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Published March 1, 1959 | public
Journal Article Open

The Reaction of Glutathione with Amino Acids and Related Compounds as Catalyzed by γ-Glutamyl Transpeptidase


In a previous publication (1) methods were described which permit the quantitative estimation of the action of γ-glutamyl transpeptidase upon glutathione. In the present report these methods are employed to study the influence of amino acids. peptides, and other compounds upon the reaction. In addition, we present the results of attempts to account for all the main products formed in the reaction in both the presence and absence of the amino acid, arginine. Data on the distribution of γ-glutamyl transpeptidase activity in a variety of organs and animal species are also given.

Additional Information

Copyright © 1959 by the American Society for Biochemistry and Molecular Biology. (Received for publication, October 10, 1958) This work was supported in part by funds received from the Eugene Higgins Trust through Harvard University. It appears in more detail in the thesis submitted by J.P. Revel, June 1957, to Harvard University in partial fulfillment of the requirements for the degree of Doctor of Philosophy. [J.P.R. was a] Predoctoral Fellow of the Helen Hay Whitney Foundation, 1956-1957.


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