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Number of items: 325.

2019

Watkins, Ella J. and Almhjell, Patrick J. and Arnold, Frances H. (2019) Direct enzymatic synthesis of a deep-blue fluorescent noncanonical amino acid from azulene and serine. ChemBioChem . ISSN 1439-4227. (In Press) http://resolver.caltech.edu/CaltechAUTHORS:20190912-124018949

Brandenberg, Oliver F. and Miller, David C. and Markel, Ulrich et al. (2019) Engineering Chemoselectivity in Hemoprotein-Catalyzed Indole Amidation. ACS Catalysis, 9 (9). pp. 8271-8275. ISSN 2155-5435. http://resolver.caltech.edu/CaltechAUTHORS:20190807-153750847

Romney, David K. and Sarai, Nicholas S. and Arnold, Frances H. (2019) Nitroalkanes as Versatile Nucleophiles for Enzymatic Synthesis of Noncanonical Amino Acids. ACS Catalysis, 9 (9). pp. 8726-8730. ISSN 2155-5435. http://resolver.caltech.edu/CaltechAUTHORS:20190903-130240854

Arnold, Frances H. (2019) Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture). Angewandte Chemie International Edition . ISSN 1433-7851. (In Press) http://resolver.caltech.edu/CaltechAUTHORS:20190821-144026374

Yang, Kevin K. and Wu, Zachary and Arnold, Frances H. (2019) Machine-learning-guided directed evolution for protein engineering. Nature Methods, 16 (8). pp. 687-694. ISSN 1548-7091. http://resolver.caltech.edu/CaltechAUTHORS:20190715-092459913

Zhang, Juner and Huang, Xiongyi and Zhang, Ruijie K. et al. (2019) Enantiodivergent α-Amino C–H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s. Journal of the American Chemical Society, 141 (25). pp. 9798-9802. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20190607-130827085

Brandenberg, Oliver F. and Chen, Kai and Arnold, Frances H. (2019) Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds. Journal of the American Chemical Society, 141 (22). pp. 8989-8995. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20190509-152409265

Cho, Inha and Jia, Zhi-Jun and Arnold, Frances H. (2019) Site-selective enzymatic C‒H amidation for synthesis of diverse lactams. Science, 364 (6440). pp. 575-578. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20190509-153734557

Wu, Zachary and Kan, S. B. Jennifer and Lewis, Russell D. et al. (2019) Machine learning-assisted directed protein evolution with combinatorial libraries. Proceedings of the National Academy of Sciences of the United States of America, 116 (18). pp. 8852-8858. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:20190415-082330973

Arnold, Frances Hamilton (2019) Advances in directed protein evolution. In: 257th ACS National Meeting & Exposition, 31 March-4 April 2019, Orlando, FL. http://resolver.caltech.edu/CaltechAUTHORS:20190830-082835418

Arnold, Frances Hamilton (2019) Newest advances in enzymatic carbene- and nitrene-transfer catalysis. In: 257th ACS National Meeting & Exposition, 31 March-4 April 2019, Orlando, FL. http://resolver.caltech.edu/CaltechAUTHORS:20190823-075522116

Zhang, Ruijie K. and Huang, Xiongyi and Arnold, Frances H. (2019) Selective C_H bond functionalization with engineered heme proteins: new tools to generate complexity. Current Opinion in Chemical Biology, 49 . pp. 67-75. ISSN 1367-5931. PMCID PMC6461521. http://resolver.caltech.edu/CaltechAUTHORS:20181029-094838266

Cho, Inha and Prier, Christopher K. and Jia, Zhi-Jun et al. (2019) Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein. Angewandte Chemie International Edition, 58 (10). pp. 3138-3142. ISSN 1433-7851. http://resolver.caltech.edu/CaltechAUTHORS:20190102-135256908

Bedbrook, Claire N. and Yang, Kevin K. and Robinson, J. Elliott et al. (2019) Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics. . (Unpublished) http://resolver.caltech.edu/CaltechAUTHORS:20190304-085432637

Chen, Kai and Huang, Xiongyi and Zhang, Shuo-Qing et al. (2019) Engineered Cytochrome c-Catalyzed Lactone-Carbene B–H Insertion. Synlett, 30 (4). pp. 378-382. ISSN 0936-5214. PMCID PMC6436545. http://resolver.caltech.edu/CaltechAUTHORS:20190122-134051110

Huang, Xiongyi and Garcia-Borràs, Marc and Miao, Kun et al. (2019) A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons. ACS Central Science, 5 (2). pp. 270-276. ISSN 2374-7943. PMCID PMC6396380. http://resolver.caltech.edu/CaltechAUTHORS:20181023-102546587

Cho, Inha and Jia, Zhi-Jun and Arnold, Frances H. (2019) Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis. . (Unpublished) http://resolver.caltech.edu/CaltechAUTHORS:20190312-131401661

Zhang, Ruijie K. and Chen, Kai and Huang, Xiongyi et al. (2019) Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp^3 C–H functionalization. Nature, 565 (7737). pp. 67-72. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20181025-100754288

Arnold, Frances H. and Strickland, Donna H. (2019) Nobel Prizes 2018. Deutsche Lebensmittel-Rundschau, 115 (1). pp. 40-41. ISSN 0012-0413. http://resolver.caltech.edu/CaltechAUTHORS:20190213-135152848

2018

Almhjell, Patrick J. and Boville, Christina E. and Arnold, Frances H. (2018) Engineering enzymes for noncanonical amino acid synthesis. Chemical Society Reviews, 47 (24). pp. 8980-8997. ISSN 0306-0012. http://resolver.caltech.edu/CaltechAUTHORS:20181008-141850453

Chen, Kai and Zhang, Shuo-Qing and Brandenberg, Oliver F. et al. (2018) Alternate heme ligation steers activity and selectivity in engineered cytochrome P450-catalyzed carbene transfer reactions. Journal of the American Chemical Society, 140 (48). pp. 16402-16407. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20181030-105013022

Boville, Christina E. and Scheele, Remkes A. and Koch, Philipp et al. (2018) Engineered biosynthesis of β‐alkyl tryptophan analogs. Angewandte Chemie International Edition, 57 (45). pp. 14764-14768. ISSN 1433-7851. http://resolver.caltech.edu/CaltechAUTHORS:20180723-111237018

Yang, Kevin K. and Wu, Zachary and Bedbrook, Claire N. et al. (2018) Learned Protein Embeddings for Machine Learning. Bioinformatics, 34 (15). pp. 2642-2648. ISSN 1367-4803. http://resolver.caltech.edu/CaltechAUTHORS:20180330-110704718

Romney, David K. and Arnold, Frances H. and Lipshutz, Bruce H. et al. (2018) Chemistry Takes a Bath: Reactions in Aqueous Media. Journal of Organic Chemistry, 83 (14). pp. 7319-7322. ISSN 0022-3263. http://resolver.caltech.edu/CaltechAUTHORS:20180723-085717756

Boville, Christina E. and Romney, David K. and Almhjell, Patrick J. et al. (2018) Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima. Journal of Organic Chemistry, 83 (14). pp. 7447-7452. ISSN 0022-3263. PMCID PMC6054569. http://resolver.caltech.edu/CaltechAUTHORS:20180808-152215835

Boville, Christina E. and Romney, David K. and Almhjell, Patrick J. et al. (2018) Improved synthesis of 4-cyanotryptophan and other tryptophan analogs in aqueous solvent using variants of TrpB from Thermotoga maritima. Journal of Organic Chemistry, 83 (14). pp. 7447-7452. ISSN 0022-3263. http://resolver.caltech.edu/CaltechAUTHORS:20180413-091558960

Lewis, Russell D. and Garcia-Borràs, Marc and Chalkley, Matthew J. et al. (2018) Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase. Proceedings of the National Academy of Sciences of the United States of America, 115 (28). pp. 7308-7313. ISSN 0027-8424. PMCID PMC6048479. http://resolver.caltech.edu/CaltechAUTHORS:20180626-131945645

Buller, Andrew R. and van Roye, Paul and Cahn, Jackson K. B. et al. (2018) Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble. Journal of the American Chemical Society, 140 (23). pp. 7256-7266. ISSN 0002-7863. PMCID PMC5999571. http://resolver.caltech.edu/CaltechAUTHORS:20180501-112938311

Arnold, Frances H. (2018) Directed Evolution: Bringing New Chemistry to Life. Angewandte Chemie International Edition, 57 (16). pp. 4143-4148. ISSN 1433-7851. PMCID PMC5901037. http://resolver.caltech.edu/CaltechAUTHORS:20171024-105338006

Chen, Kai and Huang, Xiongyi and Kan, S. B. Jennifer et al. (2018) Enzymatic construction of highly strained carbocycles. Science, 360 (6384). pp. 71-75. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20180405-130352978

Brandenberg, Oliver F. and Prier, Christopher K. and Chen, Kai et al. (2018) Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes. ACS Catalysis, 8 (4). pp. 2629-2634. ISSN 2155-5435. http://resolver.caltech.edu/CaltechAUTHORS:20180312-085606768

Knight, Anders M. and Kan, S. B. Jennifer and Lewis, Russell D. et al. (2018) Diverse engineered heme proteins enable stereodivergent cyclopropanation of unactivated alkenes. ACS Central Science, 4 (3). pp. 372-377. ISSN 2374-7943. PMCID PMC5879470. http://resolver.caltech.edu/CaltechAUTHORS:20171220-092532762

Zhang, Ruijie K. and Romney, David K. and Kan, S. B. Jennifer et al. (2018) Directed Evolution of Artificial Metalloenzymes: Bridging Synthetic Chemistry and Biology. In: Artificial Metalloenzymes and MetalloDNAzymes in Catalysis. Wiley , Hoboken, NJ, pp. 137-170. ISBN 9783527341788. http://resolver.caltech.edu/CaltechAUTHORS:20180502-090421380

2017

Kan, S. B. Jennifer and Huang, Xiongyi and Gumulya, Yosephine et al. (2017) Genetically programmed chiral organoborane synthesis. Nature, 552 (7683). pp. 132-136. ISSN 0028-0836. PMCID PMC5819735. http://resolver.caltech.edu/CaltechAUTHORS:20171027-110146134

Cahn, Jackson K. B. and Brinkmann-Chen, Sabine and Arnold, Frances H. (2017) Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated Structural Analysis and Library Design. In: Synthetic Metabolic Pathways. Methods in Molecular Biology. No.1671. Humana Press , New York, NY, pp. 15-26. ISBN 978-1-4939-7294-4. http://resolver.caltech.edu/CaltechAUTHORS:20171127-143418550

Bedbrook, Claire N. and Yang, Kevin K. and Rice, Austin J. et al. (2017) Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization. PLOS Computational Biology, 13 (10). Art. No. e1005786. ISSN 1553-7358. PMCID PMC5695628. http://resolver.caltech.edu/CaltechAUTHORS:20171030-140148566

Hammer, Stephan C. and Kubik, Grzegorz and Watkins, Ella et al. (2017) Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis. Science, 358 (6360). pp. 215-218. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20171012-132542523

Hammer, Stephan C. and Knight, Anders M. and Arnold, Frances H. (2017) Design and Evolution of Enzymes for Non-natural Chemistry. Current Opinion in Green and Sustainable Chemistry, 7 . pp. 23-30. ISSN 2452-2236. http://resolver.caltech.edu/CaltechAUTHORS:20170628-110616752

Brandenberg, Oliver F. and Fasan, Rudi and Arnold, Frances H. (2017) Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions. Current Opinion in Biotechnology, 47 . pp. 102-111. ISSN 0958-1669 . PMCID PMC5617781. http://resolver.caltech.edu/CaltechAUTHORS:20170713-135322808

Romney, David K. and Murciano-Calles, Javier and Wehrmüller, Jöri E. et al. (2017) Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues. Journal of the American Chemical Society, 139 (31). pp. 10769-10776. ISSN 0002-7863. PMCID PMC5589443. http://resolver.caltech.edu/CaltechAUTHORS:20180820-085301341

Romney, David K. and Murciano-Calles, Javier and Wehrmüller, Jöri Elias et al. (2017) Unlocking reactivity of TrpB: a general biocatalytic platform for synthesis of tryptophan analogs. Journal of the American Chemical Society, 131 (39). pp. 10769-10776. ISSN 0002-7863. PMCID PMC5589443. http://resolver.caltech.edu/CaltechAUTHORS:20170717-101626008

