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Number of items: 309.

2020

Cohen, Bruce N. and Nichols, Aaron L. and Grant, Stephen et al. (2020) Successful Cessation Programs that Reduce Comorbidity May Explain Surprisingly Low Smoking Rates Among Hospitalized COVID-19 Patients. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20200526-135356434

Borden, Philip M. and Shivange, Amol V. and Lester, Henry A. et al. (2020) A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20200210-132609996

Grant, Stephen and Muthusamy, Anand K. and Collazo, Andres et al. (2020) Antagonists Pharmacologically Chaperone Opioid Receptors. Biophysical Journal, 118 (3). 27a. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20200210-091504115

Mulcahy, Matthew J. and Huard, Stephanie M. and Paulo, Joao A. et al. (2020) Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure. Journal of Proteome Research, 19 (1). pp. 36-48. ISSN 1535-3893. PMCID PMC7289315. https://resolver.caltech.edu/CaltechAUTHORS:20191028-111942058

2019

Bera, Kallol and Kamajaya, Aron and Shivange, Amol V. et al. (2019) Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum. Frontiers in Cellular Neuroscience, 13 . Art. No. 499. ISSN 1662-5102. PMCID PMC6874132. https://resolver.caltech.edu/CaltechAUTHORS:20191218-090117543

Lester, Henry A. and Dougherty, Dennis A. (2019) Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem. Neuron, 104 (3). pp. 431-432. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20191106-094121720

Blom, Annet E. M. and Rego Campello, Hugo and Lester, Henry A. et al. (2019) Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor. Journal of the American Chemical Society, 141 (40). pp. 15840-15849. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20190916-135720189

Shivange, Amol V. and Borden, Philip M. and Muthusamy, Anand K. et al. (2019) Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. Journal of General Physiology, 151 (6). pp. 738-757. ISSN 0022-1295. PMCID PMC6571994. https://resolver.caltech.edu/CaltechAUTHORS:20190204-103658076

Bavan, Selvan and Kim, Charlene H. and Henderson, Brandon J. et al. (2019) Chronic menthol does not change stoichiometry or functional plasma membrane levels of mouse α3β4-containing nicotinic acetylcholine receptors. Molecular Pharmacology, 95 (4). pp. 398-407. ISSN 0026-895X. PMCID PMC6399576. https://resolver.caltech.edu/CaltechAUTHORS:20190128-151017476

Zhou, Chunyi and Gu, Weixin and Wu, Haichuan et al. (2019) Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs. Neuropharmacology, 148 . pp. 220-228. ISSN 0028-3908. https://resolver.caltech.edu/CaltechAUTHORS:20190123-075807331

2018

Henderson, Brandon J. and Grant, Stephen and Chu, Betty W. et al. (2018) Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing. eNeuro, 5 (6). Art. No. e0465-18.2018. ISSN 2373-2822. PMCID PMC6325563. https://resolver.caltech.edu/CaltechAUTHORS:20190111-101254546

Nichols, Aaron L. and Noridomi, Kaori and Hughes, Christopher R. et al. (2018) α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor. ACS Chemical Biology, 13 (9). pp. 2568-2576. ISSN 1554-8929. https://resolver.caltech.edu/CaltechAUTHORS:20180924-141114616

Subramaniam, Sudhakar R. and Magen, Iddo and Bove, Nicholas et al. (2018) Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein. Neurobiology of Disease, 117 . pp. 170-180. ISSN 0969-9961. PMCID PMC6051902. https://resolver.caltech.edu/CaltechAUTHORS:20180611-095839803

Banala, Sambashiva and Arvin, Matthew C. and Bannon, Nicholas M. et al. (2018) Photoactivatable drugs for nicotinic optopharmacology. Nature Methods, 15 (5). pp. 347-350. ISSN 1548-7091. PMCID PMC5923430. https://resolver.caltech.edu/CaltechAUTHORS:20180402-095419703

Bavan, Selvan and Patowary, Suparna and Kim, Charlene H. et al. (2018) Effects of Chronic Menthol at Alpha3Beta4 (α3β4)-Containing Nicotinic Acetylcholine Receptors. Biophysical Journal, 114 (3). 296A. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20180523-144402903

Muthusamy, Anand K. and Shivange, Amol V. and Nichols, Aaron L. et al. (2018) Microscopy Using Fluorescent Drug Biosensors for "Inside-Out Pharmacology". Biophysical Journal, 114 (3). 358A. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20180523-150441864

2017

Parker, Rell L. and O’Neill, Heidi C. and Henley, Beverley M. et al. (2017) Deletion of lynx1 reduces the function of α6* nicotinic receptors. PLoS ONE, 12 (12). Art. No. e0188715. ISSN 1932-6203. PMCID PMC5716591. https://resolver.caltech.edu/CaltechAUTHORS:20171211-155148787

Henderson, Brandon J. and Wall, Teagan R. and Henley, Beverley M. et al. (2017) Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability. Neuropsychopharmacology, 42 (12). pp. 2285-2291. ISSN 0893-133X. PMCID PMC5645749. https://resolver.caltech.edu/CaltechAUTHORS:20170418-150133796

Tarren, Josephine R. and Lester, Henry A. and Belmer, Arnauld et al. (2017) Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala. Frontiers in Molecular Neuroscience, 10 . Art. No. 338. ISSN 1662-5099. PMCID PMC5660714. https://resolver.caltech.edu/CaltechAUTHORS:20171113-110814227

Shivange, Amol V. and Nichols, Aaron L. and Borden, Philip M. et al. (2017) Nicotine in the Endoplasmic Reticulum. Journal of General Physiology, 149 (9). Art. No. 32. ISSN 0022-1295. https://resolver.caltech.edu/CaltechAUTHORS:20170929-092012776

Wall, Teagan R. and Henderson, Brandon J. and Voren, George et al. (2017) TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Frontiers in Pharmacology, 8 . Art. No. 641. ISSN 1663-9812. PMCID PMC5626944. https://resolver.caltech.edu/CaltechAUTHORS:20171013-114018950

Mulcahy, Matthew J. and Lester, Henry A. (2017) Granulocytes as models for human protein marker identification following nicotine exposure. Journal of Neurochemistry, 142 . pp. 151-161. ISSN 0022-3042. PMCID PMC6057152. https://resolver.caltech.edu/CaltechAUTHORS:20170809-134755993

Hurtado-Zavala, Joaquin I. and Ramachandran, Binu and Ahmed, Saheeb et al. (2017) TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus. Nature Communications, 8 . Art. No. 15878. ISSN 2041-1723. PMCID PMC5524938. https://resolver.caltech.edu/CaltechAUTHORS:20170724-083914067

Kim, Jinho and Henley, Beverley M. and Kim, Charlene H. et al. (2017) Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy. In: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV. Proceedings of SPIE. No.10068. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 100680X. ISBN 9781510605770. https://resolver.caltech.edu/CaltechAUTHORS:20170831-081004023

Post, Michael R. and Lester, Henry A. and Dougherty, Dennis A. (2017) Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors. Biochemistry, 56 (13). pp. 1836-1840. ISSN 0006-2960. PMCID PMC6075822. https://resolver.caltech.edu/CaltechAUTHORS:20170314-072647704

Mulcahy, Matthew J. and Wang, Jonathan H. and Lester, Henry A. (2017) Region specific proteomic analysis of murine brain after chronic nicotine or menthol. FASEB Journal, 31 (S1). Art. No. 991.1. ISSN 0892-6638. https://resolver.caltech.edu/CaltechAUTHORS:20170921-153023998

Post, Michael R. and Tender, Gabrielle S. and Lester, Henry A. et al. (2017) Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors. eNeuro, 4 (2). Art. No. 0032-17. ISSN 2373-2822. PMCID PMC5458768. https://resolver.caltech.edu/CaltechAUTHORS:20170612-100040551

Henley, Beverley M. and Cohen, Bruce N. and Kim, Charlene H. et al. (2017) Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP Expression. Journal of Visualized Experiments (120). Art. No. 54981. ISSN 1940-087X. PMCID PMC5409190. https://resolver.caltech.edu/CaltechAUTHORS:20170320-104204700

2016

Kim, Jinho and Henley, Beverley M. and Kim, Charlene H. et al. (2016) Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy. Biomedical Optics Express, 7 (8). pp. 3097-3110. ISSN 2156-7085. PMCID PMC4986817. https://resolver.caltech.edu/CaltechAUTHORS:20160801-135931634

Nichols, Weston A. and Henderson, Brandon J. and Marotta, Christopher B. et al. (2016) Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression. PLoS ONE, 11 (6). Art. No. e0158032. ISSN 1932-6203. PMCID PMC4918917. https://resolver.caltech.edu/CaltechAUTHORS:20160706-102113506

Henderson, Brandon J. and Wall, Teagan R. and Henley, Beverley M. et al. (2016) Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward. Journal of Neuroscience, 36 (10). pp. 2957-2974. ISSN 0270-6474. PMCID PMC4783498. https://resolver.caltech.edu/CaltechAUTHORS:20160315-105822806

Post, Michael R. and Lester, Henry and Dougherty, Dennis A. (2016) Probing binding interactions of agonists at a nicotinic acetylcholine receptor subtype important to addiction and Parkinson's disease. In: 251st American Chemical Society National Meeting & Exposition, March 13-17, 2016, San Diego, CA. https://resolver.caltech.edu/CaltechAUTHORS:20160414-084908996

Patowary, Suparna and Mackey, Elisha D. W. and McKinney, Sheri L. et al. (2016) Effects of Menthol on α3β4∗ Nicotinic Receptors. Biophysical Journal, 110 (3). 603A. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20160606-140410523

Post, Michael R. and Dougherty, Dennis A. and Lester, Henry A. (2016) Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor. Biophysical Journal, 110 (3). 603A. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20160606-140109728

Srinivasan, Rahul and Henley, Beverley M. and Henderson, Brandon J. et al. (2016) Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. Journal of Neuroscience, 36 (1). pp. 65-79. ISSN 0270-6474. PMCID PMC4701966. https://resolver.caltech.edu/CaltechAUTHORS:20160111-082423100

2015

Lester, Henry A. and Lavis, Luke D. and Dougherty, Dennis A. (2015) Ketamine Inside Neurons? American Journal of Psychiatry, 172 (11). pp. 1064-1066. ISSN 0002-953X. PMCID PMC6107348. https://resolver.caltech.edu/CaltechAUTHORS:20150728-082757273

Post, Michael R. and Limapichat, Walrati and Lester, Henry A. et al. (2015) Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors. Neuropharmacology, 97 . pp. 376-382. ISSN 0028-3908. PMCID PMC4635625. https://resolver.caltech.edu/CaltechAUTHORS:20150429-110737552

Henderson, Brandon J. and Lester, Henry A. (2015) Inside-out neuropharmacology of nicotinic drugs. Neuropharmacology, 96 . pp. 178-193. ISSN 0028-3908. PMCID PMC4486611. https://resolver.caltech.edu/CaltechAUTHORS:20150211-075813471

Sinkus, Melissa L. and Graw, Sharon and Freedman, Robert et al. (2015) The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function. Neuropharmacology, 96 . pp. 274-288. ISSN 0028-3908. PMCID PMC4486515. https://resolver.caltech.edu/CaltechAUTHORS:20150224-151714505

Marotta, Christopher B. and Lester, Henry A. and Dougherty, Dennis A. (2015) An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors. Chemistry and Biology, 22 (8). pp. 1063-1073. ISSN 1074-5521. PMCID PMC4547686. https://resolver.caltech.edu/CaltechAUTHORS:20150728-085848506

