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Published June 28, 2006 | public
Book Section - Chapter

Nanoscale Molecular Transport by Synthetic DNA Machines


Biological systems have evolved motor proteins programmed to perform intracellular transport powered by ATP hydrolysis [23, 14]. Striding along a microtubule with a hand-over-hand gait and a step size of ≈8 nm [26], kinesin is capable of taking ≈100 steps per second, typically negotiating ≈100 steps before falling off the microtubule [4]. Replicating these performance characteristics with a synthetic mimic presents a daunting challenge to molecular engineers pursuing programmable active transport as a means to assembling or probing nanoscale systems.

Additional Information

© 2006 Springer-Verlag Berlin Heidelberg. This work was supported by DARPA and the Air Force Research Laboratory, the Ralph M. Parsons Foundation, the Charles Lee Powell Foundation, and the Caltech Center for Biological Circuit Design.

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August 22, 2023
January 14, 2024