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Published November 15, 2012 | Published
Journal Article Open

In vivo optical-resolution photoacoustic computed tomography with compressed sensing


Optical-resolution photoacoustic microscopy is becoming a powerful research tool for studying microcirculation in vivo. Moreover, ultrasonic-array-based optical-resolution photoacoustic computed tomography (OR-PACT), providing comparable resolution at an improved speed, has opened up new opportunities for studying microvascular dynamics. In this Letter, we have developed a compressed sensing with partially known support (CS-PKS) photoacoustic reconstruction strategy for OR-PACT. Compared with conventional backprojection reconstruction, the CS-PKS strategy was shown to produce high-quality in vivo OR-PACT images with threefold less measurement data, which can be leveraged to improve the data acquisition speed and costs of OR-PACT systems.

Additional Information

© 2012 Optical Society of America. Received September 11, 2012; accepted October 1, 2012; posted October 4, 2012 (Doc. ID 176019); published November 6, 2012. This work was supported in part by the National Natural Science Foundation of China grant no 61205203, the Guangdong Innovation Research Team Fund for Low-Cost Healthcare Technologies (GIRTFLCHT), and the Shenzhen Development and Reform Commission grant no. [2012] 1065.

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