Loskot, Steven A. and Romney, David K. and Arnold, Frances H. et al. (2017) Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme. Journal of the American Chemical Society, 139 (30). pp. 10196-10199. ISSN 0002-7863. PMCID PMC5679227. http://resolver.caltech.edu/CaltechAUTHORS:20170720-100846797

Prier, Christopher K. and Zhang, Ruijie K. and Buller, Andrew R. et al. (2017) Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme. Nature Chemistry, 9 (7). pp. 629-634. ISSN 1755-4330. PMCID PMC5555633. http://resolver.caltech.edu/CaltechAUTHORS:20170413-120718900

Romney, David K. and Murciano-Calles, Javier and Wehrmueller, Joeri et al. (2017) Engineered TrpB biocatalysts for the synthesis of tryptophan analogs. In: 21st Annual Green Chemistry & Engineering Conference, June 13-15, 2015, Reston, VA. http://resolver.caltech.edu/CaltechAUTHORS:20170613-083637399

Arnold, Frances H. (2017) New enzymes for green chemistry. In: 253rd American Chemical Society National Meeting & Exposition, April 2-6, 2017, San Francisco, CA. http://resolver.caltech.edu/CaltechAUTHORS:20170503-092846114

Bedbrook, Claire N. and Rice, Austin J. and Yang, Kevin K. et al. (2017) Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins. Proceedings of the National Academy of Sciences of the United States of America, 114 (13). E2624-E2633. ISSN 0027-8424. PMCID PMC5380088. http://resolver.caltech.edu/CaltechAUTHORS:20170310-130542741

Herwig, Lukas and Rice, Austin J. and Bedbrook, Claire N. et al. (2017) Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore. Cell Chemical Biology, 24 (3). pp. 415-425. ISSN 2451-9456. PMCID PMC5357175. http://resolver.caltech.edu/CaltechAUTHORS:20170307-082231020

Cahn, Jackson K. B. and Werlang, Caroline A. and Baumschlager, Armin et al. (2017) A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases. ACS Synthetic Biology, 6 (2). pp. 326-333. ISSN 2161-5063. http://resolver.caltech.edu/CaltechAUTHORS:20161012-112258970

Murciano-Calles, Javier and Buller, Andrew R. and Arnold, Frances H. (2017) Directed Evolution of an Allosteric Tryptophan Synthase to Create a Platform for Synthesis of Noncanonical Amino Acids. In: Directed Enzyme Evolution: Advances and Applications. Springer , Cham, Switzerland, pp. 1-16. ISBN 978-3-319-50411-7. http://resolver.caltech.edu/CaltechAUTHORS:20180702-074326733

2016

Buller, Andrew R. and van Roye, Paul and Murciano-Calles, Javier et al. (2016) Tryptophan synthase uses an atypical mechanism to achieve substrate specificity. Biochemistry, 55 (51). pp. 7043-7046. ISSN 0006-2960. PMCID PMC5207025. http://resolver.caltech.edu/CaltechAUTHORS:20161212-095113284

Kan, S. B. Jennifer and Lewis, Russell D. and Chen, Kai et al. (2016) Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life. Science, 354 (6315). pp. 1048-1051. ISSN 0036-8075. PMCID PMC5243118. http://resolver.caltech.edu/CaltechAUTHORS:20161004-120856195

Hernandez, Kari E. and Renata, Hans and Lewis, Russell D. et al. (2016) Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor. ACS Catalysis, 6 (11). pp. 7810-7813. ISSN 2155-5435. PMCID PMC5340201. http://resolver.caltech.edu/CaltechAUTHORS:20161024-123654794

Renata, Hans and Lewis, Russell D. and Sweredoski, Michael J. et al. (2016) Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes. Journal of the American Chemical Society, 138 (38). pp. 12527-12533. ISSN 0002-7863. PMCID PMC5042878. http://resolver.caltech.edu/CaltechAUTHORS:20160919-123244987

Murciano-Calles, Javier and Romney, David K. and Brinkmann-Chen, Sabine et al. (2016) A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation. Angewandte Chemie International Edition, 55 (38). pp. 11577-11581. ISSN 1433-7851. PMCID PMC5014574. http://resolver.caltech.edu/CaltechAUTHORS:20160812-092420412

Moraïs, Sarah and Stern, Johanna and Kahn, Amaranta et al. (2016) Enhancement of cellulosome-mediated deconstruction of cellulose by improving enzyme thermostability. Biotechnology for Biofuels, 9 . Art. No. 164. ISSN 1754-6834. PMCID PMC4973527. http://resolver.caltech.edu/CaltechAUTHORS:20160816-065945854

Herger, Michael and van Roye, Paul and Romney, David K. et al. (2016) Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase. Journal of the American Chemical Society, 138 (27). pp. 8388-8391. ISSN 0002-7863. PMCID PMC4948191. http://resolver.caltech.edu/CaltechAUTHORS:20160706-081124141

Cahn, Jackson K. B. and Brinkmann-Chen, Sabine and Buller, Andrew R. et al. (2016) Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases. Protein Science, 25 (7). pp. 1241-1248. ISSN 0961-8368. PMCID PMC4918412. http://resolver.caltech.edu/CaltechAUTHORS:20151215-081458127

Dodani, Sheel C. and Kiss, Gert and Cahn, Jackson K. B. et al. (2016) Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models. Nature Chemistry, 8 (5). pp. 419-425. ISSN 1755-4330. PMCID PMC4843824. http://resolver.caltech.edu/CaltechAUTHORS:20160323-124510465

Prier, Christopher K. and Hyster, Todd K. and Farwell, Christopher C. et al. (2016) Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy. Angewandte Chemie International Edition, 55 (15). pp. 4711-4715. ISSN 1433-7851. PMCID PMC4818679. http://resolver.caltech.edu/CaltechAUTHORS:20160317-072334231

Chang, Chia-Jung and Lee, Cheng-Chung and Chan, Yueh-Te et al. (2016) Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination. PLoS ONE, 11 (3). Art. No. e0147485. ISSN 1932-6203. PMCID PMC4795783. http://resolver.caltech.edu/CaltechAUTHORS:20160328-142111017

Rice, Austin J. and Bedbrook, Claire N. and Yang, Kevin K. et al. (2016) Rhodopsin Engineering through Structure-Guided Recombination. Biophysical Journal, 110 (3). 170A. ISSN 0006-3495. http://resolver.caltech.edu/CaltechAUTHORS:20160603-153016574

Cahn, J. K. B. and Baumschlager, A. and Brinkmann-Chen, S. et al. (2016) Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes. Protein Engineering Design and Selection, 29 (1). pp. 31-38. ISSN 1741-0126. PMCID PMC4678007. http://resolver.caltech.edu/CaltechAUTHORS:20151030-152836183

2015

Buller, Andrew R. and Brinkmann-Chen, Sabine and Romney, David K. et al. (2015) Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation. Proceedings of the National Academy of Sciences of the United States of America, 112 (47). pp. 14599-14604. ISSN 0027-8424. PMCID PMC4664345. http://resolver.caltech.edu/CaltechAUTHORS:20151112-080107171

Prier, Christopher K. and Arnold, Frances H. (2015) Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts. Journal of the American Chemical Society, 137 (44). pp. 13992-14006. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20151105-083025660

McIntosh, John A. and Heel, Thomas and Buller, Andrew R. et al. (2015) Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450. Journal of the American Chemical Society, 137 (43). pp. 13861-13865. ISSN 0002-7863. PMCID PMC4635421. http://resolver.caltech.edu/CaltechAUTHORS:20150928-085007684

Arnold, Frances H. (2015) The nature of chemical innovation: new enzymes by evolution. Quarterly Reviews of Biophysics, 48 (4). pp. 404-410. ISSN 0033-5835. http://resolver.caltech.edu/CaltechAUTHORS:20151109-085022815

Bedbrook, Claire N. and Kato, Mihoko and Ravindra Kumar, Sripriya et al. (2015) Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. Chemistry and Biology, 22 (8). pp. 1108-1121. ISSN 1074-5521. PMCID PMC4546540. http://resolver.caltech.edu/CaltechAUTHORS:20150728-090618874

McIsaac, R. Scott and Bedbrook, Claire N. and Arnold, Frances H. (2015) Recent advances in engineering microbial rhodopsins for optogenetics. Current Opinion in Structural Biology, 33 . pp. 8-15. ISSN 0959-440X. PMCID PMC4641784. http://resolver.caltech.edu/CaltechAUTHORS:20150612-152121122

Cahn, Jackson K. B. and Brinkmann-Chen, Sabine and Spatzal, Thomas et al. (2015) Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases. Biochemical Journal, 468 (3). pp. 475-484. ISSN 0264-6021. PMCID PMC4550535. http://resolver.caltech.edu/CaltechAUTHORS:20151001-082128409

Farwell, Christopher C. and Zhang, Ruijie K. and McIntosh, John A. et al. (2015) Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450. ACS Central Science, 1 (2). pp. 89-93. ISSN 2374-7951. PMCID PMC4571169. http://resolver.caltech.edu/CaltechAUTHORS:20150504-091714076

Renata, Hans and Wang, Z. Jane and Arnold, Frances H. (2015) Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution. Angewandte Chemie International Edition, 54 (11). pp. 3351-3367. ISSN 1433-7851. PMCID PMC4404643. http://resolver.caltech.edu/CaltechAUTHORS:20150209-090308645

Engqvist, Martin K. M. and McIsaac, R. Scott and Dollinger, Peter et al. (2015) Directed Evolution of Gloeobacter violaceus Rhodopsin Spectral Properties. Journal of Molecular Biology, 427 (1). pp. 205-220. ISSN 0022-2836. http://resolver.caltech.edu/CaltechAUTHORS:20140707-083154824

Hyster, Todd K. and Arnold, Frances H. (2015) P450_(BM3)-Axial Mutations: A Gateway to Non-Natural Reactivity. Israel Journal of Chemistry, 55 (1). pp. 14-20. ISSN 0021-2148. http://resolver.caltech.edu/CaltechAUTHORS:20140825-135432162

2014

Trudeau, Devin L. and Lee, Toni M. and Arnold, Frances H. (2014) Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose hydrolysis at elevated temperatures. Biotechnology and Bioengineering, 111 (12). pp. 2390-2397. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20140618-110555181

Heel, Thomas and McIntosh, John A. and Dodani, Sheel C. et al. (2014) Non-natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins. ChemBioChem, 15 (17). pp. 2556-2562. ISSN 1439-4227. PMCID PMC4287214. http://resolver.caltech.edu/CaltechAUTHORS:20141015-151531581

Hyster, Todd K. and Farwell, Christopher C. and Buller, Andrew R. et al. (2014) Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C−H Amination. Journal of the American Chemical Society, 136 (44). pp. 15505-15508. ISSN 0002-7863. PMCID PMC4227740. http://resolver.caltech.edu/CaltechAUTHORS:20141027-111433880

Brinkmann-Chen, S. and Cahn, J. K. B. and Arnold, Frances H. (2014) Uncovering rare NADH-preferring ketol-acid reductoisomerases. Metabolic Engineering, 26 . pp. 17-22. ISSN 1096-7176. http://resolver.caltech.edu/CaltechAUTHORS:20140902-115405020

Dodani, Sheel C. and Cahn, Jackson K. B. and Heinisch, Tillmann et al. (2014) Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE. ChemBioChem, 15 (15). pp. 2259-2267. ISSN 1439-4227. PMCID PMC4260628. http://resolver.caltech.edu/CaltechAUTHORS:20140908-101026220

Renata, Hans and Wang, Z. Jane and Kitto, Rebekah Z. et al. (2014) P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions. Catalysis Science and Technology, 4 (10). pp. 3640-3643. ISSN 2044-4753. PMCID PMC4159215. http://resolver.caltech.edu/CaltechAUTHORS:20140714-152320951

Flytzanis, Nicholas C. and Bedbrook, Claire N. and Chiu, Hui et al. (2014) Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons. Nature Communications, 5 (9). Art. No. 4894. ISSN 2041-1723. PMCID PMC4166526. http://resolver.caltech.edu/CaltechAUTHORS:20140730-113211664

McIsaac, R. Scott and Engqvist, Martin K. M. and Wannier, Timothy et al. (2014) Directed evolution of a far-red fluorescent rhodopsin. Proceedings of the National Academy of Sciences of the United States of America, 111 (36). pp. 13034-13039. ISSN 0027-8424. PMCID PMC4246972. http://resolver.caltech.edu/CaltechAUTHORS:20140825-213535516

