CaltechAUTHORS
  A Caltech Library Service

Items where Person is "Deshaies-R-J"

Up a level
Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Date | Item Type | First Author | No Grouping
Number of items: 119.

Yang, Seung-Joo and Jeon, Seung-Je and Van Nguyen, Thang et al. (2020) Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity. Biochimica et Biophysica Acta, 1867 (8). Art. No. 118729. ISSN 0167-4889. https://resolver.caltech.edu/CaltechAUTHORS:20200423-133323910

Reichermeier, Kurt M. and Straube, Ronny and Reitsma, Justin M. et al. (2020) PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. Molecular Cell, 77 (5). pp. 1092-1106. ISSN 1097-2765. https://resolver.caltech.edu/CaltechAUTHORS:20200122-081543072

Blythe, Emily E. and Gates, Stephanie N. and Deshaies, Raymond J. et al. (2019) Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing. Structure, 27 (12). pp. 1820-1829. ISSN 0969-2126. PMCID PMC6929323. https://resolver.caltech.edu/CaltechAUTHORS:20191014-113833407

Yu, Helen H. and Reitsma, Justin M. and Sweredoski, Mike J. et al. (2019) Single subunit degradation of WIZ, a lenalidomide- and pomalidomide dependent substrate of E3 ubiquitin ligase CRL4^(CRBN). . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20190402-104546411

Li, Jing and Zhang, Yaru and Da Silva Sil Dos Santos, Bruno et al. (2018) Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11. Cell Chemical Biology, 25 (11). pp. 1350-1358. ISSN 2451-9456. PMCID PMC6309308. https://resolver.caltech.edu/CaltechAUTHORS:20180823-134532623

Verma, Rati and Reichermeier, Kurt M. and Burroughs, A. Maxwell et al. (2018) Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes. Nature, 557 (7705). pp. 446-451. ISSN 0028-0836. PMCID PMC6226276. https://resolver.caltech.edu/CaltechAUTHORS:20180110-115638809

Lobanova, Ekaterina S. and Finkelstein, Stella and Li, Jing et al. (2018) Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration. Nature Communications, 9 . Art. No. 1738. ISSN 2041-1723. PMCID PMC5928105. https://resolver.caltech.edu/CaltechAUTHORS:20180503-101314227

Liu, Xing and Reitsma, Justin M. and Mamrosh, Jennifer L. et al. (2018) Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. Molecular Cell, 69 (5). pp. 773-786. ISSN 1097-2765. PMCID PMC5836512. https://resolver.caltech.edu/CaltechAUTHORS:20180301-131842787

Blythe, E. E. and Martin, A. and Deshaies, R. J. (2017) Characterization of p97 mutations causing multisystem proteinopathy support a gain-of-function model for pathology. Molecular Biology of the Cell, 28 (26). Art. No. M125. ISSN 1059-1524. https://resolver.caltech.edu/CaltechAUTHORS:20180321-142839561

Skrott, Zdenek and Li, Jing and Deshaies, Raymond J. (2017) Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature, 552 (7684). pp. 194-199. ISSN 0028-0836. PMCID PMC5730499. https://resolver.caltech.edu/CaltechAUTHORS:20171102-125033790

Nakasone, Mark A. and Lewis, Timothy A. and Walker, Olivier et al. (2017) Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway. Structure, 25 (12). pp. 1839-1855. ISSN 0969-2126. https://resolver.caltech.edu/CaltechAUTHORS:20171128-081216731

Reitsma, Justin M. and Liu, Xing and Reichermeier, Kurt M. et al. (2017) Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. Cell, 171 (6). pp. 1326-1339. ISSN 0092-8674. PMCID PMC5711595. https://resolver.caltech.edu/CaltechAUTHORS:20171102-102235105

Lauinger, Linda and Li, Jing and Shostak, Anton et al. (2017) Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nature Chemical Biology, 13 (7). pp. 709-714. ISSN 1552-4450. https://resolver.caltech.edu/CaltechAUTHORS:20170306-094038307

Blythe, Emily E. and Olson, Kristine C. and Chau, Vincent et al. (2017) Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy. Proceedings of the National Academy of Sciences of the United States of America, 114 (22). E4380-E4388. ISSN 0027-8424. PMCID PMC5465906. https://resolver.caltech.edu/CaltechAUTHORS:20170516-101734172

Li, Jing and Yakushi, Tanya and Parlati, Francesco et al. (2017) Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nature Chemical Biology, 13 (5). pp. 486-493. ISSN 1552-4450. https://resolver.caltech.edu/CaltechAUTHORS:20170106-105003568

