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Published December 1950 | Published
Journal Article Open

Metabolism of C14-labeled glycine, L-histidine, L-leucine, and L-lysine


A study of the rates of incorporation in vivo of labeled amino acids into tissue proteins was undertaken to find the best time at which intermediates in the process might be found. The rates observed were so fast that we decided to investigate the process in some detail. The amino acids were L-α-aminoadipic-6-C14 acid, glycine-1-C14, L-histidine-2-C14-imidazole, L-leucine-1-C14, and L-lysine-1-C14.

Additional Information

© 1950 American Society of Biological Chemists. Received for publication, July 17, 1950. This work is a part of that done under contract with and joint sponsorship of the United States Atomic Energy Commission and the Office of Naval Research, United States Navy Department. The C14 used in this investigation was supplied by the Carbide and Carbon Chemicals Corporation, Oak Ridge, Tennessee, and obtained on allocation from the United States Atomic Energy Commission.

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August 21, 2023
October 17, 2023