Nucleotide Sequence of a Human Immunoglobulin Cγ4 Gene
We report the nucleotide sequence of a gene encoding the constant region of a human immunoglobulin γ4 heavy chain (C_(γ4)). These data represent the first complete sequence determination of a human CH gene. As expected from structural studies of mouse C_γ genes, the coding sequences for the CH domains and hinge segment are separated from one another by intervening DNA sequences. Comparison with genomic sequences of the mouse C_(γ1), C_(γ2a), and C_(γ2b) genes shows conservation of the sequences in the constant region domains and the 3′ untranslated region surrounding the presumed site of poly(A) addition.