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Published July 15, 1998 | public
Journal Article

Mammalian BarH Homologue Is a Potential Regulator of Neural bHLH Genes


Vertebrate neurogenesis involves sequential actions of transcription factors.neurogenins,encoding Atonal-related bHLH transcription factors, function as neuronal determination genes inXenopus. neurogeninsand another bHLH factor gene,Mash1,are expressed in distinct subsets or areas of cells giving rise to neurons, suggesting that these genes play important roles to generate distinct populations of neurons. A mammalian homologue of BarH(MBH1) is expressed in a complementary pattern to Mash1expression in the developing nervous system likeneurogenins.Forced expression of MBH1down-regulates expression of Mash1and up-regulatesneurogenin2/Math4A, a member of neurogenins,in P19 cells during neuronal differentiation. This suggests thatMBH1is a potential regulator of mammalian neural bHLH genes, thereby establishing distinct pathways of neuronal differentiation.

Additional Information

© 1998 Academic Press. Received 10 December 1997, Accepted 25 February 1998, Available online 2 May 2002. This work was initiated in the laboratory of D.J.A. and completed at RIKEN. We thank Dr. Qiufu Ma for providing neurogenins' probes. T.S. is a Special Researcher of the Basic Science Program at RIKEN. D.J.A. is an Investigator of the Howard Hughes Medical Institute.

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