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Published March 19, 2010 | Supplemental Material
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Regioselective Reactions of Highly Substituted Arynes


The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functionalization of aromatic rings.

Additional Information

© 2010 American Chemical Society. Published In Issue: March 19, 2010; article ASAP: February 18, 2010; received: January 12, 2010. The authors thank The Gordon and Betty Moore Foundation, Abbott, Amgen, Boehringer- Ingelheim, Bristol-Myers Squibb, Merck, Sigma-Aldrich, Teva USA Scholars grant, The California HIV/AIDS Research Program (fellowship to P.M.T.) and Caltech for generous funding.

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August 19, 2023
October 20, 2023