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Number of items: 83.


Hay, Bruce A. and Oberhofer, Georg and Guo, Ming (2020) Engineering the Composition and Fate of Wild Populations with Gene Drive. Annual Review of Entomology . ISSN 0066-4170. (In Press)

Oberhofer, Georg and Ivy, Tobin and Hay, Bruce A. (2020) 2-Locus ​ Cleave and Rescue ​ selfish elements harness a recombination rate-dependent generational clock for self limiting gene drive. . (Unpublished)

Kandul, Nikolay P. and Liu, Junru and Hsu, Alexander D. et al. (2020) A drug-inducible sex-separation technique for insects. Nature Communications, 11 . Art. No. 2106. ISSN 2041-1723. PMCID PMC7193620.

Oberhofer, Georg and Ivy, Tobin and Hay, Bruce A. (2020) Gene drive and resilience through renewal with next generation Cleave and Rescue selfish genetic elements. Proceedings of the National Academy of Sciences of the United States of America, 117 (16). pp. 9013-9021. ISSN 0027-8424. PMCID PMC7183144.


Oberhofer, Georg and Ivy, Tobin and Hay, Bruce A. (2019) Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive. Proceedings of the National Academy of Sciences of the United States of America, 116 (13). pp. 6250-6259. ISSN 0027-8424. PMCID PMC6442612.


Oberhofer, Georg and Ivy, Tobin and Hay, Bruce A. (2018) Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs. Proceedings of the National Academy of Sciences of the United States of America, 115 (40). E9343-E9352. ISSN 0027-8424. PMCID PMC6176634.

Buchman, Anna B. and Ivy, Tobin and Marshall, John M. et al. (2018) Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila. ACS Synthetic Biology, 7 (5). pp. 1359-1370. ISSN 2161-5063.

Hay, Bruce A. and Li, Juan and Guo, Ming (2018) Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation. Theriogenology, 112 . pp. 63-74. ISSN 0093-691X.


Adelman, Zach and Hay, Bruce A. (2017) Rules of the road for insect gene drive research and testing. Nature Biotechnology, 35 (8). pp. 716-718. ISSN 1087-0156. PMCID PMC5831321.

Kandul, Nikolay and Guo, Ming and Hay, Bruce A. (2017) A positive readout single transcript reporter for site-specific mRNA cleavage. PeerJ, 5 . Art. No. e3602. ISSN 2167-8359. PMCID PMC5522606.

Zhang, Ting and Mishra, Prashant and Hay, Bruce A. et al. (2017) Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. eLife, 6 . Art. No. e17834. ISSN 2050-084X. PMCID PMC5360448.


Kandul, Nikolay P. and Zhang, Ting and Hay, Bruce A. et al. (2016) Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila. Nature Communications, 7 . Art. No. 13100. ISSN 2041-1723. PMCID PMC5114534.

Choi, Harry M. T. and Calvert, Colby R. and Husain, Naeem et al. (2016) Mapping a multiplexed zoo of mRNA expression. Development, 143 (19). pp. 3632-3637. ISSN 0950-1991. PMCID PMC5087610.


Ferree, Patrick M. and Fang, Christopher and Mastrodimos, Mariah et al. (2015) Identification of Genes Uniquely Expressed in the Germ Line Tissues of the Jewel Wasp Nasonia vitripennis. G3, 5 (12). pp. 2647-2653. ISSN 2160-1836. PMCID PMC4683638.

Li, Juan and Olvera, Alejandra I. and Akbari, Omar S. et al. (2015) Vectored antibody gene delivery mediates long-term contraception. Current Biology, 25 (19). R820-R822. ISSN 0960-9822.


Akbari, Omar S. and Chen, Chun-Hong and Marshall, John M. et al. (2014) Novel Synthetic Medea Selfish Genetic Elements Drive Population Replacement in Drosophila; a Theoretical Exploration of Medea-Dependent Population Suppression. ACS Synthetic Biology, 3 (12). pp. 915-928. ISSN 2161-5063. PMCID PMC3742681.