Wieskopf, Jeffrey S. and Limapichat, Walrati and Post, Michael R. et al. (2015) The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Science Translational Medicine, 7 (287). Art. No. 287ra72. ISSN 1946-6234. PMCID PMC5018401. https://resolver.caltech.edu/CaltechAUTHORS:20150519-092649728

Miles, Timothy F. and Lester, Henry A. and Dougherty, Dennis A. (2015) Allosteric activation of the 5-HT_3AB receptor by mCPBG. Neuropharmacology, 91 . pp. 103-108. ISSN 0028-3908. PMCID PMC4312754. https://resolver.caltech.edu/CaltechAUTHORS:20150106-073218861

Xiao, Cheng and Miwa, Julie M. and Henderson, Brandon J. et al. (2015) Nicotinic Receptor Subtype-Selective Circuit Patterns in the Subthalamic Nucleus. Journal of Neuroscience, 35 (9). pp. 3734-3746. ISSN 0270-6474. PMCID PMC4348180. https://resolver.caltech.edu/CaltechAUTHORS:20150309-153924379

2014

Nichols, Weston A. and Henderson, Brandon J. and Yu, Caroline et al. (2014) Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum. Journal of Biological Chemistry, 289 (45). pp. 31423-31432. ISSN 0021-9258. PMCID PMC4223341. https://resolver.caltech.edu/CaltechAUTHORS:20140915-092705574

Daeffler, Kristina N.-M. and Lester, Henry A. and Dougherty, Dennis A. (2014) Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl. ACS Chemical Biology, 9 (10). pp. 2283-2290. ISSN 1554-8929. PMCID PMC4201344. https://resolver.caltech.edu/CaltechAUTHORS:20140811-132238553

Wang, Ying and Xiao, Cheng and Indersmitten, Tim et al. (2014) The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7. Journal of Biological Chemistry, 289 (38). pp. 26451-26463. ISSN 0021-9258. PMCID PMC4176222. https://resolver.caltech.edu/CaltechAUTHORS:20140729-082327052

Limapichat, Walrati and Dougherty, Dennis A. and Lester, Henry A. (2014) Subtype-Specific Mechanisms for Functional Interaction between α6β4* Nicotinic Acetylcholine Receptors and P2X Receptors. Molecular Pharmacology, 86 (3). pp. 263-274. ISSN 0026-895X. PMCID PMC4152909. https://resolver.caltech.edu/CaltechAUTHORS:20141016-090934738

Kobayashi, Atsuko and Parker, Rell L. and Wright, Ashley P. et al. (2014) lynx1 Supports Neuronal Health in the Mouse Dorsal Striatum During Aging: an Ultrastructural Investigation. Journal of Molecular Neuroscience, 53 (3). pp. 525-536. ISSN 0895-8696. PMCID PMC4265479. https://resolver.caltech.edu/CaltechAUTHORS:20140721-090832827

Shih, Pei-Yu and Engle, Staci E. and Oh, Gyeon et al. (2014) Differential Expression and Function of Nicotinic Acetylcholine Receptors in Subdivisions of Medial Habenula. Journal of Neuroscience, 34 (29). pp. 9789-9802. ISSN 0270-6474. PMCID PMC4099552. https://resolver.caltech.edu/CaltechAUTHORS:20140814-112513666

Marotta, Christopher B. and Rreza, Iva and Lester, Henry A. et al. (2014) Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors. ACS Chemical Biology, 9 (5). pp. 1153-1159. ISSN 1554-8929. PMCID PMC4033646. https://resolver.caltech.edu/CaltechAUTHORS:20170302-160217090

Srinivasan, Rahul and Henderson, Brandon J. and Lester, Henry A. et al. (2014) Pharmacological chaperoning of nAChRs: A therapeutic target for Parkinson's disease. Pharmacological Research, 83 . pp. 20-29. ISSN 1043-6618. PMCID PMC6075820. https://resolver.caltech.edu/CaltechAUTHORS:20140724-150050094

Lester, Henry and Cohen, Bruce (2014) Drugs and the brain, the MOOC. FASEB Journal, 28 (1). 221.2. ISSN 0892-6638. https://resolver.caltech.edu/CaltechAUTHORS:20150205-130837428

Marotta, Christopher B. and Dilworth, Crystal N. and Lester, Henry A. et al. (2014) Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor. Neuropharmacology, 77 . pp. 342-349. ISSN 0028-3908. PMCID PMC3934363. https://resolver.caltech.edu/CaltechAUTHORS:20140227-142503676

Marotta, Christopher and Lester, Henry A. and Dougherty, Dennis A. (2014) Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors. Biophysical Journal, 106 (2). 341A. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20140710-092155936

Post, Michael R. and Lester, Henry A. and Dougherty, Dennis A. (2014) Structure Function Studies at Two Different Nicotinic Acetylcholine Receptor Subtypes. Biophysical Journal, 106 (2). 341A. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20140710-095141475

Lester, Henry (2014) Drug Actions on Nicotinic Receptors. Chronic vs Acute; Outside-in vs Inside-out. Neuropsychopharmacology, 39 (S1). pp. 581-582. ISSN 0893-133X. https://resolver.caltech.edu/CaltechAUTHORS:20150108-114406249

2013

Henderson, Brandon J. and Srinivasan, Rahul and Nichols, Weston A. et al. (2013) Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. Journal of General Physiology, 143 (1). pp. 51-66. ISSN 0022-1295. PMCID PMC3874574. https://resolver.caltech.edu/CaltechAUTHORS:20140123-151832351

Henley, Beverley M. and Williams, Brian A. and Srinivasan, Rahul et al. (2013) Transcriptional regulation by nicotine in dopaminergic neurons. Biochemical Pharmacology, 86 (8). pp. 1074-1083. ISSN 0006-2952. PMCID PMC3969234. https://resolver.caltech.edu/CaltechAUTHORS:20130815-073947290

Miles, Timothy F. and Dougherty, Dennis A. and Lester, Henry A. (2013) The 5-HT_3AB Receptor Shows an A_3B_2 Stoichiometry at the Plasma Membrane. Biophysical Journal, 105 (4). pp. 887-898. ISSN 0006-3495. PMCID PMC3752109. https://resolver.caltech.edu/CaltechAUTHORS:20130912-145808068

Van Arnam, Ethan B. and Blythe, Emily E. and Lester, Henry A. et al. (2013) An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline. Molecular Pharmacology, 84 (2). pp. 201-207. ISSN 0026-895X. PMCID PMC3716316. https://resolver.caltech.edu/CaltechAUTHORS:20130808-161341375

Frazier, Shawnalea J. and Cohen, Bruce N. and Lester, Henry A. (2013) An Engineered Glutamate-gated Chloride (GluCl) Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin. Journal of Biological Chemistry, 288 (29). pp. 21029-21042. ISSN 0021-9258. PMCID PMC3774370. https://resolver.caltech.edu/CaltechAUTHORS:20130909-090111946

Chatterjee, Susmita and Santos, Nathan and Holgate, Joan et al. (2013) The α5 Subunit Regulates the Expression and Function of α4*-Containing Neuronal Nicotinic Acetylcholine Receptors in the Ventral-Tegmental Area. PLoS ONE, 8 (7). Art. No. e68300. ISSN 1932-6203. PMCID PMC3712017. https://resolver.caltech.edu/CaltechAUTHORS:20130909-105437251

Blum, Angela P. and Van Arnam, Ethan B. and German, Laurel A. et al. (2013) Binding Interactions with the Complementary Subunit of Nicotinic Receptors. Journal of Biological Chemistry, 288 (10). pp. 6991-6997. ISSN 0021-9258. PMCID PMC3591609. https://resolver.caltech.edu/CaltechAUTHORS:20130411-103637479

Limapichat, Walrati and Yu, Wesley Y. and Branigan, Emma et al. (2013) Key Binding Interactions for Memantine in the NMDA Receptor. ACS Chemical Neuroscience, 4 (2). pp. 255-260. ISSN 1948-7193. PMCID PMC3751542. https://resolver.caltech.edu/CaltechAUTHORS:20130328-101734866

O'Neill, Heidi C. and Laverty, Duncan C. and Patzlaff, Natalie E. et al. (2013) Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function. Pharmacology Biochemistry and Behavior, 103 (3). pp. 603-621. ISSN 0091-3057. PMCID PMC3544981. https://resolver.caltech.edu/CaltechAUTHORS:20130319-103616459

2012

Lester, Henry A. and Miwa, Julie M. and Srinivasan, Rahul (2012) Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic Pathways: Therapeutic Effects. Biological Psychiatry, 72 (11). pp. 907-915. ISSN 0006-3223. PMCID PMC6167061. https://resolver.caltech.edu/CaltechAUTHORS:20121217-074942263

Miles, Timothy F. and Bower, Kiowa S. and Lester, Henry A. et al. (2012) A Coupled Array of Noncovalent Interactions Impacts the Function of the 5‑HT_3A Serotonin Receptor in an Agonist-Specific Way. ACS Chemical Neuroscience, 3 (10). pp. 753-760. ISSN 1948-7193. PMCID PMC3474281. https://resolver.caltech.edu/CaltechAUTHORS:20121127-103848210

Scott, Kimberly M. and Du, Jiangang and Lester, Henry A. et al. (2012) Variability of acute extracellular action potential measurements with multisite silicon probes. Journal of Neuroscience Methods, 211 (1). pp. 22-30. ISSN 0165-0270. PMCID PMC3473102. https://resolver.caltech.edu/CaltechAUTHORS:20121217-082045717

Drenan, Ryan M. and Lester, Henry A. (2012) Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations. Pharmacological Reviews, 64 (4). pp. 869-879. ISSN 0031-6997. PMCID PMC3462994. https://resolver.caltech.edu/CaltechAUTHORS:20121108-131347078

Duffy, Noah H. and Lester, Henry A. and Dougherty, Dennis A. (2012) Ondansetron and Granisetron Binding Orientation in the 5‑HT_3 Receptor Determined by Unnatural Amino Acid Mutagenesis. ACS Chemical Biology, 7 (10). pp. 1738-1745. ISSN 1554-8929. PMCID PMC3477246. https://resolver.caltech.edu/CaltechAUTHORS:20121127-104931725

Daeffler, Kristina N.-M. and Lester, Henry A. and Dougherty, Dennis A. (2012) Functionally Important Aromatic–Aromatic and Sulfur−π Interactions in the D2 Dopamine Receptor. Journal of the American Chemical Society, 134 (36). pp. 14890-14896. ISSN 0002-7863. PMCID PMC3461201. https://resolver.caltech.edu/CaltechAUTHORS:20121031-153603159

Liu, Cambrian Y. and Xiao, Cheng and Fraser, Scott E. et al. (2012) Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents. Journal of Neurophysiology, 108 (5). pp. 1318-1334. ISSN 0022-3077. PMCID PMC3544954. https://resolver.caltech.edu/CaltechAUTHORS:20120910-073630839

Shapiro, Mikhail G. and Frazier, Shawnalea J. and Lester, Henry A. (2012) Unparalleled Control of Neural Activity Using Orthogonal Pharmacogenetics. ACS Chemical Neuroscience, 3 (8). pp. 619-629. ISSN 1948-7193. PMCID PMC3419455. https://resolver.caltech.edu/CaltechAUTHORS:20120926-114816752

Miwa, Julie M. and Lester, Henry A. and Walz, Andreas (2012) Optimizing Cholinergic Tone Through Lynx Modulators of Nicotinic Receptors: Implications for Plasticity and Nicotine Addiction. Physiology, 27 (4). pp. 187-199. ISSN 1548-9221. https://resolver.caltech.edu/CaltechAUTHORS:20120924-131621260

