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Published October 15, 1983 | Published
Journal Article Open

Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse


Chromosomal locations of members of the xenotropic-related env gene family in the mouse genome have been determined. Endonuclease restriction site polymorphisms detected by molecular hybridization were used to study the inheritance of mink cell-focus inducing and xenotropic env gene-related sequences in recombinant inbred strains of mice. Some of the endogenous env sequences appear to be closely linked to genes determining leukemia virus induction and to genes involved in the immune response, such as the heavy and light chains of the immunoglobulin molecules or allotypic determinants on B and T lymphocytes. The use of probes that detect restriction fragment length polymorphisms in a small family of dispersed sequences promises to yield a large number of markers that can be used together with recombinant inbred strains for efficient mapping of the mouse genome.

Additional Information

© 1983 by the National Academy of Sciences. Communicated by Dan L. Lindsley, July 14, 1983. We thank Dr. Marguerite Vogt for the MCF env probe and for helpful discussions. Dr. B.A. Taylor kindly provided a compilation of known SDPs in the B × D mice. We thank Jessica Dausman, Lisa Jahn, and Steve Marks for technical assistance and Michele Platten for manuscript preparation. This work was supported by National Institutes of Health Grant GM29797. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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