Marshall, John M. and Hay, Bruce A. (2014) Medusa: A Novel Gene Drive System for Confined Suppression of Insect Populations. PLoS ONE, 9 (7). e102694. ISSN 1932-6203. PMCID PMC4108329.

Akbari, Omar S. and Papathanos, Philippos A. and Sandler, Jeremy E. et al. (2014) Identification of germline transcriptional regulatory elements in Aedes aegypti. Scientific Reports, 4 . Art. No. 3954. ISSN 2045-2322. PMCID PMC3912481.


Akbari, Omar and Marshall, John and Antoshechkin, Igor et al. (2013) Engineering synthetic medea-based and threshold-dependent underdominance-based gene drive systems in mosquitos. Pathogens and Global Health, 107 (8). p. 442. ISSN 2047-7724.

Marshall, John and White, Michael and Beier, John et al. (2013) Mathematical insights into novel vector control strategies: from outdoor control to confineable transgenic systems. Pathogens and Global Health, 107 (8). p. 451. ISSN 2047-7724.

Papathanos, Philippos A. and Akbari, Omar S. and Hay, Bruce A. (2013) A Toolbox of Aedes Aegypti Germline Regulatory Elements for the Development of Genetic Drive Systems and Population Control. Pathogens and Global Health, 107 (8). p. 445. ISSN 2047-7724.

Akbari, Omar S. and Amrhein, Henry and Williams, Brian et al. (2013) The Developmental Transcriptome of the Mosquito Aedes aegypti, an Invasive Species and Major Arbovirus Vector. G3, 3 (9). pp. 1493-1509. ISSN 2160-1836. PMCID PMC3755910.

Akbari, Omar S. and Antoshechkin, Igor and Hay, Bruce A. et al. (2013) Transcriptome Profiling of Nasonia vitripennis Testis Reveals Novel Transcripts Expressed from the Selfish B Chromosome, Paternal Sex Ratio. G3, 3 (9). pp. 1597-1605. ISSN 2160-1836. PMCID PMC3755920.

Akbari, Omar S. and Matzen, Kelly D. and Marshall, John M. et al. (2013) A Synthetic Gene Drive System for Local, Reversible Modification and Suppression of Insect Populations. Current Biology, 23 (8). pp. 671-677. ISSN 0960-9822.

Lee, Gyunghee and Sehgal, Ritika and Wang, Zixing et al. (2013) Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster. Biology Open, 2 (3). pp. 283-294. ISSN 2046-6390. PMCID PMC3603410.


Marshall, John M. and Hay, Bruce A. (2012) General principles of single-construct chromosomal gene drive. Evolution, 66 (7). pp. 2150-2166. ISSN 0014-3820. PMCID PMC3389707.

Marshall, John M. and Hay, Bruce A. (2012) Confinement of gene drive systems to local populations: A comparative analysis. Journal of Theoretical Biology, 294 . pp. 153-171. ISSN 0022-5193. PMCID PMC3260013.

Rochet, Jean-Christophe and Hay, Bruce A. and Guo, Ming (2012) Molecular Insights into Parkinson’s Disease. In: Molecular Biology of Neurodegenerative Diseases. Progress in Molecular Biology and Translational Science . No.107. Academic Press , Amsterdam, pp. 125-188. ISBN 9780123858832.


Marshall, John M. and Hay, Bruce A. (2011) Inverse Medea as a Novel Gene Drive System for Local Population Replacement: A Theoretical Analysis. Journal of Heredity, 102 (3). pp. 336-341. ISSN 0022-1503. PMCID PMC3076586.

Ward, Catherine M. and Su, Jessica T. and Huang, Yunxin et al. (2011) Medea Selfish Genetic Elements as Tools for Altering Traits of Wild Populations: A Theoretical Analysis. Evolution, 65 (4). pp. 1149-1162. ISSN 0014-3820. PMCID PMC3601553.

Marshall, John M. and Pittman, Geoffrey W. and Buchman, Anna B. et al. (2011) Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations. Genetics, 187 (2). pp. 535-551. ISSN 0016-6731. PMCID PMC3030495.