Srinivasan, Rahul and Richards, Christopher I. and Dilworth, Crystal et al. (2012) Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2. International Journal of Molecular Sciences, 13 (8). pp. 10022-10040. ISSN 1422-0067. PMCID PMC3431844. https://resolver.caltech.edu/CaltechAUTHORS:20120907-141513430

Mackey, Elisha D. W. and Engle, Staci E. and Kim, Mi Ran et al. (2012) α6* Nicotinic Acetylcholine Receptor Expression and Function in a Visual Salience Circuit. Journal of Neuroscience, 32 (30). pp. 10226-10237. ISSN 0270-6474. PMCID PMC3432940. https://resolver.caltech.edu/CaltechAUTHORS:20120904-085001085

Tavares, Ximena Da Silva and Blum, Angela P. and Nakamura, Darren T. et al. (2012) Variations in Binding Among Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic Receptor. Journal of the American Chemical Society, 134 (28). pp. 11474-11480. ISSN 0002-7863. PMCID PMC3399941. https://resolver.caltech.edu/CaltechAUTHORS:20120824-131040943

Richards, Christopher I. and Luong, Khai and Srinivasan, Rahul et al. (2012) Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures. Nano Letters, 12 (7). pp. 3690-3694. ISSN 1530-6984. PMCID PMC3397148. https://resolver.caltech.edu/CaltechAUTHORS:20120813-111734004

Puskar, Nyssa L. and Lester, Henry A. and Dougherty, Dennis A. (2012) Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor. ACS Chemical Biology, 7 (5). pp. 841-846. ISSN 1554-8929. PMCID PMC3356501. https://resolver.caltech.edu/CaltechAUTHORS:20120613-133532352

Srinivasan, Rahul and Richards, Christopher I. and Xiao, Cheng et al. (2012) Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response. Molecular Pharmacology, 81 (6). pp. 759-769. ISSN 0026-895X. PMCID PMC3362896. https://resolver.caltech.edu/CaltechAUTHORS:20120530-081520292

Murray, Teresa A. and Bertrand, Daniel and Papke, Roger L. et al. (2012) α7β2 Nicotinic Acetylcholine Receptors Assemble, Function, and Are Activated Primarily via Their α7-α7 Interfaces. Molecular Pharmacology, 81 (2). pp. 175-188. ISSN 0026-895X. PMCID PMC3263954. https://resolver.caltech.edu/CaltechAUTHORS:20120214-145000544

Cohen, B. N. and Mackey, E. D. W. and Grady, S. R. et al. (2012) Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior. Neuroscience, 200 . pp. 31-41. ISSN 0306-4522. PMCID PMC3249511. https://resolver.caltech.edu/CaltechAUTHORS:20120214-082915834

2011

Xiao, Cheng and Srinivasan, Rahul and Drenan, Ryan M. et al. (2011) Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: Mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells. Biochemical Pharmacology, 82 (8). pp. 852-861. ISSN 0006-2952. PMCID PMC3162078. https://resolver.caltech.edu/CaltechAUTHORS:20110922-073823540

Du, Jiangang and Blanche, Timothy J. and Harrison, Reid R. et al. (2011) Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes. PLoS ONE, 6 (10). Art. No. e26204. ISSN 1932-6203. PMCID PMC3192171/. https://resolver.caltech.edu/CaltechAUTHORS:20111111-102216534

Xu, J. and Cohen, B. N. and Zhu, Y. et al. (2011) Altered activity–rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor. Molecular Psychiatry, 16 (10). pp. 1048-1061. ISSN 1359-4184. PMCID PMC2970689. https://resolver.caltech.edu/CaltechAUTHORS:20111018-104112346

Van Arnam, Ethan B. and Lester, Henry A. and Dougherty, Dennis A. (2011) Dissecting the Functions of Conserved Prolines within Transmembrane Helices of the D2 Dopamine Receptor. ACS Chemical Biology, 6 (10). pp. 1063-1068. ISSN 1554-8929. PMCID PMC3199346. https://resolver.caltech.edu/CaltechAUTHORS:20111116-105837023

Lummis, S. C. R. and Thompson, A. J. and Bencherif, M. et al. (2011) Varenicline Is a Potent Agonist of the Human 5-Hydroxytryptamine_3 Receptor. Journal of Pharmacology and Experimental Therapeutics, 339 (1). pp. 125-131. ISSN 0022-3565. PMCID PMC3186289. https://resolver.caltech.edu/CaltechAUTHORS:20111028-122557103

Blum, Angela P. and Gleitsman, Kristin Rule and Lester, Henry A. et al. (2011) Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor: Role of the Vicinal Disulfide of the α1 Subunit. Journal of Biological Chemistry, 286 (37). pp. 32251-32258. ISSN 0021-9258. PMCID PMC3173184. https://resolver.caltech.edu/CaltechAUTHORS:20111004-120511603

Richards, Christopher I. and Srinivasan, Rahul and Xiao, Cheng et al. (2011) Trafficking of α4^* Nicotinic Receptors Revealed by Superecliptic Phluorin. Journal of Biological Chemistry, 286 (36). pp. 31241-31249. ISSN 0021-9258. PMCID PMC3173132. https://resolver.caltech.edu/CaltechAUTHORS:20110922-112958690

Puskar, Nyssa L. and Xiu, Xinan and Lester, Henry A. et al. (2011) Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes. Journal of Biological Chemistry, 286 (16). pp. 14618-14627. ISSN 0021-9258. PMCID PMC3077659. https://resolver.caltech.edu/CaltechAUTHORS:20110502-112328466

Miwa, Julie M. and Freedman, Robert and Lester, Henry A. (2011) Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses. Neuron, 70 (1). pp. 20-33. ISSN 0896-6273. PMCID PMC4418790. https://resolver.caltech.edu/CaltechAUTHORS:20110519-095350891

Pless, Stephan A. and Hanek, Ariele P. and Price, Kerry L. et al. (2011) A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists. Molecular Pharmacology, 79 (4). pp. 742-748. ISSN 0026-895X. PMCID PMC3063724. https://resolver.caltech.edu/CaltechAUTHORS:20110404-100247422

Srinivasan, Rahul and Pantoja, Rigo and Moss, Fraser J. et al. (2011) Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. Journal of General Physiology, 137 (1). pp. 59-79. ISSN 0022-1295. PMCID PMC3010053. https://resolver.caltech.edu/CaltechAUTHORS:20110208-094115987

Shanata, Jai A. P. and Frazier, Shawnalea J. and Lester, Henry A. et al. (2011) Using Mutant Cycle Analysis to Elucidate Long-Range Functional Coupling in Allosteric Receptors. In: Allostery: Methods and Protocols. Methods in Molecular Biology. No.796. Springer , pp. 97-113. ISBN 9781617793332. PMCID PMC4006985. https://resolver.caltech.edu/CaltechAUTHORS:20111114-081228635

2010

Thompson, Andrew J. and Lester, Henry A. and Lummis, Sarah C. R. (2010) The structural basis of function in Cys-loop receptors. Quarterly Reviews of Biophysics, 43 (4). pp. 449-499. ISSN 0033-5835. https://resolver.caltech.edu/CaltechAUTHORS:20101221-093346658

Blum, Angela P. and Lester, Henry A. and Dougherty, Dennis A. (2010) Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proceedings of the National Academy of Sciences of the United States of America, 107 (30). pp. 13206-13211. ISSN 0027-8424. PMCID PMC2922130. https://resolver.caltech.edu/CaltechAUTHORS:20100913-091409908

Drenan, Ryan M. and Grady, Sharon R. and Steele, Andrew D. et al. (2010) Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors. Journal of Neuroscience, 30 (29). pp. 9877-9889. ISSN 0270-6474. PMCID PMC3390922. https://resolver.caltech.edu/CaltechAUTHORS:20100811-085614377

Hanek, Ariele P. and Lester, Henry A. and Dougherty, Dennis A. (2010) Photochemical Proteolysis of an Unstructured Linker of the GABAAR Extracellular Domain Prevents GABA but Not Pentobarbital Activation. Molecular Pharmacology, 78 (1). pp. 29-35. ISSN 0026-895X. PMCID PMC2912059. https://resolver.caltech.edu/CaltechAUTHORS:20100709-141019159

Grady, Sharon R. and Drenan, Ryan M. and Breining, Scott R. et al. (2010) Structural differences determine the relative selectivity of nicotinic compounds for native α4β2^*-, α6β2^*-, α3β4^*- and α7-nicotine acetylcholine receptors. Neuropharmacology, 58 (7). pp. 1054-1066. ISSN 0028-3908. PMCID PMC2849849. https://resolver.caltech.edu/CaltechAUTHORS:20100604-114525877

Limapichat, Walrati and Lester, Henry A. and Dougherty, Dennis A. (2010) Chemical Scale Studies of the Phe-Pro Conserved Motif in the Cys Loop of Cys. Journal of Biological Chemistry, 285 (12). pp. 8976-8984. ISSN 0021-9258. PMCID PMC2838319. https://resolver.caltech.edu/CaltechAUTHORS:20100409-120603576

Zhao-Shea, Rubing and Cohen, Bruce N. and Just, Herwig et al. (2010) Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism. FASEB Journal, 24 (1). pp. 49-57. ISSN 0892-6638. PMCID PMC2797035. https://resolver.caltech.edu/CaltechAUTHORS:20100119-103312477

2009

Moss, Fraser J. and Imoukhuede, P. I. and Scott, Kimberly et al. (2009) GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET. Journal of General Physiology, 134 (6). pp. 489-521. ISSN 0022-1295. PMCID PMC2806419. https://resolver.caltech.edu/CaltechAUTHORS:20091218-122259894

Xiao, Cheng and Nashmi, Raad and McKinney, Sheri et al. (2009) Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway. Journal of Neuroscience, 29 (40). pp. 12428-12439. ISSN 0270-6474. PMCID PMC2787412. https://resolver.caltech.edu/CaltechAUTHORS:20091102-100009481

Pantoja, Rigo and Srinivasan, Rahul and Kadambi, Sindhuja et al. (2009) Pharmacological chaperoning of nicotinic receptors begins in the endoplasmic reticulum: High-resolution imaging. Biochemical Pharmacology, 78 (7). pp. 900-901. ISSN 0006-2952. https://resolver.caltech.edu/CaltechAUTHORS:20090916-091123236

Srinivasan, Rahul and Pantoja, Rigo and Kadambi, Sindhuja et al. (2009) Pharmacological chaperoning of nicotinic receptors begins in the endoplasmic reticulum: Compartments and stoichiometries. Biochemical Pharmacology, 78 (7). p. 900. ISSN 0006-2952. https://resolver.caltech.edu/CaltechAUTHORS:20090911-153603948

Breining, Scott R. and Bencherif, Merouane and Grady, Sharon R. et al. (2009) Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the α6 subtype. Bioorganic and Medicinal Chemistry Letters, 19 (15). pp. 4359-4363. ISSN 0960-894X. PMCID PMC6107347. https://resolver.caltech.edu/CaltechAUTHORS:20090730-103918926

Torrice, Michael M. and Bower, Kiowa S. and Lester, Henry A. et al. (2009) Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids. Proceedings of the National Academy of Sciences of the United States of America, 106 (29). pp. 11919-11924. ISSN 0027-8424. PMCID PMC2715518. https://resolver.caltech.edu/CaltechAUTHORS:20090901-141204665

Gleitsman, Kristin R. and Lester, Henry A. and Dougherty, Dennis A. (2009) Probing the role of backbone hydrogen bonding in a critical β sheet of the extracellular domain of a cys-loop receptor. ChemBioChem, 10 (8). pp. 1385-1391. ISSN 1439-4227. PMCID PMC2789490. https://resolver.caltech.edu/CaltechAUTHORS:20090805-085419387

