Progress toward the Total Synthesis of Saudin: Development of a Tandem Stille-Oxa-Electrocyclization Reaction
A diastereoselective tandem Stille-oxa-electrocyclization reaction provides access to the core of the diterpenoid natural product saudin. Additionally, this new reaction sequence was extended to the convergent preparation of related polycyclic pyran systems.
Additional Information© 2005 American Chemical Society. Received 1 April 2005. Published online 13 May 2005. Published in print 1 June 2005. We are grateful to the California Institute of Technology, NSF-PECASE, and NDSEG (graduate fellowship to U.K.T.) for generous financial support and John F. Zepernick for experimental assistance. We thank Mr. Larry M. Henling and Dr. Michael W. Day for X-ray crystallographic expertise.
Supplemental Material - ol050705bsi20050421_081713.pdf