Lee, Gyunghee and Wang, Zixing and Sehgal, Ritika et al. (2011) Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. Journal of Comparative Neurology, 519 (1). pp. 34-48. ISSN 0021-9967.


Hay, Bruce A. and Chen, Chun-Hong and Ward, Catherine M. et al. (2010) Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements. Journal of Insect Physiology, 56 (10). pp. 1402-1413. ISSN 0022-1910. PMCID PMC3601555.

Siegrist, Sarah E. and Haque, Najm S. and Chen, Chun-Hong et al. (2010) Inactivation of Both foxo and reaper Promotes Long-Term Adult Neurogenesis in Drosophila. Current Biology, 20 (7). pp. 643-648. ISSN 0960-9822. PMCID PMC2862284.


Ribaya, Jeronimo P. and Ranmuthu, Madhuka and Copeland, Jeff et al. (2009) The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila. Developmental Biology, 329 (1). pp. 25-35. ISSN 0012-1606.


Hawkins, Julie L. and Robbins, Michael D. and Warren, Laurie C. et al. (2008) Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals. Journal of Pharmacology and Experimental Therapeutics, 326 (3). pp. 801-808. ISSN 0022-3565.

Sathyanarayanan, Sriram and Zheng, Xiangzhong and Kumar, Shailes et al. (2008) Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Genes and Development, 22 (11). pp. 1522-1533. ISSN 0890-9369. PMCID PMC2418588.

Yao, Jih-Guang and Weasner, Bonnie M. and Wang, Lan-Hsin et al. (2008) Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila. Developmental Biology, 315 (2). pp. 535-551. ISSN 0012-1606. PMCID PMC2702218.


Shcherbata, Halyna R. and Ward, Ellen J. and Fischer, Karin A. et al. (2007) Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary. Cell Stem Cell, 1 (6). pp. 698-709. ISSN 1934-5909. PMCID PMC2211735.

Hay, Bruce A. and Abrams, Barbara and Zumbrunn, Allice Y. et al. (2007) Aminopyrrolidineamide inhibitors of site-1 protease. Bioorganic and Medicinal Chemistry Letters, 17 (16). pp. 4411-4414. ISSN 0960-894X.

Copeland, Jeffrey M. and Bosdet, Ian and Freeman, J. Douglas et al. (2007) echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases. BMC Developmental Biology, 7 (82). ISSN 1471-213X. PMCID PMC1950886.

Chen, Chun-Hong and Huang, Haixia and Ward, Catherine M. et al. (2007) A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila. Science, 316 (5824). pp. 597-600. ISSN 0036-8075.

Huh, Jun R. and Foe, Ian and Muro, Israel et al. (2007) The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers. Journal of Biological Chemistry, 282 (3). pp. 2056-2068. ISSN 0021-9258.


Hay, Bruce A. and Guo, Ming (2006) Caspase-Dependent Cell Death in Drosophila. Annual Review of Cell and Developmental Biology, 22 . pp. 623-650. ISSN 1081-0706.

Chen, Chun-Hong and Guo, Ming and Hay, Bruce A. (2006) Identifying MicroRNA Regulators of Cell Death in Drosophila. In: MicroRNA Protocols. Methods in Molecular Biology. No.342. Humana Press , Totowa, NJ, pp. 229-240. ISBN 978-1-58829-581-1.

Muro, Israel and Berry, Deborah L. and Huh, Jun R. et al. (2006) The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development, 133 (17). pp. 3305-3315. ISSN 0950-1991.

Clark, Ira E. and Dodson, Mark W. and Cao, Joseph H. et al. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature, 441 (7097). pp. 1162-1166. ISSN 0028-0836.

Yan, Nieng and Huh, Jun R. and Schirf, Virgil et al. (2006) Structure and Activation Mechanism of the Drosophila Initiator Caspase Dronc. Journal of Biological Chemistry, 281 (13). pp. 8667-8674. ISSN 0021-9258.


Xu, Peizhang and Guo, Ming and Hay, Bruce A. (2004) MicroRNAs and the regulation of cell death. Trends in Genetics, 20 (12). pp. 617-624. ISSN 0168-9525.

