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Published June 2017 | Supplemental Material + Accepted Version
Journal Article Open

High-speed photoacoustic microscopy of mouse cortical microhemodynamics


We applied high‐speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer‐level optical resolution and a millisecond‐level cross‐sectional imaging speed over a millimeter‐level field of view. We monitored blood flow redistribution in mini‐stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high‐speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

Additional Information

© 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. Received 9 September 2016, revised 28 November 2016, accepted 7 December 2016, Published online 24 December 2016. The authors appreciate Prof. James Ballard's close reading of the manuscript. We also thank Peng Hu for image processing. This work was sponsored by NIH grants R01 CA186567 (NIH Director's Transformative Research Award), and R01 CA159959 (for L. V. Wang), and NSF grant IDBR‐1255921 (for J. Zou). L. V. Wang has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.

Attached Files

Accepted Version - nihms889382.pdf

Supplemental Material - jbio201600236-sup-001-movie1.wmv

Supplemental Material - jbio201600236-sup-002-movie2.wmv

Supplemental Material - jbio201600236-sup-003-movie3.wmv

Supplemental Material - jbio201600236-sup-004-movie4.wmv


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