On the Structure of Native, Denatured, and Coagulated Proteins

In this paper a structural theory of protein denaturation and coagulation is presented. Since denaturation is a fundamental property of a large group of proteins, a theory of denaturation is essentially a general theory of the structure of native and denatured proteins. In its present form our theory is definite and detailed in some respects and vague in others; refinement in regard to the latter could be achieved on the basis of the results of experiments which the theory suggests. The theory (some features of which have been proposed by other investigators) provides a simple structural interpretation not only of the phenomena connected with denaturation and coagulation which are usually discussed (specificity, solubility, etc.) but also of others, such as the availability of groups, the entropy of denaturation, the effect of ultra-violet light, the heat of activation and its dependence on pH, coagulation through dehydration, etc.