Sun, Fei and Zhang, Wen-Bin and Mahdavi, Alborz et al. (2014) Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry. Proceedings of the National Academy of Sciences of the United States of America, 111 (31). pp. 11269-11274. ISSN 0027-8424. PMCID PMC4128157. http://resolver.caltech.edu/CaltechAUTHORS:20140722-093927552

Lin, Paul P. and Rabe, Kersten S. and Takasumi, Jennifer L. et al. (2014) Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius. Metabolic Engineering, 24 . pp. 1-8. ISSN 1096-7176. http://resolver.caltech.edu/CaltechAUTHORS:20140421-110219081

Smith, Matthew A. and Arnold, Frances H. (2014) Designing libraries of chimeric proteins using SCHEMA recombination and RASPP. In: Directed Evolution Library Creation: Methods and Protocols. Methods in Molecular Biology. No.1179. Humana Press , New York, NY, pp. 335-343. ISBN 978-1-4939-1052-6. http://resolver.caltech.edu/CaltechAUTHORS:20131015-081653940

Smith, Matthew A. and Arnold, Frances H. (2014) Noncontiguous SCHEMA Protein Recombination. In: Directed Evolution Library Creation: Methods and Protocols. Methods in Molecular Biology. No.1179. Humana Press , New York, NY, pp. 345-352. ISBN 9781493910526. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726128

Wang, Jane Z. and Renata, Hans and Peck, Nicole E. et al. (2014) Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran. Angewandte Chemie International Edition, 53 (26). pp. 6810-6813. ISSN 1433-7851. PMCID PMC4120663. http://resolver.caltech.edu/CaltechAUTHORS:20140512-091600678

Farwell, Christopher C. and McIntosh, John A. and Hyster, Todd K. et al. (2014) Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer. Journal of the American Chemical Society, 136 (24). pp. 8766-8771. ISSN 0002-7863. PMCID PMC4154708. http://resolver.caltech.edu/CaltechAUTHORS:20140610-140803475

Arnold, Frances H. and Meyerowitz, Joseph T. (2014) Synthetic biology: Engineering explored. Nature, 509 (7499). pp. 166-167. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20140605-090429625

McIntosh, John A. and Farwell, Christopher C. and Arnold, Frances H. (2014) Expanding P450 catalytic reaction space through evolution and engineering. Current Opinion in Chemical Biology, 19 . pp. 126-134. ISSN 1367-5931. PMCID PMC4008644. http://resolver.caltech.edu/CaltechAUTHORS:20140407-153730279

Ener, M. E. and Coelho, P. S. and Wang, Z. J. et al. (2014) Photo-initiated and electron transfer reactivity of ruthenium-labeled cytochrome P450. Journal of Biological Inorganic Chemistry, 19 (S1). S219. ISSN 0949-8257. http://resolver.caltech.edu/CaltechAUTHORS:20140425-092704426

Coelho, P. S. and Arnold, F. H. and Lewis, J. C. (2014) Synthetic Biology Approaches for Organic Synthesis. In: Comprehensive Organic Synthesis II. Elsevier , Amsterdam, pp. 390-420. ISBN 978-0-08-097743-0. http://resolver.caltech.edu/CaltechAUTHORS:20150202-095412727

2013

Smith, Matthew A. and Bedbrook, Claire N. and Wu, Timothy et al. (2013) Hypocrea jecorina Cellobiohydrolase I Stabilizing Mutations Identified Using Noncontiguous Recombination. ACS Synthetic Biology, 2 (12). pp. 690-696. ISSN 2161-5063. http://resolver.caltech.edu/CaltechAUTHORS:20131015-082946657

Trudeau, Devin L. and Smith, Matthew A. and Arnold, Frances H. (2013) Innovation by homologous recombination. Current Opinion in Chemical Biology, 17 (6). pp. 902-909. ISSN 1367-5931. http://resolver.caltech.edu/CaltechAUTHORS:20131030-110816201

Wang, Z. Jane and Peck, Nicole E. and Renata, Hans et al. (2013) Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds. Chemical Science, 5 (2). pp. 598-601. ISSN 2041-6520. PMCID PMC3906682. http://resolver.caltech.edu/CaltechAUTHORS:20140130-083407487

Arnold, Frances H. (2013) Expanding the enzyme universe through a marriage of chemistry and evolution. In: New chemistry and new opportunities from the expanding protein universe. World Scientific , Hackensack, NJ, pp. 84-89. ISBN 978-981-4603-82-9. http://resolver.caltech.edu/CaltechAUTHORS:20150519-132607405

Zhang, Wen-Bin and Sun, Fei and Tirrell, David A. et al. (2013) Controlling Macromolecular Topology with Genetically Encoded SpyTag-SpyCatcher Chemistry. Journal of the American Chemical Society, 135 (37). pp. 13988-13997. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20140221-084933853

Zhang, Wen-Bin and Sun, Fei and Arnold, Frances H. et al. (2013) Cellular synthesis of non-linear proteins. In: 246th ACS National Meeting & Exposition, Sept. 8-12, 2013, Indianapolis, IN. http://resolver.caltech.edu/CaltechAUTHORS:20131010-083215575

McIntosh, John A. and Coelho, Pedro S. and Farwell, Christopher C. et al. (2013) Enantioselective Intramolecular C-H Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo. Angewandte Chemie International Edition, 52 (35). pp. 9309-9312. ISSN 1433-7851. PMCID PMC3988694. http://resolver.caltech.edu/CaltechAUTHORS:20131003-083816907

Wu, Indira and Heel, Thomas and Arnold, Frances H. (2013) Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases. Biochimica et Biophysica Acta - Proteins and Proteomics, 1834 (8). pp. 1539-1544. ISSN 1570-9639 . http://resolver.caltech.edu/CaltechAUTHORS:20130819-153647713

Coelho, Pedro S. and Wang, Z. Jane and Ener, Maraia E. et al. (2013) A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nature Chemical Biology, 9 (8). pp. 485-487. ISSN 1552-4450. PMCID PMC3720782. http://resolver.caltech.edu/CaltechAUTHORS:20130830-095755657

Brinkmann-Chen, Sabine and Flock, Tilman and Cahn, Jackson K. B. et al. (2013) General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH. Proceedings of the National Academy of Sciences of the United States of America, 110 (27). pp. 10946-10951. ISSN 0027-8424. PMCID PMC3704004. http://resolver.caltech.edu/CaltechAUTHORS:20130905-104306564

Wu, Indira and Arnold, Frances H. (2013) Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures. Biotechnology and Bioengineering, 110 (7). pp. 1874-1883. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20130703-095728488

Lauchli, Ryan and Rabe, Kersten S. and Kalbarczyk, Karolina Z. et al. (2013) High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase. Angewandte Chemie International Edition, 52 (21). pp. 5571-5574. ISSN 1433-7851. PMCID PMC3828198. http://resolver.caltech.edu/CaltechAUTHORS:20130701-105908055

Smith, Matthew A. and Romero, Philip A. and Wu, Timothy et al. (2013) Chimeragenesis of distantly-related proteins by noncontiguous recombination. Protein Science, 22 (2). pp. 231-238. ISSN 0961-8368. PMCID PMC3588919. http://resolver.caltech.edu/CaltechAUTHORS:20130226-103727663

Coelho, Pedro S. and Brustad, Eric M. and Kannan, Arvind et al. (2013) Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes. Science, 339 (6117). pp. 307-310. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20130208-132114060

Romero, Philip A. and Krause, Andreas and Arnold, Frances H. (2013) Navigating the protein fitness landscape with Gaussian processes. Proceedings of the National Academy of Sciences of the United States of America, 110 (3). E193-E201. ISSN 0027-8424. PMCID PMC3549130. http://resolver.caltech.edu/CaltechAUTHORS:20130225-163008905

Romero, Philip A. and Shapiro, Mikhail G. and Arnold, Frances H. et al. (2013) Directed Evolution of Protein-Based Neurotransmitter Sensors for MRI. In: Chemical Neurobiology : Methods and Protocols. Methods in Molecular Biology. No.995. Springer , New York, NY, pp. 193-205. ISBN 978-1-62703-344-2. PMCID PMC3818115. http://resolver.caltech.edu/CaltechAUTHORS:20130410-132453635

Heinzelman, Pete and Romero, Philip A. and Arnold, Frances H. (2013) Efficient Sampling of SCHEMA Chimera Families to Identify Useful Sequence Elements. In: Methods in Protein Design. Methods in Enzymology. No.523. Elsevier , Amsterdam, pp. 351-368. ISBN 9780123942920. http://resolver.caltech.edu/CaltechAUTHORS:20130620-125417347

2012

Liu, Xiang and Bastian, Sabine and Snow, Christopher D. et al. (2012) Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol. Journal of Biotechnology, 164 (2). pp. 188-195. ISSN 0168-1656. PMCID PMC3542407. http://resolver.caltech.edu/CaltechAUTHORS:20130611-082534229

Komor, Russell S. and Romero, Philip A. and Xie, Catherine B. et al. (2012) Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods. Protein Engineering, Design and Selection, 25 (12). pp. 827-833. ISSN 1741-0126. http://resolver.caltech.edu/CaltechAUTHORS:20130107-104235257

Smith, Matthew A. and Rentmeister, Andrea and Snow, Christopher D. et al. (2012) A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure-guided recombination. FEBS Journal, 279 (24). pp. 4453-4465. ISSN 1742-464X. http://resolver.caltech.edu/CaltechAUTHORS:20130114-102154716

Romero, Philip A. and Arnold, Frances H. (2012) Random Field Model Reveals Structure of the Protein Recombinational Landscape. PLoS Computational Biology, 8 (10). Art. No. e1002713. ISSN 1553-734X. PMCID PMC3464211. http://resolver.caltech.edu/CaltechAUTHORS:20130220-094932746

Brustad, Eric M. and Lelyveld, Victor S. and Snow, Christopher D. et al. (2012) Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin. Journal of Molecular Biology, 422 (2). pp. 245-262. ISSN 0022-2836. PMCID PMC3418479. http://resolver.caltech.edu/CaltechAUTHORS:20121030-144039360

Lee, Toni and Farrow, Mary and Arnold, Frances et al. (2012) Computational Thermostable Cellulase Engineering for Enhanced Biofuel Production. Protein Science, 21 (S1). pp. 71-72. ISSN 0961-8368. http://resolver.caltech.edu/CaltechAUTHORS:20120824-161422230

Snow, Christopher and Brustad, Eric and Arnold, Frances (2012) High Resolution Models from Low Resolution Data: Recombination of Fragments for Crystallographic Structure Determination. Protein Science, 21 (S1). pp. 91-92. ISSN 0961-8368. http://resolver.caltech.edu/CaltechAUTHORS:20120828-070344527

Lelyveld, Victor and Brustad, Eric and Arnold, Frances et al. (2012) Metalloprotein-based contrast sensors for neurochemical detection by MRI. Protein Science, 21 (S1). p. 184. ISSN 0961-8368. http://resolver.caltech.edu/CaltechAUTHORS:20120827-083652928

Romero, Philip A. and Stone, Everett and Lamb, Candice et al. (2012) SCHEMA-Designed Variants of Human Arginase I and II Reveal Sequence Elements Important to Stability and Catalysis. ACS Synthetic Biology, 1 (6). pp. 221-228. ISSN 2161-5063. PMCID PMC3378063. http://resolver.caltech.edu/CaltechAUTHORS:20120716-102139957

Chen, Mike M. Y. and Snow, Christopher D. and Vizcarra, Christina L. et al. (2012) Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. Protein Engineering, Design and Selection, 25 (4). pp. 171-178. ISSN 1741-0126. http://resolver.caltech.edu/CaltechAUTHORS:20120420-110357141

Chen, Mike M. Y. and Snow, Christopher D. and Vizcarra, Christina L. et al. (2012) Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. Protein Engineering, Design and Selection, 25 (4). pp. 171-178. ISSN 1741-0126. http://resolver.caltech.edu/CaltechAUTHORS:20180821-073419790

Chen, Mike M. Y. and Coelho, Pedro S. and Arnold, Frances H. (2012) Utilizing Terminal Oxidants to Achieve P450-Catalyzed Oxidation of Methane. Advanced Synthesis and Catalysis, 354 (6). pp. 964-968. ISSN 1615-4150. http://resolver.caltech.edu/CaltechAUTHORS:20120522-134624475

