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Published June 2015 | public
Book Section - Chapter

MEMS for single-islet electroisletogram


This paper reports the first MEMS device designed for in vitro measuring of electroisletogram (EIG) of individual rat islets. Using vacuum to hold an islet in proximity to a microelectrode, strong EIG signals in millivolt range are obtained, while the noise is about 100μV pk-pk. This work proves the feasibility of using MEMS and EIG for high-throughput screening, in contrast to patch-clamp measurements, of islets for transplantation to treat diabetes.

Additional Information

© 2015 IEEE. The authors would greatly thank all the members of California Institute of Technology (Caltech) MEMS lab, especially Mr. Trevor Roper for the maintenance of equipment.

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September 15, 2023
October 23, 2023