Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published April 25, 2005 | Published
Book Section - Chapter Open

Breast cancer imaging by microwave-induced thermoacoustic tomography


We report a preliminary study of breast cancer imaging by microwave-induced thermoacoustic tomography. In this study, we built a prototype of breast cancer imager based on a circular scan mode. A 3-GHz 0.3~0.5-μs microwave is used as the excitation energy source. A 2.25-MHz ultrasound transducer scans the thermoacoustic signals. All the measured data is transferred to a personal computer for imaging based on our proposed back-projection reconstruction algorithms. We quantified the line spread function of the imaging system. It shows the spatial resolution of our experimental system reaches 0.5 mm. After phantom experiments demonstrated the principle of this technique, we moved the imaging system to the University of Texas MD Anderson Cancer Center to image the excised breast cancer specimens. After the surgery performed by the physicians at the Cancer Center, the excised breast specimen was placed in a plastic cylindrical container with a diameter of 10 cm; and it was then imaged by three imaging modalities: radiograph, ultrasound and thermoacoustic imaging. Four excised breast specimens have been tested. The tumor regions have been clearly located. This preliminary study demonstrated the potential of microwave-induced thermoacoustic tomography for applications in breast cancer imaging.

Additional Information

© 2005 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by the U.S. Army Medical Research and Materiel Command Grant No. DAMD17-00-1-0455, the National Institutes of Health Grants No. R01 EB000712 and No. R01 NS46214, and Texas Higher Education Coordinating Board Grant No. ARP 000512-0063-2001.

Attached Files

Published - 45.pdf


Files (231.8 kB)
Name Size Download all
231.8 kB Preview Download

Additional details

August 19, 2023
January 14, 2024