Nguyen, Van Thang and Li, Jing and Lu, Chin-Chun (Jean) et al. (2017) p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proceedings of the National Academy of Sciences of the United States of America, 114 (14). pp. 3565-3571. ISSN 0027-8424. PMCID PMC5389304. https://resolver.caltech.edu/CaltechAUTHORS:20170320-154317309

Perez, Christian and Li, Jing and Parlati, Francesco et al. (2017) Discovery of an Inhibitor of the Proteasome Subunit Rpn11. Journal of Medicinal Chemistry, 60 (4). pp. 1343-1361. ISSN 0022-2623. https://resolver.caltech.edu/CaltechAUTHORS:20170324-090339100

Reiterer, Veronika and Figueras-Puig, Cristina and Le Guerroue, Francois et al. (2017) The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCF^(FBXW7) function. EMBO Journal, 36 (3). pp. 260-273. ISSN 0261-4189. PMCID PMC5286380. https://resolver.caltech.edu/CaltechAUTHORS:20170104-144844772

Vangala, Janakiram R. and Sotzny, Franziska and Krüger, Elke et al. (2016) Nrf1 can be processed and activated in a proteasome-independent manner. Current Biology, 26 (18). R834-R835. ISSN 0960-9822. PMCID PMC6156719. https://resolver.caltech.edu/CaltechAUTHORS:20161003-085621178

Sung, Min-Kyung and Reitsma, Justin M. and Sweredoski, Michael J. et al. (2016) Ribosomal proteins produced in excess are degraded by the ubiquitin-proteasome system. Molecular Biology of the Cell, 27 (17). pp. 2642-2652. ISSN 1059-1524. PMCID PMC5007085. https://resolver.caltech.edu/CaltechAUTHORS:20160708-082549598

Xue, Liang and Blythe, Emily E. and Freiberger, Elyse C. et al. (2016) Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor. Molecular and Cellular Proteomics, 15 (9). pp. 2970-2986. ISSN 1535-9476. PMCID PMC5013311. https://resolver.caltech.edu/CaltechAUTHORS:20160718-111759001

Kleiger, Gary and Deshaies, Raymond (2016) Tag Team Ubiquitin Ligases. Cell, 166 (5). pp. 1080-1081. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20160829-080930690

Sung, Min-Kyung and Porras-Yakushi, Tanya R. and Reitsma, Justin M. et al. (2016) A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins. eLife, 5 . Art. No. e19105. ISSN 2050-084X. PMCID PMC5026473. https://resolver.caltech.edu/CaltechAUTHORS:20160901-122707403

Mosadeghi, Ruzbeh and Reichermeier, Kurt M. and Winkler, Martin et al. (2016) Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle. eLife, 5 . Art. No. e12102. ISSN 2050-084X. PMCID PMC4878873. https://resolver.caltech.edu/CaltechAUTHORS:20160405-075712117

Nguyen, T. Van and Lee, J. Eugene and Sweredoski, Michael J. et al. (2016) Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Molecular Cell, 61 (6). pp. 809-820. ISSN 1097-2765. PMCID PMC4889030. https://resolver.caltech.edu/CaltechAUTHORS:20160321-131029451

Banerjee, Sooiay and Bartesaghi, Alberto and Merk, Alan et al. (2016) 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science, 351 (6275). pp. 871-875. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20160208-092709831

Alverez, Celeste and Bulfer, Stacie L. and Chakrasali, Ramappa et al. (2016) Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. ACS Medicinal Chemistry Letters, 7 (2). pp. 182-187. ISSN 1948-5875. https://resolver.caltech.edu/CaltechAUTHORS:20160315-125347072

Deshaies, Raymond J. (2015) Protein degradation: Prime time for PROTACs. Nature Chemical Biology, 11 (9). pp. 634-635. ISSN 1552-4450. https://resolver.caltech.edu/CaltechAUTHORS:20150911-085528272

Deshaies, Raymond and Li, Jing (2015) Exploiting protein homeostasis for cancer therapy. In: 250th American Chemical Society National Meeting & Exposition, August 16-20, 2015, Boston, MA. https://resolver.caltech.edu/CaltechAUTHORS:20151021-133303640

Pulvino, Mary and Chen, Luojing and Oleksyn, David et al. (2015) Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget, 6 (17). pp. 14796-14813. ISSN 1949-2553. PMCID PMC4558116. https://resolver.caltech.edu/CaltechAUTHORS:20150706-111955387

