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Published August 25, 2016 | public
Journal Article

Tag Team Ubiquitin Ligases


Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.

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© 2016 Elsevier Inc. R.J.D. is a founder, shareholder, and member of the scientific advisory board of Cleave Biosciences.

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August 20, 2023
October 20, 2023