Mouse brain imaging using photoacoustic computed tomography
Photoacoustic computed tomography (PACT) provides structural and functional information when used in small animal brain imaging. Acoustic distortion caused by bone structures largely limits the deep brain image quality. In our work, we present ex vivo PACT images of freshly excised mouse brain, intending that can serve as a gold standard for future PACT in vivo studies on small animal brain imaging. Our results show that structures such as the striatum, hippocampus, ventricles, and cerebellum can be clearly di erentiated. An artery feature called the Circle of Willis, located at the bottom of the brain, can also be seen. These results indicate that if acoustic distortion can be accurately accounted for, PACT should be able to image the entire mouse brain with rich structural information.
Additional Information© 2014 Society of Photo-Optical Instrumentation Engineers. This work was supported in part by NIH awards DP1 EB016986, R01 CA186567, R01 EB 016963, R01 CA134539, R01 EB 010049, R01 CA157277 and R01 CA 159959.
Published - 894340.pdf