Fang, Nancy N. and Chan, Gerard T. and Zhu, Mang et al. (2014) Rsp5/​Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. Nature Cell Biology, 16 (12). pp. 1227-1237. ISSN 1465-7392. PMCID PMC5224936. https://resolver.caltech.edu/CaltechAUTHORS:20140915-125611389

Deshaies, Raymond J. (2014) Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy. BMC Biology, 12 . Art. No. 94. ISSN 1741-7007. PMCID PMC4226866. https://resolver.caltech.edu/CaltechAUTHORS:20150122-083936041

Deshaies, Raymond J. (2014) Corralling a protein-degradation regulator. Nature, 512 (7513). pp. 145-146. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20140903-135522551

Chou, Tsui-Fen and Bulfer, Stacie L. and Weihl, Conrad C. et al. (2014) Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase domains. Journal of Molecular Biology, 426 (15). pp. 2886-2899. ISSN 0022-2836. PMCID PMC4102644. https://resolver.caltech.edu/CaltechAUTHORS:20140609-114312310

Deshaies, Raymond J. (2014) Structural biology: Corralling a protein-degradation regulator. Nature . ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20140728-083757319

Chan, Nickie C. and den Besten, Willem and Sweredoski, Michael J. et al. (2014) Degradation of the Deubiquitinating Enzyme USP33 is Mediated by p97 and the Ubiquitin Ligase HERC2. Journal of Biological Chemistry, 289 (28). pp. 19789-19798. ISSN 0021-9258. PMCID PMC4094088. https://resolver.caltech.edu/CaltechAUTHORS:20140604-082523933

Deshaies, Raymond and Chou, Tsui-Fen and Li, Jing et al. (2014) Exploiting protein homeostasis for cancer therapy. FASEB Journal, 28 (1). 472.2. ISSN 0892-6638. https://resolver.caltech.edu/CaltechAUTHORS:20150205-100227097

Honarpour, Narimon and Rose, Christopher M. and Brumbaugh, Justin et al. (2014) F-box Protein FBXL16 Binds PP2A-B55α and Regulates Differentiation of Embryonic Stem Cells along the FLK1+ Lineage. Molecular and Cellular Proteomics, 13 (3). pp. 780-791. ISSN 1535-9476. PMCID PMC3945908. https://resolver.caltech.edu/CaltechAUTHORS:20140417-141503413

Radhakrishnan, Senthil K. and den Besten, Willem and Deshaies, Raymond J. (2014) p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. eLife, 3 . Art. No. e01856 . ISSN 2050-084X. PMCID PMC3896944. https://resolver.caltech.edu/CaltechAUTHORS:20140225-085700599

Kolawa, Natalie and Sweredoski, Michael J. and Graham, Robert L. J. et al. (2013) Perturbations to the Ubiquitin Conjugate Proteome in Yeast Δubx Mutants Identify Ubx2 as a Regulator of Membrane Lipid Composition. Molecular and Cellular Proteomics, 12 (10). pp. 2791-2803. ISSN 1535-9476. PMCID PMC3790291. https://resolver.caltech.edu/CaltechAUTHORS:20140306-101045851

Kurimchak, Alison and Haines, Dale S. and Garriga, Judit et al. (2013) Activation of p107 by Fibroblast Growth Factor, Which Is Essential for Chondrocyte Cell Cycle Exit, Is Mediated by the Protein Phosphatase 2A/B55α Holoenzyme. Molecular and Cellular Biology, 33 (16). pp. 3330-3342. ISSN 0270-7306. PMCID PMC3753905. https://resolver.caltech.edu/CaltechAUTHORS:20130904-105931353

Shi, Yihui and Liu, Xiaohe and Calaoagan, Joy et al. (2013) Development of functional assays for p97/VCP inhibition. Cancer Research, 73 (8). Art. No. 2146. ISSN 0008-5472. https://resolver.caltech.edu/CaltechAUTHORS:20140325-082556135

Pierce, Nathan W. and Lee, J. Eugene and Liu, Xing et al. (2013) Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins. Cell, 153 (1). pp. 206-215. ISSN 0092-8674. PMCID PMC3656483. https://resolver.caltech.edu/CaltechAUTHORS:20130517-081333288

Chou, Tsui-Fen and Li, Kelin and Frankowski, Kevin J. et al. (2013) Structure–Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase. ChemMedChem, 8 (2). pp. 297-312. ISSN 1860-7179. PMCID PMC3662613. https://resolver.caltech.edu/CaltechAUTHORS:20130301-075535357

