Catheter-based photoacoustic endoscope for use in the instrument channel of a clinical video endoscope
We have successfully developed a fully-sheathed, flexible shaft-based, mechanical scanning photoacoustic endoscopy (PAE) system for imaging the human gastrointestinal tract via the instrument channel of a clinical video endoscope. The endoscopic system uses a single element ultrasonic transducer and flexible shaft-based proximal actuation mechanism, and it has a 2.5 m long and 3.2 mm diameter catheter section, which can be accommodated in the 3.7 mm diameter instrument channel of a clinical video endoscope. Here, we demonstrate the intra-instrument channel workability and in vivo imaging capability of the PAE system.
© 2015 Society of Photo-Optical Instrumentation Engineers. We thank Prof. James Ballard for his attentive reading of the manuscript, and Dr. Konstantin Maslov for useful discussions on the system design. We also thank Lisa Andrews-Kaminsky and Jenny Kalishman for helping with the animal experiment. This work was sponsored in part by National Institutes of Health grants R01 CA157277, DP1 EB016986 (NIH Director's Pioneer Award), R01 EB016963, and R01 CA159959. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Published - 93230Y.pdf