CaltechAUTHORS
Published February 24, 2023 | Version Submitted
Discussion Paper Open

Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans

Creators

  • 1. ROR icon Max Planck Institute for Human Development
  • 2. ROR icon Max Planck Institute for Human Cognitive and Brain Sciences
  • 3. ROR icon Tilburg University
  • 4. ROR icon McGill University
  • 5. ROR icon Cedars-Sinai Medical Center
  • 6. ROR icon California Institute of Technology

Abstract

During memory formation, the hippocampus is presumed to represent the "content" of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features that comprise each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.

Additional Information

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. We thank Morgan Barense, Ulrich Mayr, and Markus Werkle-Bergner for fruitful discussions on earlier versions of this work. LW, FK, and DDG were partially funded by an Emmy Noether Program grant from the German Research Foundation (to DDG) and by the Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin. UR was partially supported by NIH NINDS U01NS117839. Data and code availability. Analysed data have been published previously and can be downloaded (https://europepmc.org/article/pmc/pmc5810422). Code to reproduce all main results will be made accessible on Github upon publication. The authors have declared no competing interest.

Attached Files

Submitted - 2023.02.23.529684v1.full.pdf

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2023.02.23.529684v1.full.pdf

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Additional details

Identifiers

Eprint ID
120131
Resolver ID
CaltechAUTHORS:20230316-182104000.12

Funding

Deutsche Forschungsgemeinschaft (DFG)
Max Planck Institute for Human Development
NIH
U01NS117839

Dates

Created
2023-03-22
Created from EPrint's datestamp field
Updated
2023-03-22
Created from EPrint's last_modified field