Verma, Rati and Oania, Robert S. and Kolawa, Natalie J. et al. (2013) Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome. eLife, 2013 (2). Art. No. e00308. ISSN 2050-084X. PMCID PMC3552423. https://resolver.caltech.edu/CaltechAUTHORS:20130123-093059603

Emberley, Ethan D. and Mosadeghi, Ruzbeh and Deshaies, Raymond J. (2012) Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism. Journal of Biological Chemistry, 287 (35). pp. 29679-29689. ISSN 0021-9258. PMCID PMC3436198. https://resolver.caltech.edu/CaltechAUTHORS:20121009-110244928

Oh, Younghoon and Chang, Kuang-Jung and Orlean, Peter et al. (2012) Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast. Molecular Biology of the Cell, 23 (13). pp. 2445-2456. ISSN 1059-1524. PMCID PMC3386209. https://resolver.caltech.edu/CaltechAUTHORS:20120807-123207702

Haines, Dale S. and Lee, J. Eugene and Beauparlant, Stephen L. et al. (2012) Protein Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the Complex in Modulating ERGIC-53 Trafficking. Molecular and Cellular Proteomics, 11 (6). Art. No. M111.016444. ISSN 1535-9476. PMCID PMC3433925. https://resolver.caltech.edu/CaltechAUTHORS:20120803-152029217

den Besten, Willem and Verma, Rati and Kleiger, Gary et al. (2012) NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nature Structural & Molecular Biology, 19 (5). pp. 511-516. ISSN 1545-9985. PMCID PMC3348432. https://resolver.caltech.edu/CaltechAUTHORS:20120601-100510892

Sohn, Chang Ho and Agnew, Heather D. and Lee, J. Eugene et al. (2012) Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions. Analytical Chemistry, 84 (6). pp. 2662-2669. ISSN 0003-2700. PMCID PMC3310289. https://resolver.caltech.edu/CaltechAUTHORS:20120417-113310153

Sohn, Chang Ho and Lee, J. Eugene and Sweredoski, Michael J. et al. (2012) Click Chemistry Facilitates Formation of Reporter Ions and Simplified Synthesis of Amine-Reactive Multiplexed Isobaric Tags for Protein Quantification. Journal of the American Chemical Society, 134 (5). pp. 2672-2680. ISSN 0002-7863. PMCID PMC3668889. https://resolver.caltech.edu/CaltechAUTHORS:20120202-074303275

Chou, Tsui-Fen and Deshaies, Raymond J. (2011) Development of p97 AAA ATPase inhibitors. Autophagy, 7 (9). pp. 1091-1092. ISSN 1554-8627. PMCID PMC3210319. https://resolver.caltech.edu/CaltechAUTHORS:20110930-072701050

Rabut, Gwenaël and Le Dez, Gaëlle and Verma, Rati et al. (2011) The TFIIH Subunit Tfb3 Regulates Cullin Neddylation. Molecular Cell, 43 (3). pp. 488-495. ISSN 1097-2765. PMCID PMC3186349. https://resolver.caltech.edu/CaltechAUTHORS:20110830-133501205

Gomez, Tara A. and Kolawa, Natalie and Gee, Marvin et al. (2011) Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1. BMC Biology, 9 . Art. No. 33. ISSN 1741-7007. PMCID PMC3126750. https://resolver.caltech.edu/CaltechAUTHORS:20110705-093954428

Chou, Tsui-Fen and Deshaies, Raymond J. (2011) Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System. Journal of Biological Chemistry, 286 (19). pp. 16546-16554. ISSN 0021-9258. PMCID PMC3089497. https://resolver.caltech.edu/CaltechAUTHORS:20110606-105141967

Lee, J. Eugene and Sweredoski, Michael J. and Graham, Robert L. J. et al. (2011) The steady-state repertoire of human SCF Ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. Molecular and Cellular Proteomics, 10 (5). Art. No. M110.006460. ISSN 1535-9476. PMCID PMC3098594. https://resolver.caltech.edu/CaltechAUTHORS:20110526-100158794

Saha, Anjanabha and Lewis, Steven and Kleiger, Gary et al. (2011) Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate. Molecular Cell, 42 (1). pp. 75-83. ISSN 1097-2765. PMCID PMC3091889. https://resolver.caltech.edu/CaltechAUTHORS:20110502-103732644

Chou, Tsui-Fen and Brown, Steve J. and Minond, Dmitriy et al. (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proceedings of the National Academy of Sciences of the United States of America, 108 (12). pp. 4834-4839. ISSN 0027-8424. PMCID PMC3064330. https://resolver.caltech.edu/CaltechAUTHORS:20110414-085357247

