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Published September 2011 | Accepted Version
Journal Article Open

Gold nanocages as contrast agents for photoacoustic imaging


Gold nanoparticles with tunable absorption and scattering properties have been developed as contrast agents for various optical imaging techniques. As a hybrid modality that combines the merits of both optical and ultrasonic imaging, photoacoustic (PA) imaging also benefits from the use of these nanoparticles to greatly enhance the contrast for visualization of structures and biomarkers in biological tissues. Gold nanocages characterized by hollow interiors, ultrathin and porous walls are of particular interest for in vivo PA imaging because of their compact sizes, bio‐inertness and well‐defined surface chemistry, as well as their strong and highly wavelength‐tunable optical absorption in the near‐infrared (NIR) optical window of soft tissues. This review discusses the application of gold nanocages as a new class of contrast agents for PA imaging in the context of cancer diagnosis.

Additional Information

© 2011 John Wiley & Sons, Ltd. Received: 14 December 2010, Accepted: 15 January 2011. Version of Record online: 25 October 2011. This article is published in Contrast Media and Molecular Imaging as part of the special issue on Photoacoustic Imaging, edited by Dr. Gregory Lanza, Department of Medicine, Washington University Medical Hospital. This work was supported in part by a research grant (1R01 CA138527) from the NCI, an NIH Director's Pioneer Award (DP OD000798) and startup funds from Washington University in St Louis. This work was performed in part at the Nano Research Facility, a member of the National Nanotechnology Infrastructure Network, which is supported by the National Science Foundation (NSF) under ECS‐0335765.

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Accepted Version - nihms-1063551.pdf


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