Son, Cagdas D. and Moss, Fraser J. and Cohen, Bruce N. et al. (2009) Nicotine Normalizes Intracellular Subunit Stoichiometry of Nicotinic Receptors Carrying Mutations Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. Molecular Pharmacology, 75 (5). pp. 1137-1148. ISSN 0026-895X. PMCID PMC2672806. https://resolver.caltech.edu/CaltechAUTHORS:20090914-084414850

Gleitsman, Kristin R. and Shanata, Jai A. P. and Frazier, Shawnalea J. et al. (2009) Long-Range Coupling in an Allosteric Receptor Revealed by Mutant Cycle Analysis. Biophysical Journal, 96 (8). pp. 3168-3178. ISSN 0006-3495. PMCID PMC2718292. https://resolver.caltech.edu/CaltechAUTHORS:20090827-132541833

Imoukhuede, P. I. and Moss, Fraser J. and Michael, Darren J. et al. (2009) Ezrin Mediates Tethering of the γ-Aminobutyric Acid Transporter GAT1 to Actin Filaments Via a C-Terminal PDZ-Interacting Domain. Biophysical Journal, 96 (7). pp. 2949-2960. ISSN 0006-3495. PMCID PMC2711277. https://resolver.caltech.edu/CaltechAUTHORS:20090903-090332845

Xiu, Xinan and Puskar, Nyssa L. and Shanata, Jai A. P. et al. (2009) Nicotine binding to brain receptors requires a strong cation–π interaction. Nature, 458 (7237). pp. 534-537. ISSN 0028-0836. PMCID PMC2755585. https://resolver.caltech.edu/CaltechAUTHORS:20090422-090708342

Lester, Henry A. and Xiao, Cheng and Srinivasan, Rahul et al. (2009) Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery. AAPS Journal, 11 (1). pp. 167-177. ISSN 1550-7416. PMCID PMC2664890. https://resolver.caltech.edu/CaltechAUTHORS:20090707-084125313

Bohland, Jason and Wu, Caizhi and Barbas, Helen et al. (2009) A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Computational Biology, 5 (3). Art. No. e1000334. ISSN 1553-734X. PMCID PMC2655718. https://resolver.caltech.edu/CaltechAUTHORS:20090717-142050047

Pantoja, Rigo and Rodriguez, Erik A. and Dibas, Mohammed I. et al. (2009) Single-Molecule Imaging of a Fluorescent Unnatural Amino Acid Incorporated Into Nicotinic Receptors. Biophysical Journal, 96 (1). pp. 226-237. ISSN 0006-3495. PMCID PMC2710013. https://resolver.caltech.edu/CaltechAUTHORS:20090909-105237809

2008

Gleitsman, Kristin Rule and Kedrowski, Sean M. A. and Lester, Henry A. et al. (2008) An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating. Journal of Biological Chemistry, 283 (51). pp. 35638-35643. ISSN 0021-9258. PMCID PMC2602911. https://resolver.caltech.edu/CaltechAUTHORS:GLEjbc08

Pless, Stephan A. and Millen, Kat S. and Hanek, Ariele P. et al. (2008) A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue. Journal of Neuroscience, 28 (43). pp. 10937-10942. ISSN 0270-6474. PMCID PMC2649377. https://resolver.caltech.edu/CaltechAUTHORS:PLEjns08

Drenan, Ryan M. and Grady, Sharon R. and Whiteaker, Paul et al. (2008) In vivo activation of midbrain dopamine neurons via sensitized, high-affinity α6*nicotinic acetylcholine receptors. Neuron, 60 (1). pp. 123-136. ISSN 0896-6273. PMCID PMC2632732. https://resolver.caltech.edu/CaltechAUTHORS:DREn08

Hanek, Ariele P. and Lester, Henry A. and Dougherty, Dennis A. (2008) A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor. Journal of the American Chemical Society, 130 (40). pp. 13216-13218. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:HANjacs08

Fonck, Carlos and Nashmi, Raad and Salas, Ramiro et al. (2008) Demonstration of functional α4-containing nicotinic receptors in the medial habenula. Neuropharmacology, 56 (1). pp. 247-253. ISSN 0028-3908. PMCID PMC2645341. https://resolver.caltech.edu/CaltechAUTHORS:FONnp09

Price, Kerry L. and Bower, Kiowa S. and Thompson, Andrew J. et al. (2008) A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT_3 Receptor. Biochemistry, 47 (24). pp. 6370-6377. ISSN 0006-2960. PMCID PMC264937. https://resolver.caltech.edu/CaltechAUTHORS:20170201-090914461

Maurer, Joshua A. and Elmore, Donald E. and Clayton, Daniel et al. (2008) Confirming the Revised C-Terminal Domain of the MscL Crystal Structure. Biophysical Journal, 94 (12). pp. 4662-4667. ISSN 0006-3495. PMCID PMC2397327. https://resolver.caltech.edu/CaltechAUTHORS:20170409-064941478

Shao, Xuesi M. and Tan, Wenbin and Xiu, Joanne et al. (2008) α4* Nicotinic Receptors in preBotzinger Complex Mediate Cholinergic/Nicotinic Modulation of Respiratory Rhythm. Journal of Neuroscience, 28 (2). pp. 519-528. ISSN 0270-6474. PMCID PMC3477875. https://resolver.caltech.edu/CaltechAUTHORS:20200421-112849285

Drenan, Ryan M. and Nashmi, Raad and Imoukhuede, Princess et al. (2008) Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits. Molecular Pharmacology, 73 (1). pp. 27-41. ISSN 0026-895X. https://resolver.caltech.edu/CaltechAUTHORS:20200422-074016834

2007

Pless, Stephan A. and Dibas, Mohammed I. and Lester, Henry A. et al. (2007) Conformational variability of the glycine receptor M2 domain in response to activation by different agonists. Journal of Biological Chemistry, 282 (49). pp. 36057-36067. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:PLEjbc07

Tapper, Andrew R. and McKinney, Sheri L. and Marks, Michael J. et al. (2007) Nicotine responses in hypersensitive and knockout α4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice. Physiological Genomics, 31 (3). pp. 422-428. ISSN 1094-8341. https://resolver.caltech.edu/CaltechAUTHORS:20200424-071823168

Rodriguez, Erik A. and Lester, Henry A. and Dougherty, Dennis A. (2007) Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: Minimizing misacylation. RNA, 13 (10). pp. 1703-1714. ISSN 1355-8382. PMCID PMC1986802. https://resolver.caltech.edu/CaltechAUTHORS:20200415-144146916

Rodriguez, Erik A. and Lester, Henry A. and Dougherty, Dennis A. (2007) Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: Evaluating suppression efficiency. RNA, 13 (10). pp. 1715-1722. ISSN 1355-8382. PMCID PMC1986817. https://resolver.caltech.edu/CaltechAUTHORS:20200415-144744313

Teper, Yaroslav and Whyte, Douglas and Cahir, Elizabeth et al. (2007) Nicotine-Induced Dystonic Arousal Complex in a Mouse Line Harboring a Human Autosomal-Dominant Nocturnal Frontal Lobe Epilepsy Mutation. Journal of Neuroscience, 27 (38). pp. 10128-10142. ISSN 0270-6474. PMCID PMC6672658. https://resolver.caltech.edu/CaltechAUTHORS:20200422-080631596

Wang, Jinti and Lester, Henry A. and Dougherty, Dennis A. (2007) Establishing an Ion Pair Interaction in the Homomeric {rho}1 {gamma}-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway. Journal of Biological Chemistry, 282 (36). pp. 26210-26216. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:WANjbc07

Jankowsky, Joanna L. and Younkin, Linda H. and Gonzales, Victoria et al. (2007) Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice. Journal of Biological Chemistry, 282 (31). pp. 22707-22720. ISSN 0021-9258. PMCID PMC4435736. https://resolver.caltech.edu/CaltechAUTHORS:JANjbc07

Nashmi, Raad and Xiao, Cheng and Deshpande, Purnima et al. (2007) Chronic Nicotine Cell Specifically Upregulates Functional α4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path. Journal of Neuroscience, 27 (31). pp. 8202-8218. ISSN 0270-6474. PMCID PMC6673074. https://resolver.caltech.edu/CaltechAUTHORS:20190905-080227761

Damaj, M. I. and Fonck, C. and Marks, M. J. et al. (2007) Genetic Approaches Identify Differential Roles for α₄β₂* Nicotinic Receptors in Acute Models of Antinociception in Mice. Journal of Pharmacology and Experimental Therapeutics, 321 (3). pp. 1161-1169. ISSN 0022-3565. https://resolver.caltech.edu/CaltechAUTHORS:20200427-083757686

Lerchner, Walter and Xiao, Cheng and Nashmi, Raad et al. (2007) Reversible Silencing of Neuronal Excitability in Behaving Mice by a Genetically Targeted, Ivermectin-Gated Cl^− Channel. Neuron, 54 (1). pp. 35-49. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20150305-114442340

Padgett, Claire L. and Hanek, Ariele P. and Lester, Henry A. et al. (2007) Unnatural Amino Acid Mutagenesis of the GABA_A Receptor Binding Site Residues Reveals a Novel Cation-π Interaction between GABA and β₂Tyr97. Journal of Neuroscience, 27 (4). pp. 886-892. ISSN 0270-6474. PMCID PMC2649369. https://resolver.caltech.edu/CaltechAUTHORS:20200416-150305764

Cashin, Amanda L. and Torrice, Michael M. and McMenimen, Kathryn A. et al. (2007) Chemical-Scale Studies on the Role of a Conserved Aspartate in Preorganizing the Agonist Binding Site of the Nicotinic Acetylcholine Receptor. Biochemistry, 46 (3). pp. 630-639. ISSN 0006-2960. PMCID PMC3164877. https://resolver.caltech.edu/CaltechAUTHORS:20170131-102250754

2006

Ahern, Christopher A. and Eastwood, Amy L. and Lester, Henry A. et al. (2006) A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels. Journal of General Physiology, 128 (6). pp. 649-657. ISSN 0022-1295. PMCID PMC2151593. https://resolver.caltech.edu/CaltechAUTHORS:AHEjgp06

Miwa, Julie M. and Stevens, Tanya R. and King, Sarah L. et al. (2006) The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo. Neuron, 51 (5). pp. 587-600. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20200427-095213669

Rodriguez, Erik A. and Lester, Henry A. and Dougherty, Dennis A. (2006) In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression. Proceedings of the National Academy of Sciences of the United States of America, 103 (23). pp. 8650-8655. ISSN 0027-8424. PMCID PMC1482635. https://resolver.caltech.edu/CaltechAUTHORS:RODpnas06

Schwarz, Johannes and Schwarz, Sigrid C. and Dorigo, Oliver et al. (2006) Enhanced expression of hypersensitive α4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons. FASEB Journal, 20 (7). pp. 935-946. ISSN 0892-6638. doi:10.1096/fj.05-5497com. https://resolver.caltech.edu/CaltechAUTHORS:20170408-135451181

McMenimen, Kathryn A. and Petersson, E. James and Lester, Henry A. et al. (2006) Probing the Mg^(2+) Blockade Site of an N-Methyl-d-aspartate (NMDA) Receptor with Unnatural Amino Acid Mutagenesis. ACS Chemical Biology, 1 (4). pp. 227-234. ISSN 1554-8929. https://resolver.caltech.edu/CaltechAUTHORS:20170201-140122486

