Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography
For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) non-invasively and in real time. The PAT system, based on a 512-element full-ring array with cylindrical focusing, received the PA signal primarily from a slice of about 2 mm thickness. This system can provide not only high resolution brain vasculature images but also hemodynamic functional images. We recorded the wash-in process of a photoacoustic contrast agent in a mouse brain in real time. Our results demonstrated that PAT is a powerful imaging modality to study real-time small animal neurofunctional activities that cause changes in hemodynamics.
Additional Information© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank the Yu Wang and Junjie Yao for helpful discussions. This work has been supported in part by National Institutes of Health grants R01 EB000712, R01 EB008085, and U54 CA136398 (Network for Translational Research). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work
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