Hay, Bruce A. and Huh, Jun R. and Guo, Ming (2004) The genetics of cell death: approaches, insights and opportunities in Drosophila. Nature Reviews. Genetics, 5 (12). pp. 911-922. ISSN 1471-0056.

Huh, Jun R. and Guo, Ming and Hay, Bruce A. (2004) Compensatory Proliferation Induced by Cell Death in the Drosophila Wing Disc Requires Activity of the Apical Cell Death Caspase Dronc in a Nonapoptotic Role. Current Biology, 14 (14). pp. 1262-1266. ISSN 0960-9822.

Huh, Jun R. and Vernooy, Stephanie Y. and Yu, Hong et al. (2004) Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization. PLoS Biology, 2 (1). pp. 43-53. ISSN 1544-9173. PMCID PMC300883.


Chai, Jijie and Yan, Nieng and Huh, Jun R. et al. (2003) Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nature Structural Biology, 10 (11). pp. 892-898. ISSN 1072-8368.

Guo, Ming and Hong, Elizabeth J. and Fernandes, Jolene et al. (2003) A reporter for amyloid precursor protein γ-secretase activity in Drosophila. Human Molecular Genetics, 12 (20). pp. 2669-2678. ISSN 0964-6906.

Hay, Bruce A. and Guo, Ming (2003) Coupling Cell Growth, Proliferation, and Death: Hippo Weighs In. Developmental Cell, 5 (3). pp. 361-363. ISSN 1534-5807.

Xu, Peizhang and Vernooy, Stephanie Y. and Guo, Ming et al. (2003) The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism. Current Biology, 13 (9). pp. 790-795. ISSN 0960-9822.

Olson, Michael R. and Holley, Christopher L. and Yoo, Soon Ji et al. (2003) Reaper is regulated by IAP-mediated ubiquitination. Journal of Biological Chemistry, 278 (6). pp. 4028-4034. ISSN 0021-9258.


Muro, Israel and Hay, Bruce A. and Clem, Rollie J. (2002) The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC. Journal of Biological Chemistry, 277 (51). pp. 49644-49650. ISSN 0021-9258.

Huh, Jun R. and Hay, Bruce A. (2002) Apoptosis - Sculpture of a fly's head. Nature, 418 (6901). pp. 926-928. ISSN 0028-0836.

Vernooy, Stephanie Y. and Chow, Vivian and Su, Julius et al. (2002) Drosophila Bruce Can Potently Suppress Rpr- and Grim-Dependent but Not Hid-Dependent Cell Death. Current Biology, 12 (13). pp. 1164-1168. ISSN 0960-9822.

Yu, Sun-Yun and Yoo, Soon Ji and Yang, Lihui et al. (2002) A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development, 129 (13). pp. 3269-3278. ISSN 0950-1991.

Yoo, Soon Ji and Huh, Jun R. and Muro, Israel et al. (2002) Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nature Cell Biology, 4 (6). pp. 416-424. ISSN 1465-7392.

Dorstyn, Loretta and Read, Stuart and Cakouros, Dimitrios et al. (2002) The role of cytochrome c in caspase activation in Drosophila melanogaster cells. Journal of Cell Biology, 156 (6). pp. 1089-1098. ISSN 0021-9525. PMCID PMC2173478.


Hay, Bruce A. and Cole, Bridget M. and DiCapua, Frank et al. (2001) Small molecule somatostatin receptor subtype-2 antagonists. Bioorganic and Medicinal Chemistry Letters, 11 (20). pp. 2731-2734. ISSN 0960-894X.

Wu, Jia-Wei and Cocina, Amy E. and Chai, Jijie et al. (2001) Structural Analysis of a Functional DIAP1 Fragment Bound to Grim and Hid Peptides. Molecular Cell, 8 (1). pp. 95-104. ISSN 1097-2765.


Hay, B. A. (2000) Understanding IAP function and regulation: a view from Drosophila. Cell Death and Differentiation, 7 (11). pp. 1045-1056. ISSN 1350-9047.

