Optical and mechanical properties in photorefractive crystal based ultrasound-modulated optical tomography
Ultrasound-modulated optical tomography (UOT) is a new technique that combines laser light and ultrasound to provide images with good optical contrast and good ultrasound resolution in soft biological tissue. We improve the method proposed by Murray et al to obtain UOT images in thick biological tissues with the use of photorefractive crystal based interferometers. It is found that a long ultrasound burst (on the order of a millisecond) can improve the signal-to-noise ratio dramatically. Also with a long ultrasound burst, the response of the acoustic radiation force impulses can be clearly observed in the UOT signal, which will help to acquire images that record both the optical and mechanical properties of biological soft tissues.
Additional Information© 2006 Society of Photo-optical Instrumentation Engineers (SPIE). We thank Chul Hong Kim for assistance with experiments measurements. We also appreciate Sava Sakadžić and Roger Zemp for fruitful scientific discussions. This research was supported by the National Institute of Health grant R33 CA094267 and AFOSR FA9550-04-1-0247.
Published - 608616.pdf