Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published May 7, 2014 | public
Journal Article Open

A wave dynamics criterion for optimization of mammalian cardiovascular system


The cardiovascular system in mammals follows various optimization criteria covering the heart, the vascular network, and the coupling of the two. Through a simple dimensional analysis we arrived at a non-dimensional number (wave condition number) that can predict the optimum wave state in which the left ventricular (LV) pulsatile power (LV workload) is minimized in a mammalian cardiovascular system. This number is also universal among all mammals independent of animal size maintaining a value of around 0.1. By utilizing a unique in vitro model of human aorta, we tested our hypothesis against a wide range of aortic compliance (pulse wave velocity). We concluded that the optimum value of the wave condition number remains to be around 0.1 for a wide range of aorta compliance that we could simulate in our in-vitro system.

Additional Information

© 2014 Elsevier Ltd. Accepted 13 February 2014. Niema M. Pahlevan acknowledges support from the American Heart Association (AHA) Predoctoral fellowship (Award Id: 12PRE9610015)

Attached Files

Supplemental Material - mmc1.doc

Supplemental Material - mmc2.doc

Supplemental Material - mmc3.doc

Supplemental Material - mmc4.doc

Supplemental Material - mmc5.doc


Files (3.3 MB)
Name Size Download all
1.3 MB Download
33.3 kB Download
1.3 MB Download
705.1 kB Download
33.3 kB Download

Additional details

August 22, 2023
August 22, 2023