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Published March 2008 | Published
Journal Article Open

Sentinel lymph node detection ex vivo using ultrasound-modulated optical tomography


We apply ultrasound-modulated optical tomography (UOT) to image ex-vivo methylene-blue-dyed sentinel lymph nodes embedded in 3.2-cm-thick chicken breast tissues. The UOT system is implemented for the first time using ring-shaped light illumination, intense acoustic bursts, and charge-coupled device (CCD) camera-based speckle contrast detection. Since the system is noninvasive, nonionizing, portable, relatively cost effective, and easy to combine with photoacoustic imaging and single element ultrasonic pulse-echo imaging, UOT can potentially be a good imaging modality for the detection of sentinel lymph nodes in breast cancer staging in vivo.

Additional Information

© 2008 SPIE. Paper 07492LR received Jan. 3, 2008; revised manuscript received Feb. 18, 2008; accepted for publication Feb. 18, 2008; published online Apr. 21, 2008. This research was supported by NIH grant numbers R33 CA 094267, R01 NS46214, and R01 CA106728.

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