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Published May 29, 1992 | public
Journal Article

The N-end rule


The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Since its discovery in 1986, distinct versions of the N-end rule have been shown to operate in all organisms examined, from animals and plants to yeast and bacteria. This review considers intracellular protein degradation with an emphasis on the N-end rule.

Additional Information

© 1992 Cell Press. I am greatly indebted to the past and present members of the laboratory for helpful discussions and advice. I thank B. Bartel, Ft. Baker, J. Dohmen, M. Ellison, D. Finley, M. Hochstrasser, E. Johnson, N. Johnsson, K. Madura, J. McGrath, I. Ota, J. Tobias, and P. Waker for comments on the manuscript and B. Doran for secretarial assistance. Work in the author's laboratory is supported by grants from the National Institutes of Health.

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