Two-dimensional tissue imaging by use of parallel detection of ultrasound-modulated laser speckles
Ultrasound-modulated optical tomography in biological tissue was studied. An ultrasonic beam was focused into a biological tissue sample to modulate the laser light passing through the ultrasonic beam inside the tissue. The speckle field formed by the transmitted laser light was detected by a CCD camera with the source-synchronous-illumination lock- in technique. The ultrasound-modulated laser light reflects the local optical and mechanical properties within the ultrasonic beam and can be used for tomographic imaging of the tissue. We implemented frequency-swept modulation to obtain spatial resolution along the ultrasonic axis. 2D images of biological tissue were successfully obtained with both single frequency modulation and frequency-swept modulation. 3D images could be acquired as well in principle.
Additional Information© 2000 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by the National Institutes of Health grants R29 CA68562, R01 CA71980, and R21 CA83760 and by the National Science Foundation grant BES-9734491.
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