Bastian, Sabine and Arnold, Frances H. (2012) Reversal of NAD(P)H Cofactor Dependence by Protein Engineering. In: Microbial Metabolic Engineering. Methods in Molecular Biology. No.834. Springer , New York, pp. 17-31. ISBN 9781617794834. http://resolver.caltech.edu/CaltechAUTHORS:20111216-135337154

2011

Jung, Sang Taek and Lauchli, Ryan and Arnold, Frances H. (2011) Cytochrome P450: taming a wild type enzyme. Current Opinion in Biotechnology, 22 (6). pp. 809-817. ISSN 0958-1669 . PMCID PMC3118264. http://resolver.caltech.edu/CaltechAUTHORS:20120124-113657235

Lee, Toni M. and Farrow, Mary F. and Arnold, Frances H. et al. (2011) A structural study of Hypocrea jecorina Cel5A. Protein Science, 20 (11). pp. 1935-1940. ISSN 0961-8368. PMCID PMC3267957. http://resolver.caltech.edu/CaltechAUTHORS:20111111-135716977

Farrow, Mary F. and Arnold, Frances H. (2011) High Throughput Screening of Fungal Endoglucanase Activity in Escherichia coli. Journal of Visualized Experiments , 54 . Art. No. e2942. ISSN 1940-087X . http://resolver.caltech.edu/CaltechAUTHORS:20180821-075520096

Rentmeister, Andrea and Brown, Tristan R. and Snow, Christopher D. et al. (2011) Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9. ChemCatChem, 3 (6). pp. 1065-1071. ISSN 1867-3880. http://resolver.caltech.edu/CaltechAUTHORS:20111202-122055370

Bastian, Sabine and Liu, Xiang and Meyerowitz, Joseph T. et al. (2011) Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli. Metabolic Engineering, 13 (3). pp. 345-352. ISSN 1096-7176. http://resolver.caltech.edu/CaltechAUTHORS:20110526-140043166

Brustad, Eric M. and Arnold, Frances H. (2011) Optimizing non-natural protein function with directed evolution. Current Opinion in Chemical Biology, 15 (2). pp. 201-210. ISSN 1367-5931. PMCID PMC3080047. http://resolver.caltech.edu/CaltechAUTHORS:20110518-102635009

Fasan, Rudi and Crook, Nathan C. and Peters, Matthew W. et al. (2011) Improved Product-Per-Glucose Yields in P450-Dependent Propane Biotransformations Using Engineered Escherichia coli. Biotechnology and Bioengineering, 108 (3). pp. 500-510. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20110301-113228764

Brenner, Katie and Arnold, Frances H. (2011) Self-Organization, Layered Structure, and Aggregation Enhance Persistence of a Synthetic Biofilm Consortium. PLoS ONE, 6 (2). Art. No. e16791 . ISSN 1932-6203. PMCID PMC3036657. http://resolver.caltech.edu/CaltechAUTHORS:20110307-110900429

Lelyveld, Victor S. and Brustad, Eric and Arnold, Frances H. et al. (2011) Metal-Substituted Protein MRI Contrast Agents Engineered for Enhanced Relaxivity and Ligand Sensitivity. Journal of the American Chemical Society, 133 (4). pp. 649-651. ISSN 0002-7863. PMCID PMC3154012. http://resolver.caltech.edu/CaltechAUTHORS:20110322-095840300

Mingardon, Florence and Bagert, John D. and Maisonnier, Cyprien et al. (2011) Comparison of Family 9 Cellulases from Mesophilic and Thermophilic Bacteria. Applied and Environmental Microbiology, 77 (4). pp. 1436-1442. ISSN 0099-2240. PMCID PMC3067227. http://resolver.caltech.edu/CaltechAUTHORS:20110214-092102779

Lewis, Jared C. and Coelho, Pedro S. and Arnold, Frances H. (2011) Enzymatic functionalization of carbon-hydrogen bonds. Chemical Society Reviews, 40 (4). pp. 2003-2021. ISSN 0306-0012. PMCID PMC3064445. http://resolver.caltech.edu/CaltechAUTHORS:20110414-084904112

2010

Lewis, Jared C. and Mantovani, Simone M. and Fu, Yu et al. (2010) Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450_(BM3) for Selective Hydroxylation of Large Substrates. ChemBioChem, 11 (18). pp. 2502-2505. ISSN 1439-4227. PMCID PMC4447097. http://resolver.caltech.edu/CaltechAUTHORS:20110118-104553247

Farrow, Mary F. and Arnold, Frances H. (2010) Combinatorial Recombination of Gene Fragments to Construct a Library of Chimeras. Current Protocols in Protein Science, 62 (1). 26.2.1-26.2.20. ISSN 1934-3655. http://resolver.caltech.edu/CaltechAUTHORS:20180820-160726572

Heinzelman, Pete and Komor, Russell and Kanaan, Arvind et al. (2010) Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination. Protein Engineering, Design and Selection, 23 (11). pp. 871-880. ISSN 1741-0126. http://resolver.caltech.edu/CaltechAUTHORS:20101108-110520683

Acar, Murat and Pando, Bernardo F. and Arnold, Frances H. et al. (2010) A General Mechanism for Network-Dosage Compensation in Gene Circuits. Science, 329 (5999). pp. 1656-1660. ISSN 0036-8075. PMCID PMC3138731. http://resolver.caltech.edu/CaltechAUTHORS:20101011-132711462

Jäckel, Christian and Bloom, Jesse D. and Kast, Peter et al. (2010) Consensus Protein Design without Phylogenetic Bias. Journal of Molecular Biology, 399 (4). pp. 541-546. ISSN 0022-2836. PMCID PMC2904866. http://resolver.caltech.edu/CaltechAUTHORS:20100713-090942319

Shapiro, Mikhail G. and Westmeyer, Gil G. and Romero, Philip A. et al. (2010) Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Nature Biotechnology, 28 (3). pp. 264-270. ISSN 1087-0156. PMCID PMC3073400. http://resolver.caltech.edu/CaltechAUTHORS:20100326-111303498

2009

Romero, Philip A. and Arnold, Frances H. (2009) Exploring protein fitness landscapes by directed evolution. Nature Reviews. Molecular Cell Biology, 10 (12). pp. 866-876. ISSN 1471-0072. PMCID PMC2997618. http://resolver.caltech.edu/CaltechAUTHORS:20091210-104030533

Sawayama, Andrew M. and Chen, Michael M. Y. and Kulanthaivel, Palaniappan et al. (2009) A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds. Chemistry: a European Journal, 15 (43). pp. 11723-11729. ISSN 0947-6539. PMCID PMC3118466. http://resolver.caltech.edu/CaltechAUTHORS:20091210-103923398

Sawayama, Andrew M. and Chen, Michael M. Y. and Kulanthaivel, Palaniappan et al. (2009) A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds. Chemistry: a European Journal, 15 (43). pp. 11723-11729. ISSN 0947-6539. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144311628

Lewis, Jared C. and Bastian, Sabine and Bennett, Clay S. et al. (2009) Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450_(BM3) demethylases. Proceedings of the National Academy of Sciences of the United States of America, 106 (39). pp. 16550-16555. ISSN 0027-8424. PMCID PMC2757845. http://resolver.caltech.edu/CaltechAUTHORS:20091020-094419644

Heinzelman, Pete and Snow, Christopher D. and Smith, Matthew A. et al. (2009) SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation That Contributes Markedly to Stability. Journal of Biological Chemistry, 284 (39). pp. 26229-26233. ISSN 0021-9258. PMCID PMC2785310. http://resolver.caltech.edu/CaltechAUTHORS:20091013-093450880

Dougherty, Michael J. and Arnold, Frances H. (2009) Directed evolution: new parts and optimized function. Current Opinion in Biotechnology, 20 (4). pp. 486-491. ISSN 0958-1669 . PMCID PMC2775421. http://resolver.caltech.edu/CaltechAUTHORS:20100108-141256886

Bloom, Jesse D. and Arnold, Frances H. (2009) In the light of directed evolution: Pathways of adaptive protein evolution. Proceedings of the National Academy of Sciences of the United States of America, 106 (Supple). pp. 9995-10000. ISSN 0027-8424. PMCID PMC2702793. http://resolver.caltech.edu/CaltechAUTHORS:20090812-201735689

Lewis, Jared C. and Arnold, Frances H. (2009) Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM3. Chimia, 63 (6). pp. 309-312. ISSN 0009-4293. http://resolver.caltech.edu/CaltechAUTHORS:20090914-094240617

Heinzelman, Pete and Snow, Christopher D. and Wu, Indira et al. (2009) A family of thermostable fungal cellulases created by structure-guided recombination. Proceedings of the National Academy of Sciences of the United States of America, 106 (14). pp. 5610-5615. ISSN 0027-8424. PMCID PMC2667002. http://resolver.caltech.edu/CaltechAUTHORS:20090629-142611326

Tracewell, Cara A. and Arnold, Frances H. (2009) Directed enzyme evolution: climbing fitness peaks one amino acid at a time. Current Opinion in Chemical Biology, 13 (1). pp. 3-9. ISSN 1367-5931. PMCID PMC2703427. http://resolver.caltech.edu/CaltechAUTHORS:20090910-084155263

Rentmeister, Andrea and Arnold, Frances H. and Fasan, Rudi (2009) Chemo-enzymatic fluorination of unactivated organic compounds. Nature Chemical Biology, 5 (1). pp. 26-28. ISSN 1552-4450. PMCID PMC2713661. http://resolver.caltech.edu/CaltechAUTHORS:RENncb09

Koch, Daniel J. and Chen, Mike M. and van Beilen, Jan B. et al. (2009) In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6. Applied and Environmental Microbiology, 75 (2). pp. 337-344. ISSN 0099-2240. PMCID PMC2620723. http://resolver.caltech.edu/CaltechAUTHORS:KOCaem09

Brenner, Katie and You, Lingchong and Arnold, Frances H. (2009) Response to Goldman and Brown: Making sense of microbial consortia using ecology and evolution. Trends in Biotechnology, 27 (1). p. 4. ISSN 0167-7799. http://resolver.caltech.edu/CaltechAUTHORS:BREtib09

Arnold, F. H. (2009) How Proteins Adapt: Lessons from Directed Evolution. In: Evolution: the Molecular Landscape. Cold Spring Harbor Symposia on Quantitative Biology . No.74. Cold Spring Harbor Laboratory Press , Woodbury, NY, pp. 41-46. ISBN 978-087969870-6. http://resolver.caltech.edu/CaltechAUTHORS:20120904-095323598

2008

Fasan, Rudi and Meharenna, Yergalem T. and Snow, Christopher D. et al. (2008) Evolutionary History of a Specialized P450 Propane Monooxygenase. Journal of Molecular Biology, 383 (5). pp. 1069-1080. ISSN 0022-2836. PMCID PMC2637765. http://resolver.caltech.edu/CaltechAUTHORS:FASjmb08

Brenner, Katie and You, Lingchong and Arnold, Frances H. (2008) Engineering microbial consortia: a new frontier in synthetic biology. Trends in Biotechnology, 26 (9). pp. 483-489. ISSN 0167-7799. http://resolver.caltech.edu/CaltechAUTHORS:BREtb08

Balagaddé, Frederick K. and Song, Hao and Ozaki, Jun et al. (2008) A synthetic Escherichia coli predator–prey ecosystem. Molecular Systems Biology, 4 . Art. No. 187. ISSN 1744-4292. PMCID PMC2387235. http://resolver.caltech.edu/CaltechAUTHORS:BALmsb08

Haseltine, Eric L. and Arnold, Frances H. (2008) Implications of Rewiring Bacterial Quorum Sensing. Applied and Environmental Microbiology, 74 (2). pp. 437-445. ISSN 0099-2240. PMCID PMC2223271. http://resolver.caltech.edu/CaltechAUTHORS:HASaem08

2007

Fasan, Rudi and Chen, Mike M. and Crook, Nathan C. et al. (2007) Engineered Alkane‐Hydroxylating Cytochrome P450_(BM3) Exhibiting Nativelike Catalytic Properties. Angewandte Chemie International Edition, 46 (44). pp. 8414-8418. ISSN 1433-7851. http://resolver.caltech.edu/CaltechAUTHORS:20180925-122611378

Brenner, Katie and Karig, David K. and Weiss, Ron et al. (2007) Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium. Proceedings of the National Academy of Sciences of the United States of America, 104 (44). pp. 17300-17304. ISSN 0027-8424. PMCID PMC2077251. http://resolver.caltech.edu/CaltechAUTHORS:BREpnas07

