Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published May 2015 | public
Book Section - Chapter

A Wireless EeG Recording System for Small Animal Models of Heart Regeneration


Heart failure afflicts the developed world, causing mortality more than any other diseases. This is due to the fact that humans' heart possesses a very limited capacity to regenerate. Heart attacks or myocardial infarction (MI) could result in an irreversible loss of cardiomyocytes and consequently heart failure. Besides, zebrafish and neonatal mice are well-known for their magical capacity to recover after ventricular amputation, thus becoming precious models for heart regeneration studies. In this work, we report the first wireless electrocardiography (ECG) recording system for small animal models of heart regeneration. The system consists of a microelectrode array (MEA) and electronic components for wireless powering, signal processing and data communication. The MEA is based on a biocompatible and flexible polymer so it could conform to non-planar anatomical surfaces. The power transfer is achieved using inductive coupling between two solenoids and the ECG signals are sent through an optical link. The wireless operation can free the animal, eliminating anesthesia during experiments and thus minimizing unwanted side effects. The first generation of the device was demonstrated successfully with neonatal mice, revealing awake ECG signals with all features, thereby paving the way to physiologically investigate heart regeneration in long-term without disrupting the animals' normal activities.

Additional Information

© 2015 IEEE. The studies were supported by the National Institutes of Health R01HL-083015 (T.K.H. ) and R01HL111437 (T.K.H.).

Additional details

August 20, 2023
October 18, 2023