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Published May 20, 1988 | public
Journal Article

Sequence analysis and neuronal expression of fasciclin I in grasshopper and drosophila


The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Drosophila fasciclin I homolog. In both species, fasciclin I appears to be an extrinsic membrane protein with a signal sequence but no transmembrane region; the protein comprises four homologous domains of approximately 150 amino acids each. Antibodies against Drosophila fasciclin I reveal that it is expressed on the surface of a subset of commissural axon pathways in the embryonic central nervous system and on all sensory axon pathways in the peripheral nervous system. This pattern of expression is similar to that in grasshopper.

Additional Information

© 1988 Cell Press. Received February 11, 1988. We thank Zaida Traquina for excellent technical assistance, Tom Elkins for help with histochemistry, he and Todd Laverty for doing the polytene chromosome in situ work, Ken Burtis for his codon bias program, Allen Harrelson and Michael Bastiani for the grasshopper embryo photographs (Figures 8A and 8C), Russell Doolittle for help with the structural analysis, and Pamela Bjorkman, Nipam Patel, and Peter Snow for helpful discussions. This work was supported by a Helen Hay Whitney Postdoctoral Fellowship (K. Z.), a National Institute of Health (NIH) MSTP Traineeship (L. M.), and grants from the NIH, McKnight Foundation, and March-of-Dimes Birth Defects Foundation (C. S. G.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

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