Novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography using carbon nanotubes (CNTs) as a dual contrast agent
We report here a novel breast cancer scanner using microwave and light excitation and ultrasound detection. This combined thermoacoustic and photoacoustic tomography scanner is a nonionizing low cost system that can potentially provide high-resolution, dual contrast (microwave and light absorption) three dimensional images of the breast. Front breast compression will be used in this scanner to alleviate patient discomfort, experienced in side breast compression during traditional X-ray mammography. This scanner will use dry instead of gel ultrasonic coupling. We have also developed a carbon nanotube-based contrast agent for both thermoacoustic and photoacoustic imaging. In the future, targeted molecular photoacoustic and thermoacoustic imaging should be possible using this contrast agent.
Additional Information© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported by National Institutes of Health grants R01 EB000712 and R01 NS046214 (LVW) and the Office of the Vice President of Research at Stony Brook University (SB). The authors would like to thank Dr. Oleg Gang and Dr. Huming Xiong at the Center for Functional Nanomaterials, Brookhaven National Laboratory for access to the AFM, Mr. Tom Salagaj and Mr. Christopher Jensen at FirstNano/CVD Equipment Corporation for access to their CVD facilities and Dr. Eunah Lee at Horiba JvonYvon, Edison, NJ for the Raman Spectroscopy measurements.
Published - 71772G.pdf