April 21, 2020. This work was supported by the National Institute of Health (R01EY015545, 5U01NS098975-02), the Tianqiao and Chrissy Chen Brain-machine Interface Center at Caltech, the Conte Center for Social Decision Making at Caltech (P50MH094258), the David Geffen Medical Scholarship, and the Boswell Foundation. The authors would also like to thank subject FG for participating in the studies, and Viktor Scherbatyuk for technical assistance. Author Contributions: M.J., T.A, and R.A.A designed the study, M.J. and T.A developed experimental tasks, M.J. and T.A. designed analysis and analyzed the data, M.J., S.C., S.S.K, and M.A.S. collected the data, S.L.N contributed code, M.J. and T.A. interpreted results and wrote the original draft, M.J., T.A., S.C., and R.A.A. reviewed and edited the paper, T.A. and R.A.A. provided mentorship, T.A., S.K., and R.A.A. acquired funding, K.P provided administrative and regulatory assistance, C.Y.L. performed implantation surgery. Data availability: All primary behavioral and neurophysiological data are archived in the Division of Biology and Biological Engineering at the California Institute of Technology and are available from the corresponding author on reasonable request. Code availability: All custom-written analysis code is available from the corresponding author on reasonable request.
Submitted - 2020.04.20.041269v1.full.pdf
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