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Published September 9, 2015 | Published
Journal Article Open

Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents To Construct C–C Bonds


The stereocontrolled construction of C−C bonds remains one of the foremost challenges in organic synthesis. At the heart of any chemical synthesis of a natural product or designed small molecule is the need to orchestrate a series of chemical reactions to prepare and functionalize a carbon framework. The advent of transition-metal catalysis has provided chemists with a broad range of new tools to forge C−C bonds and has resulted in a paradigm shift in synthetic strategy planning. The impact of these methods was recognized with the awarding of the 2010 Nobel Prize in Chemistry to Richard Heck, Ei-ichi Negishi, and Akira Suzuki for their seminal contributions to the development of Pd-catalyzed cross-coupling.

Additional Information

© 2015 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Received: March 17, 2015; Publication Date (Web): August 13, 2015. We are grateful for financial support from the National Institutes of Health (Grant GM111805-01), Novartis, and Eli Lilly. Fellowship support from Bristol-Myers Squibb (A.H.C.), the American Chemical Society Division of Organic Chemistry, with sponsorship by Amgen (A.H.C.), and the National Science Foundation (A.H.C., Grant No. DGE-1144469) is gratefully acknowledged.

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August 20, 2023
August 20, 2023