Verma, Rati and Oania, Robert and Fang, Ruihua et al. (2011) Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II. Molecular Cell, 41 (1). pp. 82-92. ISSN 1097-2765. PMCID PMC3063307. https://resolver.caltech.edu/CaltechAUTHORS:20110202-104707165

Chou, T. and Deshaies, R. (2010) Development of p97 inhibitors as potential anti-cancer therapeutics. In: International Chemical Congress of Pacific Basin Societies (Pacifichem 2010), December 15-20, 2010, Honolulu, HI. https://resolver.caltech.edu/CaltechAUTHORS:20120816-071903890

Tyrrell, An and Flick, Karin and Kleiger, Gary et al. (2010) Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins. Proceedings of the National Academy of Sciences of the United States of America, 107 (46). pp. 19796-19801. ISSN 0027-8424. PMCID PMC2993400. https://resolver.caltech.edu/CaltechAUTHORS:20141120-133841734

Collins, Galen A. and Gomez, Tara Adele and Deshaies, Raymond J. et al. (2010) Combined chemical and genetic approach to inhibit proteolysis by the proteasome. Yeast, 27 (11). pp. 965-974. ISSN 0749-503X. PMCID PMC3566228. https://resolver.caltech.edu/CaltechAUTHORS:20101210-081023629

Aghajan, Mariam and Jonai, Nao and Flick, Karin et al. (2010) Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nature Biotechnology, 28 (7). pp. 738-742. ISSN 1087-0156. PMCID PMC2902569. https://resolver.caltech.edu/CaltechAUTHORS:20100802-150048893

Radhakrishnan, Senthil K. and Lee, Candy S. and Young, Patrick et al. (2010) Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells. Molecular Cell, 38 (1). pp. 17-28. ISSN 1097-2765. PMCID PMC2874685. https://resolver.caltech.edu/CaltechAUTHORS:20100610-122051580

Kleiger, Gary and Hao, Bing and Mohl, Dane A. et al. (2009) The Acidic Tail of the Cdc34 Ubiquitin-conjugating Enzyme Functions in Both Binding to and Catalysis with Ubiquitin Ligase SCFC^(dc4*). Journal of Biological Chemistry, 284 (52). pp. 36012-36023. ISSN 0021-9258. PMCID PMC2794717. https://resolver.caltech.edu/CaltechAUTHORS:20100121-133925591

Pierce, Nathan W. and Kleiger, Gary and Shan, Shu-ou et al. (2009) Detection of sequential polyubiquitylation on a millisecond timescale. Nature, 462 (7273 ). pp. 615-620. ISSN 0028-0836. PMCID PMC2791906. https://resolver.caltech.edu/CaltechAUTHORS:20091221-110503492

Kleiger, Gary and Saha, Anjanabha and Lewis, Steven et al. (2009) Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates. Cell, 139 (5). pp. 957-968. ISSN 0092-8674. PMCID PMC2804849. https://resolver.caltech.edu/CaltechAUTHORS:20091215-154909824

Collins, Galen A. and Lipford, J. Russell and Deshaies, Raymond J. et al. (2009) Gal4 turnover and transcription activation. Nature, 461 (7265). E7-E8. ISSN 0028-0836. PMCID PMC3072683. https://resolver.caltech.edu/CaltechAUTHORS:20091022-111502275

Deshaies, Raymond J. and Joazeiro, Claudio A. P. (2009) RING domain E3 ubiquitin ligases. Annual Review of Biochemistry, 78 . pp. 399-434. ISSN 0066-4154. https://resolver.caltech.edu/CaltechAUTHORS:20090814-114618979

Deshaies, Raymond J. (2009) Drug discovery: fresh target for cancer therapy. Nature, 458 (7239). pp. 709-710. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20090506-152750120

Oh, Young Mi and Kwon, Young Eun and Kim, Joo Mi et al. (2009) Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nature Cell Biology, 11 (3). pp. 295-302. ISSN 1465-7392. https://resolver.caltech.edu/CaltechAUTHORS:20090529-100421943

Mohl, Dane A. and Huddleston, Michael J. and Collingwood, Therese S. et al. (2009) Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis. Journal of Cell Biology, 184 (4). pp. 527-539. ISSN 0021-9525. PMCID PMC2654127. https://resolver.caltech.edu/CaltechAUTHORS:20090410-083623634

