Time-resolved, cell-selective analysis of protein synthesis in complex biological systems

Abstract

The behavior of biol. systems varies in space and time. The BONCAT (bioorthogonal non-canonical amino acid tagging) method provides a means by which investigators can probe the heterogeneous nature of protein synthesis in complex biol. systems, including live animals. This lecture will examine the scope and limitations of the BONCAT method, with examples drawn from neurobiol., cancer biol. and microbiol.

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