Sokolova, Irina V. and Lester, Henry A. and Davidson, Norman (2006) Postsynaptic Mechanisms Are Essential for Forskolin-Induced Potentiation of Synaptic Transmission. Journal of Neurophysiology, 95 (4). pp. 2570-2579. ISSN 0022-3077. https://resolver.caltech.edu/CaltechAUTHORS:20200427-123125281

Nashmi, Raad and Lester, Henry A. (2006) CNS Localization of Neuronal Nicotinic Receptors. Journal of Molecular Neuroscience, 30 (1-2). pp. 181-184. ISSN 0895-8696. https://resolver.caltech.edu/CaltechAUTHORS:20110209-113037940

Nashmi, Raad and Lester, Henry A. (2006) CNS Localization of Neuronal Nicotinic Receptors. Journal of Molecular Neuroscience, 30 (1-2). pp. 181-184. ISSN 0895-8696. https://resolver.caltech.edu/CaltechAUTHORS:20200427-134509446

2005

Xiu, Xinan and Hanek, Ariele P. and Wang, Jinti et al. (2005) A Unified View of the Role of Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors. Journal of Biological Chemistry, 280 (50). pp. 41655-41666. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:XIUjbc05

Fonck, Carlos and Cohen, Bruce N. and Nashmi, Raad et al. (2005) Novel Seizure Phenotype and Sleep Disruptions in Knock-In Mice with Hypersensitive α4* Nicotinic Receptors. Journal of Neuroscience, 25 (49). pp. 11396-11411. ISSN 0270-6474. PMCID PMC6725918. https://resolver.caltech.edu/CaltechAUTHORS:20200427-144703784

Jankowsky, Joanna L. and Slunt, Hilda H. and Gonzales, Victoria et al. (2005) Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease. PLoS Medicine, 2 (12). Art. No. e355. ISSN 1549-1676. PMCID PMC1283364. https://resolver.caltech.edu/CaltechAUTHORS:JANplosmed05

Lummis, Sarah C. R. and Beene, Darren L. and Lee, Lori W. et al. (2005) Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature, 438 (4065). pp. 248-252. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150319-085128410

Lummis, Sarah C. R. and Beene, Darren L. and Harrison, Neil J. et al. (2005) A Cation-π Binding Interaction with a Tyrosine in the Binding Site of the GABA_C Receptor. Chemistry and Biology, 12 (9). pp. 993-997. ISSN 1074-5521. https://resolver.caltech.edu/CaltechAUTHORS:20200424-080629607

Rodrigues-Pinguet, Nivalda O. and Pinguet, Thierry J. and Figl, Antonio et al. (2005) Mutations Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Affect Allosteric Ca²⁺ Activation of the α4β2 Nicotinic Acetylcholine Receptor. Molecular Pharmacology, 68 (2). pp. 487-501. ISSN 0026-895X. https://resolver.caltech.edu/CaltechAUTHORS:20200428-121436325

Khakh, Baljit S. and Fisher, James A. and Nashmi, Raad et al. (2005) An Angstrom Scale Interaction between Plasma Membrane ATP-Gated P2X₂ and α₄β₂ Nicotinic Channels Measured with Fluorescence Resonance Energy Transfer and Total Internal Reflection Fluorescence Microscopy. Journal of Neuroscience, 25 (29). pp. 6911-6920. ISSN 0270-6474. PMCID PMC6725363. https://resolver.caltech.edu/CaltechAUTHORS:20200417-142718484

Chiu, Chi-Sung and Brickley, Stephen and Jensen, Kimmo et al. (2005) GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum. Journal of Neuroscience, 25 (12). pp. 3234-3245. ISSN 0270-6474. PMCID PMC6725086. https://resolver.caltech.edu/CaltechAUTHORS:20200506-072848149

Kovoor, Abraham and Seyffarth, Petra and Ebert, Jana et al. (2005) D₂ Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways. Journal of Neuroscience, 25 (8). pp. 2157-2165. ISSN 0270-6474. PMCID PMC6726050. https://resolver.caltech.edu/CaltechAUTHORS:20200506-074200832

Cashin, Amanda L. and Petersson, E. James and Lester, Henry A. et al. (2005) Using Physical Chemistry To Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine Receptor. Journal of the American Chemical Society, 127 (1). pp. 350-356. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20170425-083958251

2004

Tapper, Andrew R. and McKinney, Sheri L. and Nashmi, Raad et al. (2004) Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization. Science, 306 (5698). pp. 1029-1032. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141119-090016448

Diba, Kamran and Lester, Henry A. and Koch, Christof (2004) Intrinsic Noise in Cultured Hippocampal Neurons: Experiment and Modeling. Journal of Neuroscience, 24 (43). pp. 9723-9733. ISSN 0270-6474. PMCID PMC6730144. https://resolver.caltech.edu/CaltechAUTHORS:20130816-103138809

Beene, Darren L. and Price, Kerry L. and Lester, Henry A. et al. (2004) Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine₃ Receptor Revealed by Unnatural Amino Acid Mutagenesis. Journal of Neuroscience, 24 (41). pp. 9097-9104. ISSN 0270-6474. PMCID PMC6730062. https://resolver.caltech.edu/CaltechAUTHORS:20200427-084524229

Becker, Christian F. W. and Clayton, Daniel and Shapovalov, George et al. (2004) On-Resin Assembly of a Linkerless Lanthanide(III)-Based Luminescence Label and Its Application to the Total Synthesis of Site-Specifically Labeled Mechanosensitive Channels. Bioconjugate Chemistry, 15 (5). pp. 1118-1124. ISSN 1043-1802. https://resolver.caltech.edu/CaltechAUTHORS:20170131-075938701

Orb, Sabine and Wieacker, Johannes and Labarca, Cesar et al. (2004) Knockin mice with Leu9′Ser α4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally. Physiological Genomics, 18 (3). pp. 299-307. ISSN 1094-8341. https://resolver.caltech.edu/CaltechAUTHORS:20200422-150959788

Shapalov, George and Lester, Henry A. (2004) Gating Transitions in Bacterial Ion Channels Measured at 3 µs Resolution. Journal of General Physiology, 124 (2). pp. 151-161. ISSN 0022-1295. PMCID PMC2229625. https://resolver.caltech.edu/CaltechAUTHORS:SHAjgp04

Dahan, David S. and Dibas, Mohammed I. and Petersson, E. James et al. (2004) A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site. Proceedings of the National Academy of Sciences of the United States of America, 101 (27). pp. 10195-10200. ISSN 0027-8424. PMCID PMC454187. https://resolver.caltech.edu/CaltechAUTHORS:DAHpnas04

Bhattacharya, Anindya and Dang, Hong and Zhu, Quan-Ming et al. (2004) Uropathic Observations in Mice Expressing a Constitutively Active Point Mutation in the 5-HT_(3A) Receptor Subunit. Journal of Neuroscience, 24 (24). pp. 5537-5548. ISSN 0270-6474. PMCID PMC6729324. https://resolver.caltech.edu/CaltechAUTHORS:20200513-072838651

Lester, Henry A. and Dibas, Mohammed I. and Dahan, David S. et al. (2004) Cys-loop receptors: new twists and turns. Trends in Neurosciences, 27 (6). pp. 329-336. ISSN 0166-2236. https://resolver.caltech.edu/CaltechAUTHORS:20200427-094708016

Clayton, Daniel and Shapovalov, George and Maurer, Joshua A. et al. (2004) Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America, 101 (14). pp. 4764-4769. ISSN 0027-8424. PMCID PMC387322. https://resolver.caltech.edu/CaltechAUTHORS:CLApnas04

2003

Nashmi, Raad and Dickinson, Mary E. and McKinney, Sheri et al. (2003) Assembly of α4β2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons. Journal of Neuroscience, 23 (37). pp. 11554-11567. ISSN 0270-6474. PMCID PMC6740951. https://resolver.caltech.edu/CaltechAUTHORS:20160212-092320526

Gutman, George A. and Lester, Henry A. (2003) International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels. Pharmacological Reviews, 55 (4). pp. 583-586. ISSN 0031-6997. https://resolver.caltech.edu/CaltechAUTHORS:20180313-125205786

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Leite, John F. and Blanton, Michael P. and Shahgholi, Mona et al. (2003) Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: Electrophysiology-coordinated photochemistry and mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America, 100 (22). pp. 13054-13059. ISSN 0027-8424. PMCID PMC240743. https://resolver.caltech.edu/CaltechAUTHORS:LEIpnas03

Storch, Alexander and Lester, Henry A. and Boehm, Bernhard O. et al. (2003) Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells. Journal of Chemical Neuroanatomy, 26 (2). pp. 133-142. ISSN 0891-0618. https://resolver.caltech.edu/CaltechAUTHORS:20200427-151732404

Jensen, Kimmo and Chiu, Chi-Sung and Sokolova, Irina et al. (2003) GABA Transporter-1 (GAT1)-Deficient Mice: Differential Tonic Activation of GABA_A Versus GABA_B Receptors in the Hippocampus. Journal of Neurophysiology, 90 (4). pp. 2690-2701. ISSN 0022-3077. https://resolver.caltech.edu/CaltechAUTHORS:20200428-095147178

Lester, Henry A. and Fonck, Carlos and Tapper, Andrew R. et al. (2003) Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action. Current opinion in drug discovery & development, 6 (5). pp. 633-639. ISSN 1367-6733. https://resolver.caltech.edu/CaltechAUTHORS:20200428-093705406

Leite, John F. and Dougherty, Dennis A. and Lester, Henry A. et al. (2003) Investigation of apparent mass deviations in electrospray ionization tandem mass spectrometry of a benzophenone-labeled peptide. Rapid Communications in Mass Spectrometry, 17 (15). pp. 1677-1684. ISSN 0951-4198. https://resolver.caltech.edu/CaltechAUTHORS:20200417-142717107

Rodrigues-Pinguet, Nivalda and Jia, Li and Li, Maureen et al. (2003) Five ADNFLE Mutations Reduce the Ca²⁺ Dependence of the Mammalian α4β2 Acetylcholine Response. Journal of Physiology, 550 (1). pp. 11-26. ISSN 0022-3751. PMCID PMC2343021. https://resolver.caltech.edu/CaltechAUTHORS:20200428-095147285

Yu, Tzu-ping and Lester, Henry A. and Davidson, Norman (2003) Requirement of a critical period of GABAergic receptor blockade for induction of a cAMP-mediated long-term depression at CA3-CA1 synapses. Synapse, 49 (1). pp. 12-19. ISSN 0887-4476. https://resolver.caltech.edu/CaltechAUTHORS:20200515-112555466

Rahman, Zia and Schwarz, Johannes and Gold, Stephen J. et al. (2003) RGS9 Modulates Dopamine Signaling in the Basal Ganglia. Neuron, 38 (6). pp. 941-952. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20200515-125021148

Mu, Ting-Wei and Lester, Henry A. and Dougherty, Dennis A. (2003) Different Binding Orientations for the Same Agonist at Homologous Receptors: A Lock and Key or a Simple Wedge? Journal of the American Chemical Society, 125 (23). pp. 6850-6851. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20170510-080843497

Monahan, Sarah L. and Lester, Henry A. and Dougherty, Dennis A. (2003) Site-Specific Incorporation of Unnatural Amino Acids into Receptors Expressed in Mammalian Cells. Chemistry and Biology, 10 (6). pp. 573-580. ISSN 1074-5521. https://resolver.caltech.edu/CaltechAUTHORS:20200427-134043259

Beene, Darren L. and Dougherty, Dennis A. and Lester, Henry A. (2003) Unnatural amino acid mutagenesis in mapping ion channel function. Current Opinion in Neurobiology, 13 (3). pp. 264-270. ISSN 0959-4388. https://resolver.caltech.edu/CaltechAUTHORS:20200427-123619296