Machida, Keigo and Tsukamoto, Hidekazu and Mkrtchyan, Hasmik et al. (2009) Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proceedings of the National Academy of Sciences of the United States of America, 106 (5). pp. 1548-1553. ISSN 0027-8424. PMCID PMC2635765. https://resolver.caltech.edu/CaltechAUTHORS:MACpnas09

Rodriguez-Gonzalez, A. and Cyrus, K. and Salcius, M. et al. (2008) Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. Oncogene, 27 (57). pp. 7201-7211. ISSN 0950-9232. PMCID PMC5573236. https://resolver.caltech.edu/CaltechAUTHORS:RODo08

Saha, Anjanabha and Deshaies, Raymond J. (2008) Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Molecular Cell, 32 (1). pp. 21-31. ISSN 1097-2765. PMCID PMC2644375. https://resolver.caltech.edu/CaltechAUTHORS:SAHmc08

Sakamoto, K. and Rodriguez-Gonzalez, A. and Cyrus, K. et al. (2008) Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. European Journal of Cancer Supplements, 6 (12). p. 16. ISSN 1359-6349. https://resolver.caltech.edu/CaltechAUTHORS:SAKejcs08

Goh, Amanda M. and Walters, Kylie J. and Elsasser, Suzanne et al. (2008) Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochemistry, 9 . Art. No. 4. ISSN 1471-2091. PMCID PMC2267792. https://resolver.caltech.edu/CaltechAUTHORS:GOHbmcb08

Mayor, Thibault and Graumann, Johannes and Bryan, Jennnifer et al. (2007) Quantitative Profiling of Ubiquitylated Proteins Reveals Proteasome Substrates and the Substrate Repertoire Influenced by the Rpn10 Receptor Pathway. Molecular and Cellular Proteomics, 6 (11). pp. 1885-1895. ISSN 1535-9476. https://resolver.caltech.edu/CaltechAUTHORS:MAYmcp07

Ghaboosi, Nazli and Deshaies, Raymond J. (2007) A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome. Molecular Biology of the Cell, 18 (5). pp. 1953-1963. ISSN 1059-1524. PMCID PMC1855034. https://resolver.caltech.edu/CaltechAUTHORS:GHAmbc07

Sharon, Michal and Taverner, Thomas and Ambroggio, Xavier I. et al. (2006) Structural Organization of the 19S Proteasome Lid: Insights from MS of Intact Complexes. PLoS Biology, 4 (8). e267. ISSN 1544-9173. PMCID PMC1523230. https://resolver.caltech.edu/CaltechAUTHORS:SHAplosbio06

Cope, Gregory A. and Deshaies, Raymond J. (2006) Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels. BMC Biochemistry, 7 . Art. No. 1. ISSN 1471-2091. PMCID PMC1360668. https://resolver.caltech.edu/CaltechAUTHORS:COPbmcbc06

Lipford, J. Russell and Smith, Geoffrey T. and Chi, Yong et al. (2005) A putative stimulatory role for activator turnover in gene expression. Nature, 438 (7064). pp. 113-116. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150325-103747797

Mah, Angie S. and Elia, Andrew E. H. and Devgan, Geeta et al. (2005) Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochemistry, 6 . Art. No. 22. ISSN 1471-2091. PMCID PMC1277818. https://resolver.caltech.edu/CaltechAUTHORS:MAHbmcb05

Mayor, Thibault and Lipford, J. Russell and Graumann, Johannes et al. (2005) Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets. Molecular and Cellular Proteomics, 4 (6). pp. 741-751. ISSN 1535-9476. https://resolver.caltech.edu/CaltechAUTHORS:MAYmcp05

Petroski, Matthew D. and Deshaies, Raymond J. (2005) Function and regulation of Cullin-RING ubiquitin ligases. Nature Reviews. Molecular Cell Biology, 6 (1). pp. 9-20. ISSN 1471-0072. https://resolver.caltech.edu/CaltechAUTHORS:20150318-153239947

Deshaies, Raymond (2004) Varshavsky's Contributions. Science, 306 (5700). pp. 1290-1292. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141119-103538397

Verma, Rati and Peters, Noel R. and D'Onofrio, Mariapina et al. (2004) Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain. Science, 306 (5693). pp. 117-120. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141119-110723281

Azzam, Ramzi and Chen, Susan L. and Shou, Wenying et al. (2004) Phosphorylation by Cyclin B-Cdk Underlies Release of Mitotic Exit Activator Cdc14 from the Nucleolus. Science, 305 (5683). pp. 516-519. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141118-095256128