Hawkins, Andrew C. and Arnold, Frances H. and Stuermer, Rainer et al. (2007) Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone. Applied and Environmental Microbiology, 73 (18). pp. 5775-5781. ISSN 0099-2240. PMCID PMC2074898. http://resolver.caltech.edu/CaltechAUTHORS:HAWaem07

Li, Yougen and Drummond, D. Allan and Sawayama, Andrew M. et al. (2007) A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments. Nature Biotechnology, 25 (9). pp. 1051-1056. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150317-105811561

Carbone, Martina N. and Arnold, Frances H. (2007) Engineering by homologous recombination: exploring sequence and function within a conserved fold. Current Opinion in Structural Biology, 17 (4). pp. 454-459. ISSN 0959-440X. http://resolver.caltech.edu/CaltechAUTHORS:20180925-112232037

Bloom, Jesse D. and Lu, Zhongyi and Chen, David et al. (2007) Evolution favors protein mutational robustness in sufficiently large populations. BMC Biology, 5 (29). ISSN 1741-7007. PMCID PMC1995189. http://resolver.caltech.edu/CaltechAUTHORS:BLObmcb07

Bloom, Jesse D. and Romero, Philip A. and Lu, Zhongyi et al. (2007) Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution. Biology Direct, 2 . Art. No. 17. ISSN 1745-6150. PMCID PMC1914045. http://resolver.caltech.edu/CaltechAUTHORS:BLObd07

Haseltine, Eric L. and Arnold, Frances H. (2007) Synthetic Gene Circuits: Design with Directed Evolution. Annual Review of Biophysics and Biomolecular Structure, 36 . pp. 1-19. ISSN 1056-8700. http://resolver.caltech.edu/CaltechAUTHORS:HASarbbs07

Landwehr, Marco and Carbone, Martina and Otey, Christopher R. et al. (2007) Diversification of Catalytic Function in a Synthetic Family of Chimeric Cytochrome P450s. Chemistry and Biology, 14 (3). pp. 269-278. ISSN 1074-5521. PMCID PMC1991292. http://resolver.caltech.edu/CaltechAUTHORS:20180821-082843212

Arnold, Frances H. and Moore, Jeffrey C. (2007) Optimizing industrial enzymes by directed evolution. In: New Enzymes for Organic Synthesis: Screening, Supply and Engineering. Advances in Biochemical Engineering/Biotechnology. No.58. Springer , Berlin, pp. 1-14. ISBN 9783540618690. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144310969

Bloom, Jesse D. and Arnold, Frances H. and Wilke, Claus O. (2007) Breaking proteins with mutations: threads and thresholds in evolution. Molecular Systems Biology, 3 (1). Art. No. 76. ISSN 1744-4292. http://resolver.caltech.edu/CaltechAUTHORS:20180820-161436856

2006

Meyer, Michelle M. and Hochrein, Lisa and Arnold, Frances H. (2006) Structure-guided SCHEMA recombination of distantly related β-lactamase. Protein Engineering, Design and Selection, 19 (12). pp. 563-570. ISSN 1741-0126. http://resolver.caltech.edu/CaltechAUTHORS:20180925-132315308

Bloom, Jesse D. and Drummond, D. Allan and Arnold, Frances H. et al. (2006) Structural Determinants of the Rate of Protein Evolution in Yeast. Molecular Biology and Evolution, 23 (9). pp. 1751-1761. ISSN 0737-4038. http://resolver.caltech.edu/CaltechAUTHORS:20180925-124255575

Collins, Cynthia H. and Leadbetter, Jared R. and Arnold, Frances H. (2006) Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR. Nature Biotechnology, 24 (6). pp. 708-712. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20130502-083943317

Landwehr, Marco and Hochrein, Lisa and Otey, Christopher R. et al. (2006) Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3. Journal of the American Chemical Society, 128 (18). pp. 6058-6059. ISSN 0002-7863. PMCID PMC2551755. http://resolver.caltech.edu/CaltechAUTHORS:20170424-103335679

Otey, Christopher R. and Landwehr, Marco and Endelman, Jeffrey B. et al. (2006) Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450. PLoS Biology, 4 (5). e112. ISSN 1544-9173. PMCID PMC1431580. http://resolver.caltech.edu/CaltechAUTHORS:OTEpbio06

Bloom, Jesse D. and Labthavikul, Sy T. and Otey, Christopher R. et al. (2006) Protein stability promotes evolvability. Proceedings of the National Academy of Sciences of the United States of America, 103 (15). pp. 5869-5874. ISSN 0027-8424. PMCID PMC1458665. http://resolver.caltech.edu/CaltechAUTHORS:BLOpnas06

Arnold, Frances H. (2006) Fancy footwork in the sequence space shuffle. Nature Biotechnology, 24 (3). pp. 328-330. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150318-141551432

Udit, Andrew K. and Hill, Michael G. and Bittner, Garrett et al. (2006) Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes. ECS Meeting Abstracts, 501 (1). Abstract 9. ISSN 1091-8213. http://resolver.caltech.edu/CaltechAUTHORS:UDIescm06

Otey, Christopher R. and Bandara, Geethani and Lalonde, James et al. (2006) Preparation of human metabolites of propranolol using laboratory‐evolved bacterial cytochromes P450. Biotechnology and Bioengineering, 93 (3). pp. 494-499. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180821-155634350

Tobias, Alexander V. and Arnold, Frances H. (2006) Biosynthesis of novel carotenoid families based on unnatural carbon backbones: A model for diversification of natural product pathways. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1761 (2). pp. 235-46. ISSN 1388-1981. http://resolver.caltech.edu/CaltechAUTHORS:20170408-160618170

Kubo, Takafumi and Peters, Matthew W. and Meinhold, Peter et al. (2006) Enantioselective Epoxidation of Terminal Alkenes to (R)- and (S)-Epoxides by Engineered Cytochromes P450 BM-3. Chemistry: a European Journal, 12 (4). pp. 1216-1220. ISSN 0947-6539. http://resolver.caltech.edu/CaltechAUTHORS:20180821-153046657

2005

Meinhold, Peter and Peters, Matthew W. and Chen, Michael M. Y. et al. (2005) Direct Conversion of Ethane to Ethanol by Engineered Cytochrome P450 BM3. ChemBioChem, 6 (10). pp. 1765-1768. ISSN 1439-4227. http://resolver.caltech.edu/CaltechAUTHORS:20180824-074157610

Drummond, D. Allan and Bloom, Jesse D. and Adami, Christoph et al. (2005) Why highly expressed proteins evolve slowly. Proceedings of the National Academy of Sciences of the United States of America, 102 (40). pp. 14338-14343. ISSN 0027-8424. PMCID PMC1242296. http://resolver.caltech.edu/CaltechAUTHORS:DRUpnas05b

Bloom, Jesse D. and Meyer, Michelle M. and Meinhold, Peter et al. (2005) Evolving strategies for enzyme engineering. Current Opinion in Structural Biology, 15 (4). pp. 447-452. ISSN 0959-440X. http://resolver.caltech.edu/CaltechAUTHORS:20180823-073228047

Drummond, D. Allan and Iverson, Brent L. and Georgiou, George et al. (2005) Why High-error-rate Random Mutagenesis Libraries are Enriched in Functional and Improved Proteins. Journal of Molecular Biology, 350 (4). pp. 806-816. ISSN 0022-2836. http://resolver.caltech.edu/CaltechAUTHORS:20180821-161657424

Balagaddé, Frederick K. and You, Lingchong and Hansen, Carl L. et al. (2005) Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat. Science, 309 (5731). pp. 137-140. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20141121-103618066

Udit, Andrew K. and Hindoyan, Nareen and Hill, Michael G. et al. (2005) Protein−Surfactant Film Voltammetry of Wild-Type and Mutant Cytochrome P450 BM3. Inorganic Chemistry, 44 (12). pp. 4109-4111. ISSN 0020-1669. http://resolver.caltech.edu/CaltechAUTHORS:20170426-070838205

Basu, Subhayu and Gerchman, Yoram and Collins, Cynthia H. et al. (2005) A synthetic multicellular system for programmed pattern formation. Nature, 434 (7037). pp. 1130-1134. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20150319-084633535

Drummond, D. Allan and Silberg, Jonathan J. and Meyer, Michelle M. et al. (2005) On the conservative nature of intragenic recombination. Proceedings of the National Academy of Sciences of the United States of America, 102 (15). pp. 5380-5385. ISSN 0027-8424. PMCID PMC556249. http://resolver.caltech.edu/CaltechAUTHORS:DRUpnas05a

Münzer, Dieter F. and Meinhold, Peter and Peters, Matthew W. et al. (2005) Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3. Chemical Communications, 2005 (20). pp. 2597-2599. ISSN 1359-7345. http://resolver.caltech.edu/CaltechAUTHORS:MUNcc05

Umeno, Daisuke and Tobias, Alexander V. and Arnold, Frances H. (2005) Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution. Microbiology and Molecular Biology Reviews, 69 (1). pp. 51-78. ISSN 1092-2172. PMCID PMC1082795. http://resolver.caltech.edu/CaltechAUTHORS:UMEmmbr05

Collins, Cynthia H. and Arnold, Frances H. and Leadbetter, Jared R. (2005) Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones. Molecular Microbiology, 55 (3). pp. 712-723. ISSN 0950-382X. http://resolver.caltech.edu/CaltechAUTHORS:COLmm05

Bloom, Jesse D. and Silberg, Jonathan J. and Wilke, Claus O. et al. (2005) Thermodynamic prediction of protein neutrality. Proceedings of the National Academy of Sciences of the United States of America, 102 (3). pp. 606-611. ISSN 0027-8424. PMCID PMC545518. http://resolver.caltech.edu/CaltechAUTHORS:BLOpnas05

2004

Malliaros, Jim and Quinn, Charles and Arnold, Frances H. et al. (2004) Association of antigens to ISCOMATRIX™ adjuvant using metal chelation leads to improved CTL responses. Vaccine, 22 (29-30). pp. 3968-3975. ISSN 0264-410X. http://resolver.caltech.edu/CaltechAUTHORS:20180822-090642552

Udit, Andrew K. and Arnold, Frances H. and Gray, Harry B. (2004) Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3. Journal of Inorganic Biochemistry, 98 (9). pp. 1547-1550. ISSN 0162-0134. http://resolver.caltech.edu/CaltechAUTHORS:20180821-155119382

Udit, Andrew K. and Hill, Michael G. and Bittner, V. Garrett et al. (2004) Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes. Journal of the American Chemical Society, 126 (33). pp. 10218-10219. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20170426-144912333

Silberg, Jonathan J. and Endelman, Jeffrey B. and Arnold, Frances H. (2004) SCHEMA-Guided Protein Recombination. In: Protein Engineering. Methods in Enzymology. No.388. Academic Press , San Diego, CA, pp. 35-42. ISBN 9780121827939. http://resolver.caltech.edu/CaltechAUTHORS:20180821-161122360

Endelman, Jeffrey B. and Silberg, Jonathan J. and Wang, Zhen-Gang et al. (2004) Site-directed protein recombination as a shortest-path problem. Protein Engineering, Design and Selection, 17 (7). pp. 589-594. ISSN 1741-0126. http://resolver.caltech.edu/CaltechAUTHORS:20111012-101511149

Bloom, Jesse D. and Wilke, Claus O. and Arnold, Frances H. et al. (2004) Stability and the Evolvability of Function in a Model Protein. Biophysical Journal, 86 (5). pp. 2758-2764. ISSN 0006-3495. PMCID PMC1304146. http://resolver.caltech.edu/CaltechAUTHORS:20180823-073709439

You, Lingchong and Cox, Robert Sidney, III and Weiss, Ron et al. (2004) Programmed population control by cell-cell communication and regulated killing. Nature, 428 (6985). pp. 868-871. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20150327-140146311

Alcalde, Miguel and Farinas, Edgardo T. and Arnold, Frances H. (2004) Colorimetric High-Throughput Assay for Alkene Epoxidation Catalyzed by Cytochrome P450 BM-3 Variant 139-3. Journal of Biomolecular Screening, 9 (2). pp. 141-146. ISSN 1087-0571. http://resolver.caltech.edu/CaltechAUTHORS:20180824-100531408

Umeno, Daisuke and Arnold, Frances H. (2004) Evolution of a Pathway to Novel Long-Chain Carotenoids. Journal of Bacteriology, 186 (5). pp. 1531-1536. ISSN 0021-9193. PMCID PMC344396. http://resolver.caltech.edu/CaltechAUTHORS:UMEjbact04