Hawkins, Christine J. and Yoo, Soon Ji and Peterson, Erin P. et al. (2000) The Drosophila Caspase DRONC Cleaves following Glutamate or Aspartate and Is Regulated by DIAP1, HID, and GRIM. Journal of Biological Chemistry, 275 (35). pp. 27084-27093. ISSN 0021-9258.

Vernooy, Stephanie Y. and Copeland, Jeffrey and Ghaboosi, Nazli et al. (2000) Cell death regulation in Drosophila: Conservation of mechanism and unique insights. Journal of Cell Biology, 150 (2). F69-F75. ISSN 0021-9525. PMCID PMC2180229.

Rubin, Gerald M. and Hay, Bruce A. (2000) Comparative Genomics of the Eukaryotes. Science, 287 (5461). pp. 2204-2215. ISSN 0036-8075. PMCID PMC2754258.

Hawkins, Christine J. and Wang, Susan L. and Hay, Bruce A. (2000) Monitoring Activity of Caspases and Their Regulators in Yeast Saccharomyces cerevisiae. In: Apoptosis. Methods in Enzymology. No.322. Academic Press , London, pp. 162-174. ISBN 9780121822231.


Guo, Ming and Hay, Bruce A. (1999) Cell proliferation and apoptosis. Current Opinion in Cell Biology, 11 (6). pp. 745-752. ISSN 0955-0674.

Wang, Susan L. and Hawkins, Christine J. and Yoo, Soon Ji et al. (1999) The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID. Cell, 98 (4). pp. 453-463. ISSN 0092-8674.

Hawkins, Christine J. and Wang, Susan L. and Hay, Bruce A. (1999) A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. Proceedings of the National Academy of Sciences of the United States of America, 96 (6). pp. 2885-2890. ISSN 0027-8424. PMCID PMC15864.


Hay, Bruce A. and Maile, Randy and Rubin, Gerald M. (1997) P element insertion-dependent gene activation in the Drosophila eye. Proceedings of the National Academy of Sciences of the United States of America, 94 (10). pp. 5195-5200. ISSN 0027-8424. PMCID PMC24655.


Hay, Bruce A. and Wassarman, David A. and Rubin, Gerald M. (1995) Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell, 83 (7). pp. 1253-1262. ISSN 0092-8674.


Hay, Bruce A. and Wolff, Tanya and Rubin, Gerald M. (1994) Expression of baculovirus P35 prevents cell death in Drosophila. Development, 120 (8). pp. 2121-2129. ISSN 0950-1991.


Jongens, Thomas A. and Hay, Bruce and Jan, Lily Yeh et al. (1992) The germ cell-less gene product: A posteriorly localized component necessary for germ cell development in Drosophila. Cell, 70 (4). pp. 569-584. ISSN 0092-8674.


Hay, Bruce and Jan, Lily Yeh and Jan, Yuh Nung (1990) Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. Development, 109 (2). pp. 425-433. ISSN 0950-1991.


Hay, Bruce and Jan, Lily Yeh and Jan, Yuh Nung (1988) A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases. Cell, 55 (4). pp. 577-587. ISSN 0092-8674.

Hay, Bruce A. and Ackerman, Larry and Barbel, Sandra et al. (1988) Identification of a component of Drosophila polar granules. Development, 103 (4). pp. 625-640. ISSN 0950-1991.


Hay, Bruce and Prusiner, Stanley B. and Lingappa, Vishwanath R. (1987) Evidence for a secretory form of the cellular prion protein. Biochemistry, 26 (25). pp. 8110-8115. ISSN 0006-2960.

McKinley, Michael P. and Hay, Bruce and Lingappa, Vishwanath R. et al. (1987) Developmental expression of prion protein gene in brain. Developmental Biology, 121 (1). pp. 105-110. ISSN 0012-1606.

Hay, Bruce and Barry, Ronald A. and Lieberburg, Ivan et al. (1987) Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein. Molecular and Cellular Biology, 7 (2). pp. 914-920. ISSN 0270-7306. PMCID PMC365150; PMC365316.

This list was generated on Mon Oct 26 12:12:45 2020 PDT.