Schneekloth, John S., Jr. and Fonseca, Fabiana N. and Koldobskiy, Michael et al. (2004) Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation. Journal of the American Chemical Society, 126 (12). pp. 3748-3754. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20170419-145525640

Graumann, Johannes and Dunipace, Leslie A. and Seol, Jae Hong et al. (2004) Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast. Molecular and Cellular Proteomics, 3 (3). pp. 226-237. ISSN 1535-9476. https://resolver.caltech.edu/CaltechAUTHORS:GRAmcp04

Wertz, Ingrid E. and O’Rourke, Karen M. and Zhang, Zemin et al. (2004) Human De-Etiolated-1 Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase. Science, 303 (5662). pp. 1371-1374. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141125-123907609

Ambroggio, Xavier I. and Rees, Douglas C. and Deshaies, Raymond J. (2004) JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome. PLoS Biology, 2 (1). pp. 113-119. ISSN 1544-9173. PMCID PMC300881. https://resolver.caltech.edu/CaltechAUTHORS:AMBpb04

Sakamoto, Kathleen M. and Kim, Kyung B. and Verma, Rati et al. (2003) Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation. Molecular and Cellular Proteomics, 2 (12). pp. 1350-1358. ISSN 1535-9476. https://resolver.caltech.edu/CaltechAUTHORS:SAKmcp03

Lipford, J. Russell and Deshaies, Raymond J. (2003) Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nature Cell Biology, 5 (10). pp. 845-850. ISSN 1465-7392. https://resolver.caltech.edu/CaltechAUTHORS:20150330-125857288

Cope, Gregory A. and Suh, Greg S. and Aravind, L. et al. (2002) Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1. Science, 298 (5593). pp. 608-611. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141118-152419645

Verma, Rati and Aravind, L. and Oania, Robert et al. (2002) Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome. Science, 298 (5593). pp. 611-615. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141118-131459067

Shou, Wenying and Azzam, Ramzi and Chen, Susan L. et al. (2002) Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex. BMC Molecular Biology, 3 (3). pp. 1-14. ISSN 1471-2199. PMCID PMC113746. https://resolver.caltech.edu/CaltechAUTHORS:SHObmcmb02

Shou, Wenying and Deshaies, Raymond J. (2002) Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae. BMC Genetics, 3 . Art. No. 4. ISSN 1471-2156. PMCID PMC102333. https://resolver.caltech.edu/CaltechAUTHORS:SHObmcg02

Chen, Susan Loughery and Huddleston, Michael J. and Shou, Wenying et al. (2002) Mass Spectrometry-based Methods for Phosphorylation Site Mapping of Hyperphosphorylated Proteins Applied to Net1, a Regulator of Exit from Mitosis in Yeast. Molecular and Cellular Proteomics, 1 (3). pp. 186-196. ISSN 1535-9476. https://resolver.caltech.edu/CaltechAUTHORS:LOUmcp02

Deshaies, Raymond J. and Seol, Jae Hong and McDonald, W. Hayes et al. (2002) Charting the protein complexome in yeast by mass spectrometry. Molecular and Cellular Proteomics, 1 (1). pp. 3-10. ISSN 1535-9476. https://resolver.caltech.edu/CaltechAUTHORS:DESmcp02

Wu, Guangyu and Lyapina, Svetlana and Das, Indranil et al. (2001) SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation. Molecular and Cellular Biology, 21 (21). pp. 7403-7415. ISSN 0270-7306. PMCID PMC99913. https://resolver.caltech.edu/CaltechAUTHORS:WUGmcb01

Zhou, Chunshui and Seibert, Volker and Geyer, Rory et al. (2001) The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. BMC Biochemistry, 2 (7). pp. 1-11. ISSN 1471-2091. PMCID PMC37391. https://resolver.caltech.edu/CaltechAUTHORS:ZHObmcb01

Sakamoto, Kathleen M. and Kim, Kyung B. and Kumagai, Akiko et al. (2001) Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proceedings of the National Academy of Sciences of the United States of America, 98 (15). pp. 8554-8559. ISSN 0027-8424. PMCID PMC37474. https://resolver.caltech.edu/CaltechAUTHORS:SAKpnas01

Mah, Angie S. and Jang, Joanne and Deshaies, Raymond J. (2001) Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proceedings of the National Academy of Sciences of the United States of America, 98 (13). pp. 7325-7330. ISSN 0027-8424. PMCID PMC34667. https://resolver.caltech.edu/CaltechAUTHORS:MAHpnas01

