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Published February 2022 | public
Journal Article

Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus


Introduction: The hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13–30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus during movement inhibition is not well understood. Here, we perform a Go/No-Go reaching task in ten patients with medically refractory epilepsy to study human hippocampal beta-power changes during movement. Materials and Methods: Ten epilepsy patients (5 female; ages 21–46) were implanted with intracranial depth electrodes for seizure monitoring and localization. Local field potentials were sampled at 2000 Hz during a Go/No-Go movement task. Comparison of beta-band power between Go and No-Go conditions was conducted using Wilcoxon signed-rank hypothesis testing for each patient. Sub-analyses were conducted to assess differences in the anterior vs posterior contacts, ipsilateral vs contralateral contacts, and male vs female beta-power values. Results: Eight out of ten patients showed significant beta-power decreases during the Go movement response (p < 0.05) compared to baseline. Eight out of ten patients also showed significant beta-power increases in the No-Go condition, occurring in the absence of movement. No significant differences were noted between ipsilateral vs contralateral contacts nor in anterior vs posterior hippocampal contacts. Female participants had a higher task success rate than males and had significantly greater beta-power increases in the No-Go condition (p < 0.001). Conclusion: These findings indicate that increases in hippocampal beta power are associated with movement inhibition. To the best of our knowledge, this study is the first to report this phenomenon in the human hippocampus. The beta band may represent a state-change signal involved in motor processing. Future focus on the beta band in understanding human motor and impulse control will be vital.

Additional Information

© 2021 International Neuromodulation Society. Published by Elsevier Inc. Received 17 November 2020, Revised 8 May 2021, Accepted 1 June 2021, Available online 3 February 2022, Version of Record 3 February 2022. This work was supported by the National Center for Advancing Translational Science (NCATS) of the U.S. National Institutes of Health (KL2TR001854), the Tianqiao and Chrissy Chen Brain-Machine Interface Center at Caltech, the Meira and Shaul G. Massry Foundation, and the Taiwan-USC Postdoctoral Fellowship Program. Authorship Statements: Roberto Martin del Campo-Vera, Austin M. Tang, Angad S. Gogia, Spencer Kellis, and Brian Lee designed the study, including literature review and task design. Rinu Sebastian contributed to programming of the task for patient use. Statistics and analysis were performed by Roberto Martin del Campo-Vera with input from Kuang-Hsuan Chen, Spencer Kellis, and Brian Lee. Roberto Martin del Campo-Vera, Austin M. Tang, Kuang-Hsuan Chen, Zachary D. Gilbert, George Nune, Charles Y. Liu, Spencer Kellis, and Brian Lee contributed to intellectual input for the final manuscript. All authors approved the final manuscript. The authors report no conflicts of interest or financial disclosures. The highest level of ethical adherence was maintained with this manuscript.

Additional details

August 22, 2023
October 23, 2023