Otey, Christopher R. and Silberg, Jonathan J. and Voigt, Christopher A. et al. (2004) Functional Evolution and Structural Conservation in Chimeric Cytochromes P450: Calibrating a Structure-Guided Approach. Chemistry and Biology, 11 (3). pp. 309-318. ISSN 1074-5521. http://resolver.caltech.edu/CaltechAUTHORS:20180821-150058089

Wong, Tuck Seng and Arnold, Frances H. and Schwaneberg, Ulrich (2004) Laboratory evolution of cytochrome P450 BM-3 monooxygenase for organic cosolvents. Biotechnology and Bioengineering, 85 (3). pp. 351-358. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180824-074645775

2003

Aguinaldo, Anna Marie and Arnold, Frances H. (2003) Staggered Extension Process (StEP) In Vitro Recombination. In: Directed Evolution Library Creation: Methods and Protocols. Methods in Molecular Biology. No.231. Humana Press , Totowa, NJ, pp. 105-110. ISBN 159259395X. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726328

Peters, Matthew W. and Meinhold, Peter and Glieder, Anton et al. (2003) Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3. Journal of the American Chemical Society, 125 (44). pp. 13442-13450. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20170515-134122486

Cirino, Patrick C. and Tang, Yi and Takahashi, Katsuyuki et al. (2003) Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity. Biotechnology and Bioengineering, 83 (6). pp. 729-734. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:CIRbb2003

Salazar, Oriana and Cirino, Patrick C. and Arnold, Frances H. (2003) Thermostabilization of a Cytochrome P450 Peroxygenase. ChemBioChem, 4 (9). pp. 891-893. ISSN 1439-4227. http://resolver.caltech.edu/CaltechAUTHORS:20180823-094121427

Umeno, Daisuke and Hiraga, Kaori and Arnold, Frances H. (2003) Method to protect a targeted amino acid residue during random mutagenesis. Nucleic Acids Research, 31 (16). e91. ISSN 0305-1048. PMCID PMC169983. http://resolver.caltech.edu/CaltechAUTHORS:UMEnar03

Collins, Cynthia H. and Yokobayashi, Yohei and Umeno, Daisuke et al. (2003) Engineering proteins that bind, move, make and break DNA. Current Opinion in Biotechnology, 14 (4). pp. 371-378. ISSN 0958-1669 . http://resolver.caltech.edu/CaltechAUTHORS:20180823-074749923

Meyer, Michelle M. and Silberg, Jonathan J. and Voigt, Christopher A. et al. (2003) Library analysis of SCHEMA-guided protein recombination. Protein Science, 12 (8). pp. 1686-1693. ISSN 0961-8368. PMCID PMC2323955. http://resolver.caltech.edu/CaltechAUTHORS:20110913-173426256

Cirino, Patrick C. and Arnold, Frances H. (2003) A Self-Sufficient Peroxide-Driven Hydroxylation Biocatalyst. Angewandte Chemie International Edition, 42 (28). pp. 3299-3301. ISSN 1433-7851. http://resolver.caltech.edu/CaltechAUTHORS:20180822-145522004

Hiraga, Kaori and Arnold, Frances H. (2003) General Method for Sequence-independent Site-directed Chimeragenesis. Journal of Molecular Biology, 330 (2). pp. 287-296. ISSN 0022-2836. http://resolver.caltech.edu/CaltechAUTHORS:20180822-085748088

Umeno, Daisuke and Arnold, Frances H. (2003) A C35 Carotenoid Biosynthetic Pathway. Applied and Environmental Microbiology, 69 (6). pp. 3573-3579. ISSN 0099-2240. PMCID PMC161527. http://resolver.caltech.edu/CaltechAUTHORS:UMEaem03

Wintrode, Patrick L. and Zhang, Deqiang and Vaidehi, Nagarajan et al. (2003) Protein Dynamics in a Family of Laboratory Evolved Thermophilic Enzymes. Journal of Molecular Biology, 327 (3). pp. 745-757. ISSN 0022-2836. http://resolver.caltech.edu/CaltechAUTHORS:20180823-075442841

Yokobayashi, Yohei and Collins, Cynthia H. and Leadbetter, Jared R. et al. (2003) Evolutionary Design Of Genetic Circuits And Cell-Cell Communications. Advances in Complex Systems, 6 (1). pp. 37-45. ISSN 0219-5259. http://resolver.caltech.edu/CaltechAUTHORS:20130509-113808728

Bulter, Thomas and Alcalde, Miguel and Sieber, Volker et al. (2003) Functional Expression of a Fungal Laccase in Saccharomyces cerevisiae by Directed Evolution. Applied and Environmental Microbiology, 69 (2). pp. 987-995. ISSN 0099-2240. PMCID PMC143632. http://resolver.caltech.edu/CaltechAUTHORS:BULaem03

2002

Yokobayashi, Yohei and Weiss, Ron and Arnold, Frances H. (2002) Directed evolution of a genetic circuit. Proceedings of the National Academy of Sciences of the United States of America, 99 (26). pp. 16587-16591. ISSN 0027-8424. PMCID PMC139187. http://resolver.caltech.edu/CaltechAUTHORS:YOKpnas02

Alcalde, Miguel and Bulter, Thomas and Arnold, Frances H. (2002) Colorimetric Assays for Biodegradation of Polycyclic Aromatic Hydrocarbons by Fungal Laccases. Journal of Biomolecular Screening, 7 (6). pp. 547-553. ISSN 1087-0571. http://resolver.caltech.edu/CaltechAUTHORS:20180824-095915317

Umeno, Daisuke and Tobias, Alexander V. and Arnold, Frances H. (2002) Evolution of the C30 Carotenoid Synthase CrtM for Function in a C40 Pathway. Journal of Bacteriology, 184 (23). pp. 6690-6699. ISSN 0021-9193. PMCID PMC135437. http://resolver.caltech.edu/CaltechAUTHORS:UMEjbact02

Glieder, Anton and Farinas, Edgardo T. and Arnold, Frances H. (2002) Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase. Nature Biotechnology, 20 (11). pp. 1135-1139. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150513-102744634

Cirino, Patrick C. and Arnold, Frances H. (2002) Regioselectivity and Activity of Cytochrome P450 BM-3 and Mutant F87A in Reactions Driven by Hydrogen Peroxide. Advanced Synthesis and Catalysis, 344 (9). pp. 932-937. ISSN 1615-4150. http://resolver.caltech.edu/CaltechAUTHORS:20180823-093530127

Sun, Lianhong and Bulter, Thomas and Alcalde, Miguel et al. (2002) Modification of Galactose Oxidase to Introduce Glucose 6-Oxidase Activity. ChemBioChem, 3 (8). pp. 781-783. ISSN 1439-4227. http://resolver.caltech.edu/CaltechAUTHORS:20180822-135954922

Voigt, Christopher A. and Martinez, Carlos and Wang, Zhen-Gang et al. (2002) Protein building blocks preserved by recombination. Nature Structural Biology, 9 (7). pp. 553-558. ISSN 1072-8368 . http://resolver.caltech.edu/CaltechAUTHORS:20110927-143229047

Fu, Anne Y. and Chou, Hou-Pu and Spence, Charles et al. (2002) An Integrated Microfabricated Cell Sorter. Analytical Chemistry, 74 (11). pp. 2451-2457. ISSN 0003-2700. http://resolver.caltech.edu/CaltechAUTHORS:20160818-154108271

Mayer, Kimberly M. and Arnold, Frances H. (2002) A Colorimetric Assay to Quantify Dehydrogenase Activity in Crude Cell Lysates. Journal of Biomolecular Screening, 7 (2). pp. 135-140. ISSN 1087-0571. http://resolver.caltech.edu/CaltechAUTHORS:20180830-094750468

Cirino, Patrick C. and Arnold, Frances H. (2002) Protein engineering of oxygenases for biocatalysis. Current Opinion in Chemical Biology, 6 (2). pp. 130-135. ISSN 1367-5931. http://resolver.caltech.edu/CaltechAUTHORS:20180822-091542901

Joern, John M and Meinhold, Peter and Arnold, Frances H. (2002) Analysis of shuffled gene libraries. Journal of Molecular Biology, 316 (3). pp. 643-656. ISSN 0022-2836. http://resolver.caltech.edu/CaltechAUTHORS:20170408-161123738

Cirino, Patrick C. and Arnold, Frances H. (2002) Exploring the Diversity of Heme Enzymes through Directed Evolution. In: Directed Molecular Evolution of Proteins: or How to Improve Enzymes for Biocatalysis. Wiley-VCH , Weinheim, pp. 215-243. ISBN 9783527304233. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140907352

2001

Farinas, Edgardo T. and Bulter, Thomas and Arnold, Frances H. (2001) Directed enzyme evolution. Current Opinion in Biotechnology, 12 (6). pp. 545-551. ISSN 0958-1669 . http://resolver.caltech.edu/CaltechAUTHORS:20180822-075727932

Wintrode, Patrick L. and Miyazaki, Kentaro and Arnold, Frances H. (2001) Patterns of adaptation in a laboratory evolved thermophilic enzyme. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1549 (1). pp. 1-8. ISSN 0167-4838. http://resolver.caltech.edu/CaltechAUTHORS:20180822-085420199

Sun, Lianhong and Petrounia, Ioanna P. and Yagasaki, Makoto et al. (2001) Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution. Protein Engineering, 14 (9). pp. 699-704. ISSN 0269-2139. http://resolver.caltech.edu/CaltechAUTHORS:20111121-101225836

Morawski, Birgit and Quan, Sara and Arnold, Frances H. (2001) Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae. Biotechnology and Bioengineering, 76 (2). pp. 99-107. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180824-083058588

Sakamoto, Takeshi and Joern, John M. and Arisawa, Akira et al. (2001) Laboratory Evolution of Toluene Dioxygenase To Accept 4-Picoline as a Substrate. Applied and Environmental Microbiology, 67 (9). pp. 3882-3887. ISSN 0099-2240. PMCID PMC93105. http://resolver.caltech.edu/CaltechAUTHORS:SAKaem01

Joern, John M. and Sakamoto, Takeshi and Arisawa, Akira et al. (2001) A Versatile High Throughput Screen for Dioxygenase Activity Using Solid-Phase Digital Imaging. Journal of Biomolecular Screening, 6 (4). pp. 219-223. ISSN 1087-0571. http://resolver.caltech.edu/CaltechAUTHORS:20180824-101334951

Farinas, Edgardo T. and Schwaneberg, Ulrich and Glieder, Anton et al. (2001) Directed Evolution of a Cytochrome P450 Monooxygenase for Alkane Oxidation. Advanced Synthesis and Catalysis, 343 (6-7). pp. 601-606. ISSN 1615-4150. http://resolver.caltech.edu/CaltechAUTHORS:20180822-144646102

Sieber, Volker and Martinez, Carlos A. and Arnold, Frances H. (2001) Libraries of hybrid proteins from distantly related sequences. Nature Biotechnology, 19 (5). pp. 456-460. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20181113-135322855

Thorsen, Todd and Roberts, Richard W. and Arnold, Frances H. et al. (2001) Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device. Physical Review Letters, 86 (18). pp. 4163-4166. ISSN 0031-9007. http://resolver.caltech.edu/CaltechAUTHORS:THOprl01

Schwaneberg, Ulrich and Otey, Christopher and Cirino, Patrick C. et al. (2001) Cost-Effective Whole-Cell Assay for Laboratory Evolution of Hydroxylases in Escherichia coli. Journal of Biomolecular Screening, 6 (2). pp. 111-117. ISSN 1087-0571. http://resolver.caltech.edu/CaltechAUTHORS:20180824-101913620

Voigt, Christopher A. and Mayo, Stephen L. and Arnold, Frances H. et al. (2001) Computational method to reduce the search space for directed protein evolution. Proceedings of the National Academy of Sciences of the United States of America, 98 (7). pp. 3778-3783. ISSN 0027-8424. PMCID PMC31129. http://resolver.caltech.edu/CaltechAUTHORS:VOIpnas01

Arnold, Frances H. (2001) Combinatorial and computational challenges for biocatalyst design. Nature, 409 (6817). pp. 253-257. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20150325-160247369

Voigt, Christopher A. and Mayo, Stephen L. and Arnold, Frances H. et al. (2001) Computationally Focusing the Directed Evolution of Proteins. Journal of Cellular Biochemistry, 84 (S37). pp. 58-63. ISSN 0730-2312. http://resolver.caltech.edu/CaltechAUTHORS:20110927-154155139