Traverso, Edwin E. and Baskerville, Christopher and Liu, Yan et al. (2001) Characterization of the Net1 cell cycle-dependent regulator of the Cdc14 phosphatase from budding yeast. Journal of Biological Chemistry, 276 (24). pp. 21924-21931. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:TRAjbc01

Schwechheimer, Claus and Serino, Giovanna and Callis, Judy et al. (2001) Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF^(TIR1) in Mediating Auxin Response. Science, 292 (5520). pp. 1379-1382. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141118-111944453

Lyapina, Svetlana and Cope, Gregory and Shevchenko, Anna et al. (2001) Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome. Science, 292 (5520). pp. 1382-1385. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141118-095512539

Galan, Jean-Marc and Wiederkehr, Andreas and Seol, Jae Hong et al. (2001) Skp1p and the F-Box Protein Rcy1p Form a Non-SCF Complex Involved in Recycling of the SNARE Snc1p in Yeast. Molecular and Cellular Biology, 21 (9). pp. 3105-3117. ISSN 0270-7306. PMCID PMC86938. https://resolver.caltech.edu/CaltechAUTHORS:GAImcb01

Seol, Jae Hong and Shevchenko, Anna and Shevchenko, Andrej et al. (2001) Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly. Nature Cell Biology, 3 (4). pp. 384-391. ISSN 1465-7392. https://resolver.caltech.edu/CaltechAUTHORS:20150513-100150441

Annan, Roland S. and Huddleston, Michael J. and Verma, Rati et al. (2001) A Multidimensional Electrospray MS-Based Approach to Phosphopeptide Mapping. Analytical Chemistry, 73 (3). pp. 393-404. ISSN 0003-2700. https://resolver.caltech.edu/CaltechAUTHORS:20160803-144337603

Verma, Rati and Chen, Stephen and Feldman, Renny et al. (2000) Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes. Molecular Biology of the Cell, 11 (10). pp. 3425-3439. ISSN 1059-1524. PMCID PMC15004. https://resolver.caltech.edu/CaltechAUTHORS:VERmbc00

Reynard, Gregory J. and Reynolds, William and Verma, Rati et al. (2000) Cks1 Is Required for G1 Cyclin-Cyclin-Dependent Kinase Activity in Budding Yeast. Molecular and Cellular Biology, 20 (16). pp. 5858-5864. ISSN 0270-7306. PMCID PMC86063. https://resolver.caltech.edu/CaltechAUTHORS:REYmcb00

Deshaies, Raymond J. and Meyerowitz, Elliot M. (2000) COP1 patrols the night beat. Nature Cell Biology, 2 (6). E102-E104. ISSN 1465-7392. https://resolver.caltech.edu/CaltechAUTHORS:20150408-152200145

Deshaies, R. J. (1999) SCF and Cullin/RING H2-based ubiquitin ligases. Annual Review of Cell and Developmental Biology, 15 . pp. 435-467. ISSN 1081-0706. https://resolver.caltech.edu/CaltechAUTHORS:20120712-093451798

Lyapina, Svetlana A. and Correll, Craig C. and Kipreos, Edward T. et al. (1998) Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. Proceedings of the National Academy of Sciences of the United States of America, 95 (13). pp. 7451-7456. ISSN 0027-8424. PMCID PMC22647. https://resolver.caltech.edu/CaltechAUTHORS:LYApnas98

Verma, R. and Annan, R. S. and Huddleston, M. J. et al. (1997) Phosphorylation of Sic1p by G_1 Cdk Required for Its Degradation and Entry into S Phase. Science, 278 (5337). pp. 455-460. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141203-080007204

Verma, Rati and Feldman, R. M. Renny and Deshaies, Raymond J. (1997) SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Molecular Biology of the Cell, 8 (8). pp. 1427-1437. ISSN 1059-1524. PMCID PMC276167. https://resolver.caltech.edu/CaltechAUTHORS:VERmbc97

King, Randall W. and Deshaies, Raymond J. and Peters, Jan-Michael et al. (1996) How Proteolysis Drives the Cell Cycle. Science, 274 (5293). pp. 1652-1659. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20140722-085457381

Banerjee, Amit and Deshaies, Raymond J. and Chau, Vincent (1995) Characterization of a Dominant Negative Mutant of the Cell Cycle Ubiquitin-conjugating Enzyme Cdc34. Journal of Biological Chemistry, 270 (44). pp. 26209-26215. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:BANjbc95

This list was generated on Thu Jul 2 13:02:56 2020 PDT.