Fonck, Carlos and Nashmi, Raad and Deshpande, Purnima et al. (2003) Increased Sensitivity to Agonist-Induced Seizures, Straub Tail, and Hippocampal Theta Rhythm in Knock-In Mice Carrying Hypersensitive α4 Nicotinic Receptors. Journal of Neuroscience, 23 (7). pp. 2582-2590. ISSN 0270-6474. PMCID PMC6742094. https://resolver.caltech.edu/CaltechAUTHORS:20190927-090347351

Shapovalov, George and Bass, Randal and Rees, Douglas C. et al. (2003) Open-State Disulfide Crosslinking between Mycobacterium tuberculosis Mechanosensitive Channel Subunits. Biophysical Journal, 84 (4). pp. 2357-2365. ISSN 0006-3495. PMCID PMC1302802. https://resolver.caltech.edu/CaltechAUTHORS:20141212-145345633

Slimko, Eric M. and Lester, Henry A. (2003) Codon optimization of Caenorhabditis elegans GluCl ion channel genes for mammalian cells dramatically improves expression levels. Journal of Neuroscience Methods, 124 (1). pp. 75-81. ISSN 0165-0270. https://resolver.caltech.edu/CaltechAUTHORS:20200626-123755093

Rozengurt, Nora and Lopez, Ivan and Chiu, Chi-Sung et al. (2003) Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit. Hearing Research, 177 (1-2). pp. 71-80. ISSN 0378-5955. https://resolver.caltech.edu/CaltechAUTHORS:20200612-075804212

Leite, John F. and Rodrigues-Pinguet, Nivalda and Lester, Henry A. (2003) Insights into channel function via channel dysfunction. Journal of Clinical Investigation, 111 (4). pp. 436-437. ISSN 0021-9738. PMCID PMC151932. https://resolver.caltech.edu/CaltechAUTHORS:20111011-100601324

Petersson, E. James and Brandt, Gabriel S. and Zacharias, Niki M. et al. (2003) Caging proteins through unnatural amino acids mutagenesis. In: Biophotonics, Part A. Methods in Enzymology. No.360. Academic Press , San Diego, CA, pp. 258-273. ISBN 9780121822637. https://resolver.caltech.edu/CaltechAUTHORS:20200417-142717296

2002

Chiu, Chi-Sung and Jensen, Kimmo and Sokolova, Irina et al. (2002) Number, Density, and Surface/Cytoplasmic Distribution of GABA Transporters at Presynaptic Structures of Knock-In Mice Carrying GABA Transporter Subtype 1–Green Fluorescent Protein Fusions. Journal of Neuroscience, 22 (23). pp. 10251-10266. ISSN 0270-6474. PMCID PMC6758747. https://resolver.caltech.edu/CaltechAUTHORS:20190930-133756603

Petersson, E. James and Choi, Anita and Dahan, David S. et al. (2002) A Perturbed pK_a at the Binding Site of the Nicotinic Acetylcholine Receptor: Implications for Nicotine Binding. Journal of the American Chemical Society, 124 (43). pp. 12662-12663. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20170414-144546207

Li, Ping and Slimko, Eric M. and Lester, Henry A. (2002) Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel. FEBS Letters, 528 (1-3). pp. 77-82. ISSN 0014-5793. https://resolver.caltech.edu/CaltechAUTHORS:20200612-113333592

Slimko, Eric M. and McKinney, Sheri and Anderson, David J. et al. (2002) Selective Electrical Silencing of Mammalian Neurons In Vitro by the Use of Invertebrate Ligand-Gated Chloride Channels. Journal of Neuroscience, 22 (17). pp. 7373-7379. ISSN 0270-6474. PMCID PMC6757961. https://resolver.caltech.edu/CaltechAUTHORS:20150303-122051974

Beene, Darren L. and Brandt, Gabriel S. and Zhong, Wenge et al. (2002) Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT_(3A)) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine. Biochemistry, 41 (32). pp. 10262-10269. ISSN 0006-2960. https://resolver.caltech.edu/CaltechAUTHORS:20170125-110549324

Eickhorst, Angela N. and Berson, Amy and Cockayne, Debra et al. (2002) Control of P2X2 Channel Permeability by the Cytosolic Domain. Journal of General Physiology, 120 (2). pp. 119-131. ISSN 0022-1295. PMCID PMC2234464. https://resolver.caltech.edu/CaltechAUTHORS:EICjgp02

Li, Ming and Lester, Henry A. (2002) Early Fluorescence Signals Detect Transitions at Mammalian Serotonin Transporters. Biophysical Journal, 83 (1). pp. 206-218. ISSN 0006-3495. PMCID PMC1302140. https://resolver.caltech.edu/CaltechAUTHORS:20200612-113333889

Nadeau, H. and Lester, H. A. (2002) NRSF Causes cAMP-Sensitive Suppression of Sodium Current in Cultured Hippocampal Neurons. Journal of Neurophysiology, 88 (1). pp. 409-421. ISSN 0022-3077. https://resolver.caltech.edu/CaltechAUTHORS:20200612-113333802

Petersson, E. J. and Shahgholi, M. and Lester, H. A. et al. (2002) MALDI-TOF mass spectrometry methods for evaluation of in vitro aminoacyl tRNA production. RNA, 8 (4). pp. 542-547. ISSN 1355-8382. PMCID PMC1370275. https://resolver.caltech.edu/CaltechAUTHORS:PETrnao02

Li, Ming and Farley, Robert A. and Lester, Henry A. (2002) Voltage-dependent transient currents of human and rat 5-HT transporters (SERT) are blocked by HEPES and ion channel ligands. FEBS Letters, 513 (2-3). pp. 247-252. ISSN 0014-5793. https://resolver.caltech.edu/CaltechAUTHORS:20200612-113333997

Kovoor, Abraham and Lester, Henry A. (2002) Gi Irks GIRKs. Neuron, 33 (1). pp. 6-8. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20200612-113334102

2001

Neusch, Clemens and Rozengurt, Nora and Jacobs, Russell E. et al. (2001) Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination. Journal of Neuroscience, 21 (15). pp. 5429-5438. ISSN 0270-6474. PMCID PMC6762664. https://resolver.caltech.edu/CaltechAUTHORS:20160210-145519981

Philipson, Kenneth D. and Gallivan, Justin P. and Brandt, Gabriel S. et al. (2001) Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor. American Journal of Physiology. Cell Physiology, 281 (1). C195-C206. ISSN 0363-6143. https://resolver.caltech.edu/CaltechAUTHORS:20200506-103644435

Li, Ming and Lester, Henry A. (2001) Ion Channel Diseases of the Central Nervous System. CNS Drug Reviews, 7 (2). pp. 214-240. ISSN 1080-563X. PMCID PMC6741647. https://resolver.caltech.edu/CaltechAUTHORS:20200612-115646273

Dougherty, Dennis A. and Lester, Henry A. (2001) Neurobiology: Snails, synapses and smokers. Nature, 411 (6835). pp. 252-254. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150327-103308333

Khakh, Baljit S. and Smith, W. Bryan and Chiu, Chi-Sung et al. (2001) Activation-dependent changes in receptor distribution and dendritic morphology in hippocampal neurons expressing P2X(2)-green fluorescent protein receptors. Proceedings of the National Academy of Sciences of the United States of America, 98 (9). pp. 5288-5293. ISSN 0027-8424. PMCID PMC33202. https://resolver.caltech.edu/CaltechAUTHORS:KHApnas01a

Yu, Tzu-ping and McKinney, Sheri and Lester, Henry A. et al. (2001) gamma-Aminobutyric acid type A receptors modulate cAMP-mediated long-term potentiation and long-term depression at monosynaptic CA3-CA1 synapses. Proceedings of the National Academy of Sciences of the United States of America, 98 (9). pp. 5264-5269. ISSN 0027-8424. PMCID PMC33198. https://resolver.caltech.edu/CaltechAUTHORS:YUTpnas01

Labarca, Cesar and Schwarz, Johannes and Deshpande, Purnima et al. (2001) Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proceedings of the National Academy of Sciences of the United States of America, 98 (5). pp. 2786-2791. ISSN 0027-8424. PMCID PMC30217. https://resolver.caltech.edu/CaltechAUTHORS:LABpnas01

Tong, Yanhe and Brandt, Gabriel S. and Li, Ming et al. (2001) Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel. Journal of General Physiology, 117 (2). pp. 103-118. ISSN 0022-1295. PMCID PMC2217249. https://resolver.caltech.edu/CaltechAUTHORS:TONjgp01

Chiu, Chi-Sung and Kartalov, Emil and Unger, Marc et al. (2001) Single-molecule measurements calibrate green fluorescent protein surface densities on transparent beads for use with ‘knock-in’ animals and other expression systems. Journal of Neuroscience Methods, 105 (1). pp. 55-63. ISSN 0165-0270. https://resolver.caltech.edu/CaltechAUTHORS:20200612-115646402

Li, Lintong and Zhong, Wenge and Zacharias, Niki et al. (2001) The tethered agonist approach to mapping ion channel proteins – toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor. Chemistry and Biology, 8 (1). pp. 47-58. ISSN 1074-5521. https://resolver.caltech.edu/CaltechAUTHORS:20200422-150959147

2000

Chiu, Chi-Sung and Ross, Linda S. and Cohen, Bruce N. et al. (2000) The transporter-like protein inebriated mediates hyperosmotic stimuli through intracellular signaling. Journal of Experimental Biology, 203 (23). pp. 3531-3546. ISSN 0022-0949. https://resolver.caltech.edu/CaltechAUTHORS:CHIjeb00

Ehrengruber, Markus U. and Muhlebach, Stephan G. and Söhrman, Sophia et al. (2000) Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus. Gene, 258 (1-2). pp. 63-69. ISSN 0378-1119. https://resolver.caltech.edu/CaltechAUTHORS:20200612-115646596

Kofuji, Paulo and Ceelen, Paul and Zahs, Kathleen R. et al. (2000) Genetic Inactivation of an Inwardly Rectifying Potassium Channel (Kir4.1 Subunit) in Mice: Phenotypic Impact in Retina. Journal of Neuroscience, 20 (15). pp. 5733-5740. ISSN 0270-6474. PMCID PMC2410027. https://resolver.caltech.edu/CaltechAUTHORS:20200612-132259782

Nadeau, H. and Mckinney, S. and Anderson, D. J. et al. (2000) ROMK1 (Kir1.1) Causes Apoptosis and Chronic Silencing of Hippocampal Neurons. Journal of Neurophysiology, 84 (2). pp. 1062-1075. ISSN 0022-3077. https://resolver.caltech.edu/CaltechAUTHORS:20150306-095241138

Khakh, Baljit S. and Zhou, Xiaoping and Sydes, Jason et al. (2000) State-dependent cross-inhibition between transmitter-gated cation channels. Nature, 406 (6794). pp. 405-410. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150327-133158044

Maurer, Joshua A. and Elmore, Donald E. and Lester, Henry A. et al. (2000) Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL) - New gain of function mutations in the loop region. Journal of Biological Chemistry, 275 (29). pp. 22238-22244. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:MAUjbc00

Nadeau, H. and Lester, H. A. (2000) Two-compartment model for whole-cell data analysis and transient compensation. Journal of Neuroscience Methods, 99 (1-2). pp. 25-35. ISSN 0165-0270. https://resolver.caltech.edu/CaltechAUTHORS:20181213-110051972

