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Published July 1, 2003 | Published
Journal Article Open

Transmission- and side-detection configurations in ultrasound-modulated optical tomography of thick biological tissues


Ultrasound-modulated optical tomography of thick biological tissues was studied based on speckle-contrast detection. Speckle decorrelation was investigated with biological tissue samples of various thicknesses. Images of optically absorbing objects buried in biological tissue samples with thicknesses up to 50 mm were obtained in a transmission-detection configuration. The image contrast was more than 30%, and the spatial resolution was approximately 2 mm. In addition, a side-detection scheme along with two specific configurations were examined, and the advantages were demonstrated. Experimental results implied feasibility of applying the ultrasound-modulation technique to characterize optical properties in inhomogeneous biological tissues.

Additional Information

© 2003 Optical Society of America. Received 31 October 2002; revised manuscript received 11 March 2003. This project was sponsored in part by National Science Foundation grant BES-9734491, Texas Higher Education Coordinating Board grant 000512-0063-2001, and National Institutes of Health grant R01 EB000712.

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August 19, 2023
October 24, 2023