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Published October 2017 | Accepted Version
Journal Article Open

Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion


Proper localization of membrane proteins is essential for the function of biological membranes and for the establishment of organelle identity within a cell. Molecular machineries that mediate membrane protein biogenesis need to not only achieve a high degree of efficiency and accuracy, but also prevent off-pathway aggregation events that can be detrimental to cells. The posttranslational targeting of tail-anchored proteins (TAs) provides tractable model systems to probe these fundamental issues. Recent advances in understanding TA-targeting pathways reveal sophisticated molecular machineries that drive and regulate these processes. These findings also suggest how an interconnected network of targeting factors, cochaperones, and quality control machineries together ensures robust membrane protein biogenesis.

Additional Information

© 2017 Annual Reviews. This work was supported by NIH grant GM107368 to S.-o.S. The authors are not aware of any affiliations, memberships, funding, or financial holdings that might be perceived as affecting the objectivity of this review.

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Accepted Version - nihms-1001158.pdf


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August 19, 2023
October 17, 2023