Dang, Hong and England, Pamela M. and Farivar, S. Sarah et al. (2000) Probing the Role of a Conserved M1 Proline Residue in 5-Hydroxytryptamine₃ Receptor Gating. Molecular Pharmacology, 57 (6). pp. 1114-1122. ISSN 0026-895X. https://resolver.caltech.edu/CaltechAUTHORS:20200513-070503095

Li, Ming and Farley, Robert A. and Lester, Henry A. (2000) An Intermediate State of the {gamma}-Aminobutyric Acid Transporter GAT1 Revealed by Simultaneous Voltage Clamp and Fluorescence. Journal of General Physiology, 115 (4). pp. 491-508. ISSN 0022-1295. PMCID PMC2233755. https://resolver.caltech.edu/CaltechAUTHORS:LIMjgp00

Lester, Henry A. and Karschin, Andreas (2000) Gain of function mutants: Ion channels and G protein-coupled receptors. Annual Review of Neuroscience, 23 . pp. 89-125. ISSN 0147-006X. https://resolver.caltech.edu/CaltechAUTHORS:LESarn00

Kovoor, Abraham and Chen, Ching-Kang and He, Wei et al. (2000) Co-expression of Gbeta 5 Enhances the Function of Two Ggamma Subunit-like Domain-containing Regulators of G Protein Signaling Proteins. Journal of Biological Chemistry, 275 (5). pp. 3397-3402. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:KOVjbc00

Ivanina, Tatiana and Neusch, Clemens and Li, Yong-Xin et al. (2000) Expression of GIRK (Kir3.1/Kir3.4) channels in mouse fibroblast cells with and without β1 integrins. FEBS Letters, 466 (2-3). pp. 327-332. ISSN 0014-5793. https://resolver.caltech.edu/CaltechAUTHORS:20200612-132259910

1999

Unger, M. and Kartalov, E. and Chiu, C.-S. et al. (1999) Single-Molecule Fluorescence Observed with Mercury Lamp Illumination. BioTechniques, 27 (5). pp. 1008-1014. ISSN 0736-6205. https://resolver.caltech.edu/CaltechAUTHORS:20200612-132300221

England, Pamela M. and Lester, Henry A. and Dougherty, Dennis A. (1999) Mapping Disulfide Connectivity Using Backbone Ester Hydrolysis. Biochemistry, 38 (43). pp. 14409-14415. ISSN 0006-2960. https://resolver.caltech.edu/CaltechAUTHORS:20180313-080855191

Khakh, Baljit S. and Proctor, William R. and Dunwiddie, Thomas V. et al. (1999) Allosteric Control of Gating and Kinetics at P2X₄ Receptor Channels. Journal of Neuroscience, 19 (17). pp. 7289-7299. ISSN 0270-6474. PMCID PMC6782529. https://resolver.caltech.edu/CaltechAUTHORS:20191028-115507054

Khakh, Baljit S. and Lester, Henry A. (1999) Dynamic Selectivity Filters in Ion Channels. Neuron, 23 (4). pp. 653-658. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20200626-123754307

Li, Jun and Lester, Henry A. (1999) Functional roles of aromatic residues in the ligand-binding domain of cyclic nucleotide-gated channels. Molecular Pharmacology, 55 (5). pp. 873-882. ISSN 0026-895X. https://resolver.caltech.edu/CaltechAUTHORS:20200626-123655847

Li, Jun and Lester, Henry A. (1999) Single-channel kinetics of the rat olfactory cyclic nucleotide-gated channel expressed in Xenopus oocytes. Molecular Pharmacology, 55 (5). pp. 883-893. ISSN 0026-895X. https://resolver.caltech.edu/CaltechAUTHORS:20200626-123656741

Khakh, Baljit S. and Bao, Xiaoyan R. and Labarca, Cesar et al. (1999) Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nature Neuroscience, 2 (4). pp. 322-330. ISSN 1097-6256. https://resolver.caltech.edu/CaltechAUTHORS:20150414-095506624

England, Pamela M. and Zhang, Yinong and Dougherty, Dennis A. et al. (1999) Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel: Implications for the Mechanism of Gating. Cell, 96 (1). pp. 89-98. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20200514-152725398

1998

McPhee, Jancy C. and Dang, Yan L. and Davidson, Norman et al. (1998) Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels. Journal of Biological Chemistry, 273 (52). pp. 34696-34702. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:MCPjbc98

Zhong, Wenge and Gallivan, Justin P. and Zhang, Yinong et al. (1998) From ab initio quantum mechanics to molecular neurobiology: A cation-pi binding site in the nicotinic receptor. Proceedings of the National Academy of Sciences of the United States of America, 95 (21). pp. 12088-12093. ISSN 0027-8424. PMCID PMC22789. https://resolver.caltech.edu/CaltechAUTHORS:ZHPpnas98

Dougherty, Dennis A. and Lester, Henry A. (1998) The Crystal Structure of a Potassium Channel — A New Era in the Chemistry of Biological Signaling. Angewandte Chemie International Edition, 37 (17). pp. 2329-2331. ISSN 1433-7851. https://resolver.caltech.edu/CaltechAUTHORS:20180508-083019710

Li, Yong-Xin and Xu, Youfeng and Ju, Donghong et al. (1998) Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America, 95 (18). pp. 10884-10889. ISSN 0027-8424. PMCID PMC27990. https://resolver.caltech.edu/CaltechAUTHORS:LIYpnas98

Silverman, Scott K. and Lester, Henry A. and Dougherty, Dennis A. (1998) Asymmetrical Contributions of Subunit Pore Regions to Ion Selectivity in an Inward Rectifier K⁺ Channel. Biophysical Journal, 75 (3). pp. 1330-1339. ISSN 0006-3495. PMCID PMC1299807. https://resolver.caltech.edu/CaltechAUTHORS:20200513-104033054

Miller, Jeffrey C. and Silverman, Scott K. and England, Pamela M. et al. (1998) Flash Decaging of Tyrosine Sidechains in an Ion Channel. Neuron, 20 (4). pp. 619-624. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20200515-132054818

Lester, Henry A. and Dougherty, Dennis A. (1998) New Views of Multi-Ion Channels. Journal of General Physiology, 111 (2). pp. 181-183. ISSN 0022-1295. PMCID PMC2222761. https://resolver.caltech.edu/CaltechAUTHORS:LESjgp98

Nowak, Mark W. and Gallivan, Justin P. and Silverman, Scott K. et al. (1998) In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system. In: Ion Channels Part B. Methods in Enzymology. No.293. Academic Press , San Diego, CA, pp. 504-529. ISBN 978-0-12-182194-4. https://resolver.caltech.edu/CaltechAUTHORS:20200515-134619162

1997

West, Anthony P., Jr. and Bjorkman, Pamela J. and Dougherty, Dennis A. et al. (1997) Expression and Circular Dichroism Studies of the Extracellular Domain of the alpha Subunit of the Nicotinic Acetylcholine Receptor. Journal of Biological Chemistry, 272 (41). pp. 25468-25473. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:WESjbc97

Gallivan, Justin P. and Lester, Henry A. and Dougherty, Dennis A. (1997) Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins. Chemistry and Biology, 4 (10). pp. 739-749. ISSN 1074-5521. https://resolver.caltech.edu/CaltechAUTHORS:20200515-142830762

England, Pamela M. and Lester, Henry A. and Davidson, Norman et al. (1997) Site-specific, photochemical proteolysis applied to ion channels in vivo. Proceedings of the National Academy of Sciences of the United States of America, 94 (20). pp. 11025-11030. ISSN 0027-8424. PMCID PMC23572. https://resolver.caltech.edu/CaltechAUTHORS:ENGpnas97

Doupnik, Craig A. and Davidson, Norman and Lester, Henry A. et al. (1997) RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K^+ channels. Proceedings of the National Academy of Sciences of the United States of America, 94 (19). pp. 10461-10466. ISSN 0027-8424. PMCID PMC23385. https://resolver.caltech.edu/CaltechAUTHORS:DOUpnas97

Ehrengruber, Markus U. and Doupnik, Craig A. and Xu, Youfeng et al. (1997) Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America, 94 (13). pp. 7070-7075. ISSN 0027-8424. PMCID PMC21286. https://resolver.caltech.edu/CaltechAUTHORS:EHRpnas97

Quick, Michael W. and Corey, Janis L. and Davidson, Norman et al. (1997) Second Messengers, Trafficking-Related Proteins, and Amino Acid Residues that Contribute to the Functional Regulation of the Rat Brain GABA Transporter GAT1. Journal of Neuroscience, 17 (9). pp. 2967-2979. ISSN 0270-6474. PMCID PMC6573650. https://resolver.caltech.edu/CaltechAUTHORS:20191030-140944005

Li, Jun and Zagotta, William N. and Lester, Henry A. (1997) Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation. Quarterly Reviews of Biophysics, 30 (2). pp. 177-193. ISSN 0033-5835. https://resolver.caltech.edu/CaltechAUTHORS:LIJqrb97

Cao, Yongwei and Mager, Sela and Lester, Henry A. (1997) H⁺ Permeation and pH Regulation at a Mammalian Serotonin Transporter. Journal of Neuroscience, 17 (7). pp. 2257-2266. ISSN 0270-6474. PMCID PMC6573487. https://resolver.caltech.edu/CaltechAUTHORS:20191030-144551486

Bradley, Jonathan and Zhang, Yinong and Bakin, Robert et al. (1997) Functional Expression of the Heteromeric “Olfactory” Cyclic Nucleotide-Gated Channel in the Hippocampus: A Potential Effector of Synaptic Plasticity in Brain Neurons. Journal of Neuroscience, 17 (6). pp. 1993-2005. ISSN 0270-6474. PMCID PMC6793760. https://resolver.caltech.edu/CaltechAUTHORS:20160401-135631881

1996

Silverman, Scott K. and Kofuji, Paulo and Dougherty, Dennis A. et al. (1996) A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation. Proceedings of the National Academy of Sciences of the United States of America, 93 (26). pp. 15429-15434. ISSN 0027-8424. PMCID PMC26421. https://resolver.caltech.edu/CaltechAUTHORS:SILpnas96

Quick, Michael W. and Lester, Henry A. and Davidson, Norman et al. (1996) Desensitization of Inositol 1,4,5-Trisphosphate/Ca2+-induced Cl- Currents by Prolonged Activation of G Proteins in Xenopus Oocytes. Journal of Biological Chemistry, 271 (50). pp. 32021-32027. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:QUIjbc96

Kearney, Patrick C. and Zhang, Haiyun and Zhong, Wenge et al. (1996) Determinants of Nicotinic Receptor Gating in Natural and Unnatural Side Chain Structures at the M2 9′ Position. Neuron, 17 (6). pp. 1221-1229. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20200518-070216780

Silverman, Scott K. and Lester, Henry A. and Dougherty, Dennis A. (1996) Subunit Stoichiometry of a Heteromultimeric G protein-coupled Inward-rectifier K^+ Channel. Journal of Biological Chemistry, 271 (48). pp. 30524-30528. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:20120207-144820693

Kearney, Patrick C. and Nowak, Mark W. and Zhong, Wenge et al. (1996) Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists. Molecular Pharmacology, 50 (5). pp. 1401-1412. ISSN 0026-895X. https://resolver.caltech.edu/CaltechAUTHORS:20200626-123657699

Saks, Margaret E. and Sampson, Jeffrey R. and Nowak, Mark W. et al. (1996) An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression. Journal of Biological Chemistry, 271 (38). pp. 23169-23175. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:SAKjbc96

Mager, Sela and Kleinberger-Doron, Nurit and Keshet, Gilmor I. et al. (1996) Ion Binding and Permeation at the GABA Transporter GAT1. Journal of Neuroscience, 16 (17). pp. 5405-5414. ISSN 0270-6474. PMCID PMC6578888. https://resolver.caltech.edu/CaltechAUTHORS:20191030-155045434

