Migration of glia along photoreceptor axons in the developing drosophila eye
We have identified a set of retinal basal glia, designated RBG cells, in the axon layer of the developing Drosophila eye disc. In vivo pulse labeling with bromodeoxyuridine shows that these cells originate in the optic stalk and migrate into the disc. In mutants lacking photoreceptor axons, RBG cells accumulate in the optic stalk, but do not invade the disc. The association of RBG cells with photoreceptor axons, their origin in the optic stalk, and their migration into the retina are in common with the behavior of astrocytes in the developing mammalian retina.
© 1994 Cell Press. We thank Rosalind Young and Lynette Dowling for expert technical assistance and our colleagues for comments and suggestions on the manuscript. We also thank Gary Belford, of Scott Fraser's Imaging Facility at Caltech, for help with confocal microscopy; Kalpana White for the ELAV antibody; and Andrew Tomlinson for the RK2-5' antibody. This research was supported by a postdoctoral fellowship (to K.-W. C.) from the Drown Foundation and grants (to S. B.) from the National Science Foundation (BCS 8908154), the National Eye Institute of the National Institutes of Health (EY09278), the McKnight Foundation, and the James G. Boswell Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC Section 1734 solely to indicate this fact.