Graphical and stereolithographic models of the developing human heart lumen
Scaled physical models can be useful in analyzing stage-specific hemodynamics in the embryonic human heart to address correlations between early physical stressors and myocardial wall responses. We generated models of the cardiac blood space from reconstructions of four digitized human embryo images from Carnegie Collection at the Armed Forces Institute of Pathology. From physical scale models manufactured by stereolithography, compliant sleeves can be created for flow dynamics studies. This novel use of Carnegie collection images and graphical modeling software provides tools for broadening our understanding of normal and aberrant heart formation.
© 2001 Elsevier Science Ltd. Received 18 July 2000; accepted 19 April 2001. This project was funded by a grant from The Children's Heart Foundation, Chicago.