Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published November 2013 | Accepted Version
Journal Article Open

A brief account of nanoparticle contrast agents for photoacoustic imaging

Abstract

Photoacoustic imaging (PAI) is a hybrid, nonionizing modality offering excellent spatial resolution, deep penetration, and high soft tissue contrast. In PAI, signal is generated based on the absorption of laser-generated optical energy by endogenous tissues or exogenous contrast agents leading to acoustic emissions detected by an ultrasound transducer. Research in this area over the years has shown that PAI has the ability to provide both physiological and molecular imaging, which can be viewed alone or used in a hybrid modality fashion to extend the anatomic and hemodynamic sensitivities of clinical ultrasound. PAI may be performed using inherent contrast afforded by light absorbing molecules such as hemoglobin, myoglobin, and melanin or exogenous small molecule contrast agent such as near infrared dyes and porphyrins. However, this review summarizes the potential of exogenous nanoparticle-based agents for PAI applications including contrast based on gold particles, carbon nanotubes, and encapsulated copper compounds.

Additional Information

© 2013 Wiley Periodicals, Inc. Version of Record online: 23 AUG 2013. Conflict of interest: L. V. W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc.

Attached Files

Accepted Version - nihms489519.pdf

Files

nihms489519.pdf
Files (10.2 MB)
Name Size Download all
md5:337dd3a5389356f49092b3e2628a0c29
10.2 MB Preview Download

Additional details

Created:
August 19, 2023
Modified:
October 19, 2023