Arnold, Frances H. (2001) Evolutionary Protein Design. Advances in Protein Chemistry. Vol.55. Academic Press , San Diego, CA. ISBN 978-0-12-034255-6. http://resolver.caltech.edu/CaltechAUTHORS:20180823-142414677

Arnold, Frances H. (2001) Preface. In: Evolutionary Protein Design. Advances in Protein Chemistry. No.55. Elsevier , New York, NY, ix-xi. ISBN 9780120342556. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726417

Wintrode, Patrick L. and Arnold, Frances H. (2001) Temperature adaptation of enzymes: Lessons from laboratory evolution. In: Evolutionary Protein Design. Advances in Protein Chemistry. No.55. Elsevier , New York, NY, pp. 161-225. ISBN 9780120342556. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726495

2000

Wintrode, Patrick L. and Miyazaki, Kentaro and Arnold, Frances H. (2000) Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution. Journal of Biological Chemistry, 275 (41). pp. 31635-31640. ISSN 0021-9258. http://resolver.caltech.edu/CaltechAUTHORS:WINjbc00

Petrounia, Ioanna P. and Arnold, Frances H. (2000) Designed evolution of enzymatic properties. Current Opinion in Biotechnology, 11 (4). pp. 325-330. ISSN 0958-1669 . http://resolver.caltech.edu/CaltechAUTHORS:20180823-155805952

Schmidt-Dannert, Claudia and Umeno, Daisuke and Arnold, Frances H. (2000) Molecular breeding of carotenoid biosynthetic pathways. Nature Biotechnology, 18 (7). pp. 750-753. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150407-151935752

Morawski, Birgit and Lin, Zhanglin and Cirino, Pat et al. (2000) Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris. Protein Engineering, 13 (5). pp. 377-384. ISSN 0269-2139 . http://resolver.caltech.edu/CaltechAUTHORS:20111201-083504577

Gershenson, Anne and Schauerte, Joseph A. and Giver, Lori et al. (2000) Tryptophan Phosphorescence Study of Enzyme Flexibility and Unfolding in Laboratory-Evolved Thermostable Esterases. Biochemistry, 39 (16). pp. 4658-4665. ISSN 0006-2960. http://resolver.caltech.edu/CaltechAUTHORS:20170201-092852593

Miyazaki, Kentaro and Wintrode, Patrick L. and Grayling, Rowan A. et al. (2000) Directed evolution study of temperature adaptation in a psychrophilic enzyme. Journal of Molecular Biology, 297 (4). pp. 1015-1026. ISSN 0022-2836. http://resolver.caltech.edu/CaltechAUTHORS:20180823-155805725

May, Oliver and Nguyen, Peter T. and Arnold, Frances H. (2000) Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine. Nature Biotechnology, 18 (3). pp. 317-320. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150325-154133315

1999

Miyazaki, Kentaro and Arnold, Frances H. (1999) Exploring Nonnatural Evolutionary Pathways by Saturation Mutagenesis: Rapid Improvement of Protein Function. Journal of Molecular Evolution, 49 (6). pp. 716-720. ISSN 0022-2844. http://resolver.caltech.edu/CaltechAUTHORS:20180823-155805865

Michnick, Stephen W. and Arnold, Frances H. (1999) “Itching” for new strategies in protein engineering. Nature Biotechnology, 17 (12). pp. 1159-1160. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150513-144855903

Gillam, Elizabeth M. J. and Aguinaldo, Anna Marie A. and Notley, Lisa M. et al. (1999) Formation of Indigo by Recombinant Mammalian Cytochrome P450. Biochemical and Biophysical Research Communications, 265 (2). pp. 469-472. ISSN 0006-291X. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144310509

Fu, Anne Y. and Spence, Charles and Scherer, Axel et al. (1999) A microfabricated fluorescence-activated cell sorter. Nature Biotechnology, 17 (11). pp. 1109-1111. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20111101-071340837

Spiller, Ben and Gershenson, Anne and Arnold, Frances H. et al. (1999) A structural view of evolutionary divergence. Proceedings of the National Academy of Sciences of the United States of America, 96 (22). pp. 12305-12310. ISSN 0027-8424. PMCID PMC22912. http://resolver.caltech.edu/CaltechAUTHORS:SPIpnas99

Joo, Hyun and Arisawa, Akira and Lin, Zhanglin et al. (1999) A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases. Chemistry and Biology, 6 (10). pp. 699-706. ISSN 1074-5521. http://resolver.caltech.edu/CaltechAUTHORS:20180822-141412954

Volkov, Alexander A. and Shao, Zhixin and Arnold, Frances H. (1999) Recombination and chimeragenesis by in vitro heteroduplex formation and in vivo repair. Nucleic Acids Research, 27 (18). e18. ISSN 0305-1048. PMCID PMC148610. http://resolver.caltech.edu/CaltechAUTHORS:VOLnar99

Joo, Hyun and Lin, Zhanglin and Arnold, Frances H. (1999) Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation. Nature, 399 (6737). pp. 670-673. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20150616-090039521

Arnold, Frances H. and Giver, Lori and Gershenson, Anne et al. (1999) Directed Evolution of Mesophilic Enzymes into Their Thermophilic Counterparts. Annals of the New York Academy of Sciences, 870 (1). pp. 400-403. ISSN 0077-8923. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144310697

Lin, Zhanglin and Thorsen, Todd and Arnold, Frances H. (1999) Functional Expression of Horseradish Peroxidase in E. coli by Directed Evolution. Biotechnology Progress, 15 (3). pp. 467-471. ISSN 8756-7938. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144310796

Schmidt-Dannert, Claudia and Arnold, Frances H. (1999) Directed evolution of industrial enzymes. Trends in Biotechnology, 17 (4). pp. 135-136. ISSN 0167-7799. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144310884

Arnold, Frances H. and Volkov, Alexander A. (1999) Directed evolution of biocatalysts. Current Opinion in Chemical Biology, 3 (1). pp. 54-59. ISSN 1367-5931. http://resolver.caltech.edu/CaltechAUTHORS:20180822-160718852

Zhao, Huimin and Arnold, Frances H. (1999) Directed evolution converts subtilisin E into a functional equivalent of thermitase. Protein Engineering, 12 (1). pp. 47-53. ISSN 0269-2139. http://resolver.caltech.edu/CaltechAUTHORS:ZHApeds99

Arnold, Frances H. and Wintrode, Patrick L. (1999) Enzymes, Directed Evolution. In: Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis, and Bioseparation. John Wiley & Sons, Inc. , Hoboken, NJ, Art. No. 80. ISBN 0471250589. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140907434

Joo, Hyun and Lin, Zhanglin and Arnold, Frances H. et al. (1999) Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation. Redox Report, 4 (5). pp. 195-197. ISSN 1351-0002. http://resolver.caltech.edu/CaltechAUTHORS:20150619-100151141

1998

Giver, Lori and Gershenson, Anne and Freskgard, Per-Ola et al. (1998) Directed evolution of a thermostable esterase. Proceedings of the National Academy of Sciences of the United States of America, 95 (22). pp. 12809-12813. ISSN 0027-8424. PMCID PMC23604. http://resolver.caltech.edu/CaltechAUTHORS:GIVpnas98

Arnold, Frances H. (1998) When blind is better: Protein design by evolution. Nature Biotechnology, 16 (7). pp. 617-618. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150618-090928982

Giver, Lori and Arnold, Frances H. (1998) Combinatorial protein design by in vitro recombination. Current Opinion in Chemical Biology, 2 (3). pp. 335-338. ISSN 1367-5931. http://resolver.caltech.edu/CaltechAUTHORS:20180822-085113552

Arnold, Frances H. and Striegler, Susanne and Sundaresan, Vidyasankar (1998) Chiral Ligand Exchange Adsorbents for Amines and Underivatized Amino Acids: 'Bait-and-Switch' Molecular Imprinting. In: Molecular and Ionic Recognition with Imprinted Polymers. ACS Symposium Series. No.703. American Chemical Society , Washington, DC, pp. 109-118. ISBN 9780841235748. http://resolver.caltech.edu/CaltechAUTHORS:20180406-091535284

Arnold, Frances H. (1998) Enzyme engineering reaches the boiling point. Proceedings of the National Academy of Sciences of the United States of America, 95 (5). pp. 2035-2036. ISSN 0027-8424. PMCID PMC33840. http://resolver.caltech.edu/CaltechAUTHORS:ARNpnas98

Arnold, Frances H. (1998) Design by Directed Evolution. Accounts of Chemical Research, 31 (3). pp. 125-131. ISSN 0001-4842. http://resolver.caltech.edu/CaltechAUTHORS:20171108-085419178

Zhao, Huimin and Giver, Lori and Shao, Zhixin et al. (1998) Molecular evolution by staggered extension process (StEP) in vitro recombination. Nature Biotechnology, 16 (3). pp. 258-261. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150618-135325510

Shao, Zhixin and Zhao, Huimin and Giver, Lori et al. (1998) Random-priming in vitro recombination: an effective tool for directed evolution. Nucleic Acids Research, 26 (2). pp. 681-683. ISSN 0305-1048. PMCID PMC147287. http://resolver.caltech.edu/CaltechAUTHORS:SHAnar98

1997

Kuchner, Olga and Arnold, Frances H. (1997) Directed evolution of enzyme catalysts. Trends in Biotechnology, 15 (12). pp. 523-530. ISSN 0167-7799. http://resolver.caltech.edu/CaltechAUTHORS:20180822-161250434

Moore, Jeffrey C. and Jin, Hua-Ming and Kuchner, Olga et al. (1997) Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences. Journal of Molecular Biology, 272 (3). pp. 336-347. ISSN 0022-2836. http://resolver.caltech.edu/CaltechAUTHORS:20180822-090200824

Zhao, Huimin and Arnold, Frances H. (1997) Combinatorial protein design: strategies for screening protein libraries. Current Opinion in Structural Biology, 7 (4). pp. 480-485. ISSN 0959-440X. http://resolver.caltech.edu/CaltechAUTHORS:20180823-111025299

Zhao, Huimin and Arnold, Frances H. (1997) Functional and nonfunctional mutations distinguished by random recombination of homologous genes. Proceedings of the National Academy of Sciences of the United States of America, 94 (15). pp. 7997-8000. ISSN 0027-8424. PMCID PMC21544. http://resolver.caltech.edu/CaltechAUTHORS:ZHApnas97

Pack, Daniel W. and Arnold, Frances H. (1997) Langmuir monolayer characterization of metal chelating lipids for protein targeting to membranes. Chemistry and Physics of Lipids, 86 (2). pp. 135-152. ISSN 0009-3084. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726582

Chen, G. and Guan, Z. and Chen, C.-T. et al. (1997) A glucose sensing polymer. Abstracts of Papers of the American Chemical Society, 213 . 176-ANYL. ISSN 0065-7727 . http://resolver.caltech.edu/CaltechAUTHORS:20150624-081132570

Chen, G. and Guan, Z. and Chen, C.-T. et al. (1997) A glucose-sensing polymer. Abstracts of Papers of the American Chemical Society, 213 . 234-PMSE. ISSN 0065-7727 . http://resolver.caltech.edu/CaltechAUTHORS:20150623-100021833

Chen, Guohua and Guan, Zhibin and Chen, Chao-Tsen et al. (1997) A glucose-sensing polymer. Nature Biotechnology, 15 (4). pp. 354-357. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150618-141848730

Zhao, Huimin and Arnold, Frances H. (1997) Optimization of DNA shuffling for high fidelity recombination. Nucleic Acids Research, 25 (6). pp. 1307-1308. ISSN 0305-1048. PMCID PMC146579. http://resolver.caltech.edu/CaltechAUTHORS:ZHAnar97

Pack, Daniel W. and Chen, Guohua and Maloney, Kevin M. et al. (1997) A Metal-Chelating Lipid for 2D Protein Crystallization via Coordination of Surface Histidines. Journal of the American Chemical Society, 119 (10). pp. 2479-2487. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20180801-090115992

1996

Zhao, Huimin and Li, You and Arnold, Frances H. (1996) Strategy for the Directed Evolution of a Peptide Ligase. Annals of the New York Academy of Sciences, 799 (1). pp. 1-5. ISSN 0077-8923. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144311065

Shao, Zhixin and Arnold, Frances H. (1996) Engineering new functions and altering existing functions. Current Opinion in Structural Biology, 6 (4). pp. 513-518. ISSN 0959-440X. http://resolver.caltech.edu/CaltechAUTHORS:20180822-084814588

Frey, Wolfgang and Schief, William R., Jr. and Pack, Daniel W. et al. (1996) Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines. Proceedings of the National Academy of Sciences of the United States of America, 93 (10). pp. 4937-4941. ISSN 0027-8424. PMCID PMC39383. http://resolver.caltech.edu/CaltechAUTHORS:FREpnas96

Moore, Jeffrey C. and Arnold, Frances H. (1996) Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents. Nature Biotechnology, 14 (4). pp. 458-467. ISSN 1087-0156. http://resolver.caltech.edu/CaltechAUTHORS:20150618-143020949

Johnson, R. D. and Wang, Z.-G. and Arnold, F. H. (1996) Surface Site Heterogeneity and Lateral Interactions in Multipoint Protein Adsorption. Journal of Physical Chemistry, 100 (12). pp. 5134-5139. ISSN 0022-3654 . http://resolver.caltech.edu/CaltechAUTHORS:20180720-141711681

Johnson, Robert D. and Todd, Robert J. and Arnold, Frances H. (1996) Multipoint binding in metal-affinity chromatography: II. Effect of pH and imidazole on chromatographic retention of engineered histidine-containing cytochromes c. Journal of Chromatography A, 725 (2). pp. 225-235. ISSN 0021-9673. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144311160

You, L. and Arnold, F. H. (1996) Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide. Protein Engineering, 9 (1). pp. 77-83. ISSN 0269-2139. http://resolver.caltech.edu/CaltechAUTHORS:20170408-195328283

1995

Johnson, Robert D. and Arnold, Frances H. (1995) Review: Multipoint binding and heterogeneity in immobilized metal affinity chromatography. Biotechnology and Bioengineering, 48 (5). pp. 437-443. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726673

Vidyasankar, Sundaresan and Dhal, Pradeep K. and Plunkett, Sean D. et al. (1995) Review: Selective ligand-exchange adsorbents prepared by template polymerization. Biotechnology and Bioengineering, 48 (5). pp. 431-436. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726758

Ng, Kingman and Pack, Daniel W. and Sasaki, Darryl Y. et al. (1995) Engineering Protein-Lipid Interactions: Targeting of Histidine-Tagged Proteins to Metal-Chelating Lipid Monolayers. Langmuir, 11 (10). pp. 4048-4055. ISSN 0743-7463. http://resolver.caltech.edu/CaltechAUTHORS:20180720-135831089

Plunkett, Sean D. and Arnold, Frances H. (1995) Molecularly imprinted polymers on silica: selective supports for high-performance ligand-exchange chromatography. Journal of Chromatography A, 708 (1). pp. 19-29. ISSN 0021-9673. http://resolver.caltech.edu/CaltechAUTHORS:20180822-075236331

Sasaki, Darryl Y. and Shnek, Deborah R. and Pack, Daniel W. et al. (1995) Metal-Induced Dispersion of Lipid Aggregates: A Simple, Selective, and Sensitive Fluorescent Metal Ion Sensor. Angewandte Chemie International Edition, 34 (8). pp. 905-907. ISSN 1433-7851. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144311536

Johnson, Robert D. and Arnold, Frances H. (1995) The temkin isotherm describes heterogeneous protein adsorption. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1247 (2). pp. 293-297. ISSN 0167-4838. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144019749

1994

Shnek, D. R. and Pack, D. W. and Sasaki, D. Y. et al. (1994) Specific Protein Attachment to Artificial Membranes via Coordination to Lipid-Bound Copper(II). Langmuir, 10 (7). pp. 2382-2388. ISSN 0743-7463. http://resolver.caltech.edu/CaltechAUTHORS:20180530-153931465

Arnold, Frances H. and Zhang, Ji-Hu (1994) Metal-mediated protein stabilization. Trends in Biotechnology, 12 (5). pp. 189-192. ISSN 0167-7799. http://resolver.caltech.edu/CaltechAUTHORS:20180822-161848179

Todd, Robert J. and Johnson, Robert D. and Arnold, Frances H. (1994) Multiple-site binding interactions in metal-affinity chromatography: I. Equilibrium binding of engineered histidine-containing cytochromes c. Journal of Chromatography A, 662 (1). pp. 13-26. ISSN 0021-9673. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144311357

Chung, Bong H. and Bailey, Darwin and Arnold, Frances H. (1994) Metal affinity partitioning. In: Aqueous Two-Phase Systems. Methods in Enzymology. No.228. Academic Press , San Diego, CA, pp. 167-179. ISBN 9780121821296. http://resolver.caltech.edu/CaltechAUTHORS:20180823-084045820

1993

Arnold, Frances H. and Chen, Keqin and Economou, Chara et al. (1993) Engineering Nonaqueous Solvent-Compatible Enzymes. In: Biocatalyst Design for Stability and Specificity. ACS Symposium Series. No.516. American Chemical Society , Washington, DC, pp. 109-113. ISBN 9780841225183. http://resolver.caltech.edu/CaltechAUTHORS:20180405-140056909

Umaña, Pablo and Kellis, James T. and Arnold, Frances H. (1993) Recombinant Protein Stabilization through Engineered Metal-Chelating Sites. In: Biocatalyst Design for Stability and Specificity. ACS Symposium Series. No.516. American Chemical Society , Washington, DC, pp. 102-108. ISBN 9780841225183. http://resolver.caltech.edu/CaltechAUTHORS:20180405-145415327

Arnold, Frances H. (1993) Protein engineering for unusual environments. Current Opinion in Biotechnology, 4 (4). pp. 450-455. ISSN 0958-1669. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144311446

Arnold, F. H. (1993) Engineering proteins for nonnatural environments. FASEB Journal, 7 (9). pp. 744-749. ISSN 0892-6638. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726856

Chen, Keqin and Arnold, Frances H. (1993) Tuning the Activity of an Enzyme for Unusual Environments: Sequential Random Mutagenesis of Subtilisin E for Catalysis in Dimethylformamide. Proceedings of the National Academy of Sciences of the United States of America, 90 (6). pp. 5618-5622. ISSN 0027-8424. PMCID PMC46772. http://resolver.caltech.edu/CaltechAUTHORS:CHEpnas93

Mallik, Sanku and Johnson, Robert D. and Arnold, Frances H. (1993) Selective recognition of bis-imidazoles by complementary bis-metal ion complexes. Journal of the American Chemical Society, 115 (6). pp. 2518-2520. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20170808-131101814

1992

Dhal, Pradeep K. and Arnold, Frances H. (1992) Metal-coordination interactions in the template-mediated synthesis of substrate-selective polymers: recognition of bis(imidazole) substrates by copper(II) iminodiacetate containing polymers. Macromolecules, 25 (25). pp. 7051-7059. ISSN 0024-9297. http://resolver.caltech.edu/CaltechAUTHORS:20180720-124935431

Economou, Chariklia and Chen, Keqin and Arnold, Frances H. (1992) Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E. Biotechnology and Bioengineering, 39 (6). pp. 658-662. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140726943

Martinez, Pascal and Van Dam, Mariana E. and Robinson, Amy C. et al. (1992) Stabilization of substilisin E in organic solvents by site-directed mutagenesis. Biotechnology and Bioengineering, 39 (2). pp. 141-147. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140907258

Martinez, Pascal and Van Dam, Mariana E. and Robinson, Amy C. et al. (1992) Stabilization of substilisin E in organic solvents by site‐directed mutagenesis. Biotechnology and Bioengineering, 39 (2). pp. 141-147. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180822-162145517

1991

Chen, Keqin and Arnold, Frances H. (1991) Enzyme Engineering for Nonaqueous Solvents: Random Mutagenesis to Enhance Activity of Subtilisin E in Polar Organic Media. Bio/Technology, 9 (11). pp. 1073-1077. ISSN 0733-222X. http://resolver.caltech.edu/CaltechAUTHORS:20181113-134920984

Kellis, James T., Jr. and Todd, Robert J. and Arnold, Frances H. (1991) Protein Stabilization by Engineered Metal Chelation. Bio/Technology, 9 (10). pp. 994-995. ISSN 0733-222X. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140907669

Dhal, Pradeep K. and Arnold, Frances H. (1991) Template-mediated synthesis of metal-complexing polymers for molecular recognition. Journal of the American Chemical Society, 113 (19). pp. 7417-7418. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20180515-142255603

Arnold, Frances H. and Haymore, Barry L. (1991) Engineered metal-binding proteins: purification to protein folding. Science, 252 (5014). pp. 1796-1797. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20141215-105527216

Chen, Keqin and Robinson, Amy C. and Van Dam, Mariana E. et al. (1991) Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media. Biotechnology Progress, 7 (2). pp. 125-129. ISSN 8756-7938. http://resolver.caltech.edu/CaltechAUTHORS:20171121-065828114

Suh, Sung-Sup and Haymore, Barry L. and Arnold, Frances H. (1991) Characterization of His-X_3-His sites in α-helices of synthetic metal-binding bovine somatotropin. Protein Engineering, Design and Selection, 4 (3). pp. 301-305. ISSN 1741-0126. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140907750

Todd, Robert J. and Van Dam, Mariana E. and Casimiro, Danilo et al. (1991) Cu(II)-Binding properties of a cytochrome c with a synthetic metal-binding site: His-X_3-His in an α-helix. Proteins, 10 (2). pp. 156-161. ISSN 0887-3585 . http://resolver.caltech.edu/CaltechAUTHORS:20180822-141010187

Arnold, Frances H. (1991) Metal-Affinity Separations: A New Dimension in Protein Processing. Bio/Technology, 9 (2). pp. 151-156. ISSN 0733-222X. http://resolver.caltech.edu/CaltechAUTHORS:20180822-141010067

Wuenschell, G. E. and Wen, E. and Todd, R. et al. (1991) Chiral copper—chelate complexes alter selectivities in metal affinity protein partitioning. Journal of Chromatography A, 543 . pp. 345-354. ISSN 0021-9673. http://resolver.caltech.edu/CaltechAUTHORS:20180822-143031530

1990

Arnold, Frances H. (1990) Engineering enzymes for non-aqueous solvents. Trends in Biotechnology, 8 (9). pp. 244-249. ISSN 0167-7799. http://resolver.caltech.edu/CaltechAUTHORS:20180822-160257032

Suh, S.-S. and Van Dam, M. E. and Wuenschell, G. E. et al. (1990) Novel Metal-Affinity Protein Separations. In: Protein Purification. ACS Symposium Series. No.427. American Chemical Society , Washington, DC, pp. 139-149. http://resolver.caltech.edu/CaltechAUTHORS:20180405-104511502

Suh, Sung-Sup and Arnold, Frances H. (1990) A mathematical model for metal affinity protein partitioning. Biotechnology and Bioengineering, 35 (7). pp. 682-690. ISSN 0006-3592. http://resolver.caltech.edu/CaltechAUTHORS:20180329-160928761

1989

Claeys, Ivan L. and Arnold, Frances H. (1989) Nuclear magnetic relaxation study of hindered rotational diffusion in gels. AIChE Journal, 35 (2). pp. 335-338. ISSN 0001-1541. http://resolver.caltech.edu/CaltechAUTHORS:20180822-140906987

1987

Arnold, Frances H. and Wolk, Steven and Cruz, Phillip et al. (1987) Structure, dynamics, and thermodynamics of mismatched DNA oligonucleotide duplexes d(CCCAGGG)_2 and d(CCCTGGG)_2. Biochemistry, 26 (13). pp. 4068-4075. ISSN 0006-2960. http://resolver.caltech.edu/CaltechAUTHORS:20180822-111107897

1986

Arnold, F. H. and Schofield, S. A. and Blanch, H. W. (1986) Analytical affinity chromatography: I. Local equilibrium theory and the measurement of association and inhibition constants. Journal of Chromatography A, 355 . pp. 1-12. ISSN 0021-9673. http://resolver.caltech.edu/CaltechAUTHORS:20180823-144311722

Arnold, F. H. and Blanch, H. W. (1986) Analytical affinity chromatography: II. Rate theory and the measurement of biological binding kinetics. Journal of Chromatography A, 355 . pp. 13-27. ISSN 0021-9673. http://resolver.caltech.edu/CaltechAUTHORS:20180823-083642906

This list was generated on Tue Sep 17 23:15:10 2019 PDT.