Schreibmayer, Wolfgang and Dessauer, Carmen W. and Voroblov, Dmitry et al. (1996) Inhibition of an inwardly rectifying K^+ channel by G-protein ɑ-subunits. Nature, 380 (6575). pp. 624-627. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150610-111824247

Figl, Antonio and Labarca, Cesar and Davidson, Norman et al. (1996) Voltage-Jump Relaxation Kinetics for Wild-type and Chimeric β Subunits of Neuronal Nicotinic Receptors. Journal of General Physiology, 107 (3). pp. 369-379. ISSN 0022-1295. PMCID PMC2216994. https://resolver.caltech.edu/CaltechAUTHORS:20120208-075012754

Su, Alyce and Mager, Sela and Mayo, Stephen L. et al. (1996) A multi-substrate single-file model for ion-coupled transporters. Biophysical Journal, 70 (2). pp. 762-777. ISSN 0006-3495. PMCID PMC1224976. https://resolver.caltech.edu/CaltechAUTHORS:20110620-160434844

1995

Labarca, Cesar and Nowak, Mark W. and Zhang, Halyun et al. (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature, 376 (6540). pp. 514-516. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150610-113831280

Dascal, Nathan and Doupnik, Craig A. and Ivanina, Tatiana et al. (1995) Inhibition of function in Xenopus oocytes of the inwardly rectifying G-protein-activated atrial K channel (GIRK1) by overexpression of a membrane-attached form of the C-terminal tail. Proceedings of the National Academy of Sciences of the United States of America, 92 (15). pp. 6758-6762. ISSN 0027-8424. PMCID PMC41408. https://resolver.caltech.edu/CaltechAUTHORS:DASpnas95

Kofuji, Paulo and Davidson, Norman and Lester, Henry A. (1995) Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by Gβγ subunits and function as heteromultimers. Proceedings of the National Academy of Sciences of the United States of America, 92 (14). pp. 6542-6546. ISSN 0027-8424. PMCID PMC41554. https://resolver.caltech.edu/CaltechAUTHORS:KOFpnas95

Doupnik, Craig A. and Lim, Nancy F. and Kofuji, Paulo et al. (1995) Intrinsic Gating Properties of a Cloned G Protein-activated Inward Rectifier K^+ Channel. Journal of General Physiology, 106 (1). pp. 1-23. ISSN 0022-1295. PMCID PMC2229253. https://resolver.caltech.edu/CaltechAUTHORS:20120216-103326772

Cohen, B. N. and Figl, A. and Quick, M. W. et al. (1995) Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors. Journal of General Physiology, 105 (6). pp. 745-764. ISSN 0022-1295. PMCID PMC2216958. https://resolver.caltech.edu/CaltechAUTHORS:COHjgp95

Nowak, Mark W. and Kearney, Patrick C. and Sampson, Jeffrey R. et al. (1995) Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells. Science, 268 (5209). pp. 439-442. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150120-140412390

Lim, Nancy Fidler and Dascal, Nathan and Labarca, Cesar et al. (1995) A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes. Journal of General Physiology, 105 (3). pp. 421-439. ISSN 0022-1295. PMCID PMC2216943. https://resolver.caltech.edu/CaltechAUTHORS:LIMjgp95

1994

Quick, Michael W. and Simon, Melvin I. and Davidson, Norman et al. (1994) Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes. Journal of Biological Chemistry, 269 (48). pp. 30164-30172. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:QUIjbc94

Bradley, Jonathan and Li, Jun and Davidson, Norman et al. (1994) Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proceedings of the National Academy of Sciences of the United States of America, 91 (19). pp. 8890-8894. ISSN 0027-8424. PMCID PMC44712. https://resolver.caltech.edu/CaltechAUTHORS:BRApnas94

Karschin, Christine and Schreibmayer, Wolfgang and Dascal, Nathan et al. (1994) Distribution and localization of a G protein-coupled inwardly rectifying K^+ channel in the rat. FEBS Letters, 348 (2). pp. 139-144. ISSN 0014-5793. https://resolver.caltech.edu/CaltechAUTHORS:20170408-205029469

Corey, Janis L. and Davidson, Norman and Lester, Henry A. et al. (1994) Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter. Journal of Biological Chemistry, 269 (20). pp. 14759-14767. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:CORjbc94

Lester, Henry A. and Mager, Sela and Quick, Michael W. et al. (1994) Permeation Properties of Neurotransmitter Transporters. Annual Review of Pharmacology and Toxicology, 34 . pp. 219-249. ISSN 0362-1642. https://resolver.caltech.edu/CaltechAUTHORS:20120222-112704352

Corey, Janis L. and Quick, Michael W. and Davidson, Norman et al. (1994) A cocaine-sensitive Drosophila serotonin transporter: Cloning, expression, and electrophysiological characterization. Proceedings of the National Academy of Sciences of the United States of America, 91 (3). pp. 1188-1192. ISSN 0027-8424. PMCID PMC521479. https://resolver.caltech.edu/CaltechAUTHORS:20141210-095231086

1993

Dascal, Nathan and Schreibmayer, Wolfgang and Lim, Nancy F. et al. (1993) Atrial G protein-activated K+ channel: expression cloning and molecular properties. Proceedings of the National Academy of Sciences of the United States of America, 90 (21). pp. 10235-10239. ISSN 0027-8424. PMCID PMC47749. https://resolver.caltech.edu/CaltechAUTHORS:DASpnas93b

Slepak, Vladlen Z. and Quick, Michael W. and Aragay, Anna M. et al. (1993) Random Mutagenesis of G protein ɑ Subunit G_oɑ. Mutations altering nucleotide binding. Journal of Biological Chemistry, 268 (29). pp. 21889-21894. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:20120307-154341054

Lester, Henry A. and Dascal, Nathan (1993) The response to vagusstoff. Nature, 364 (6440). pp. 758-759. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150609-125940793

Dascal, Nathan and Lim, Nancy F. and Schreibmayer, Wolfgang et al. (1993) Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America, 90 (14). pp. 6596-6600. ISSN 0027-8424. PMCID PMC46979. https://resolver.caltech.edu/CaltechAUTHORS:DASpnas93

McCarthy, N. A. and McDonough, S. and Cohen, B. N. et al. (1993) Voltage-dependent Block of the Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channel by Two Closely Related Arylaminobenzoates. Journal of General Physiology, 102 (1). pp. 1-23. ISSN 0022-1295. PMCID PMC2229162. https://resolver.caltech.edu/CaltechAUTHORS:20120309-113518954

Uezono, Y. and Bradley, J. and Min, C. et al. (1993) Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors & Channels, 1 (3). pp. 233-241. ISSN 1060-6823. https://resolver.caltech.edu/CaltechAUTHORS:20151217-104726852

1992

Cohen, Bruce N. and Labarca, Cesar and Davidson, Norman et al. (1992) Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations. Journal of General Physiology, 100 (3). pp. 373-400. ISSN 0022-1295. PMCID PMC2229089. https://resolver.caltech.edu/CaltechAUTHORS:COHjgp92a

Guastella, John and Brecha, Nicholas and Weigmann, Christine et al. (1992) Cloning, expression, and localization of a rat brain high-affinity glycine transporter. Proceedings of the National Academy of Sciences of the United States of America, 89 (15). pp. 7189-7193. ISSN 0027-8424. PMCID PMC49671. https://resolver.caltech.edu/CaltechAUTHORS:GUApnas92

Lester, Henry A. (1992) The Permeation Pathway of Neurotransmitter-Gated Ion Channels. Annual Review of Biophysics and Biomolecular Structure, 21 . pp. 267-292. ISSN 1056-8700. https://resolver.caltech.edu/CaltechAUTHORS:20120329-091749403

Cohen, Bruce N. and Labarca, Cesar and Czyzyk, Linda et al. (1992) Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region. Journal of General Physiology, 99 (4). pp. 545-572. ISSN 0022-1295. PMCID PMC2219204. https://resolver.caltech.edu/CaltechAUTHORS:COHjgp92b

Yang, Xian-cheng and Labarca, Cesar and Nargeot, Joel et al. (1992) Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel α-subunit expressed in mammalian cells. Journal of Neuroscience, 12 (1). pp. 268-277. ISSN 0270-6474. PMCID PMC6575683. https://resolver.caltech.edu/CaltechAUTHORS:20191101-161058438

1991

Lester, Henry A. (1991) Strategies for studying permeation at voltage-gated ion channels. Annual Review of Physiology, 53 . pp. 477-496. ISSN 0066-4278. https://resolver.caltech.edu/CaltechAUTHORS:LESarp91

Walter, A. E. and Hoger, J. H. and Labarca, C. et al. (1991) Low Molecular Weight mRNA Encodes a Protein That Controls Serotonin 5-HT_(1c) and Acetylcholine M_1 Receptor Sensitivity in Xenopus Oocytes. Journal of General Physiology, 98 (2). pp. 399-417. ISSN 0022-1295. PMCID PMC2229050. https://resolver.caltech.edu/CaltechAUTHORS:20120420-071637268

Karschin, Andreas and Ho, Begonia Y. and Labarca, Cesar et al. (1991) Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart. Proceedings of the National Academy of Sciences of the United States of America, 88 (13). pp. 5694-5698. ISSN 0027-8424. PMCID PMC51944. https://resolver.caltech.edu/CaltechAUTHORS:KARpnas91

1990

Ahmed, C. M. lqbal and Auld, Vanessa J. and Lester, Henry A. et al. (1990) Both sodium channel II and IIA alpha subunits are expressed in rat brain. Nucleic Acids Research, 18 (19). p. 5907. ISSN 0305-1048. PMCID PMC332354. https://resolver.caltech.edu/CaltechAUTHORS:AHMnar90

Krafte, Douglas S. and Goldin, Alan L. and Auld, Vanessa J. et al. (1990) Inactivation of cloned Na channels expressed in Xenopus oocytes. Journal of General Physiology, 96 (4). pp. 689-706. ISSN 0022-1295. PMCID PMC2229013. https://resolver.caltech.edu/CaltechAUTHORS:KRAjgp90

Guastella, John and Nelson, Nathan and Nelson, Hannah et al. (1990) Cloning and expression of a rat brain GABA transporter. Science, 249 (4974). pp. 1303-1306. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141222-150126708

Snutch, Terry P. and Leonard, John P. and Gilbert, Mary M. et al. (1990) Rat brain expresses a heterogeneous family of calcium channels. Proceedings of the National Academy of Sciences of the United States of America, 87 (9). pp. 3391-3395. ISSN 0027-8424. PMCID PMC53906. https://resolver.caltech.edu/CaltechAUTHORS:SNUpnas90

Auld, V. J. and Goldin, A. L. and Krafte, D. S. et al. (1990) A Neutral Amino Acid Change in Segment IIS4 Dramatically Alters the Gating Properties of the Voltage-Dependent Sodium Channel. Proceedings of the National Academy of Sciences of the United States of America, 87 (1). pp. 323-327. ISSN 0027-8424. PMCID PMC53255. https://resolver.caltech.edu/CaltechAUTHORS:AULpnas90

Charnet, Pierre and Labarca, Cesar and Leonard, Reid J. et al. (1990) An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor. Neuron, 4 (1). pp. 87-95. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20170408-161145019

1989

Yu, Lei and Blumer, Kendall J. and Davidson, Norman et al. (1989) Functional expression of the yeast alpha-factor receptor in Xenopus oocytes. Journal of Biological Chemistry, 264 (35). pp. 20847-20850. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:YULjbc89

Leonard, R. J. and Karschin, A. and Jayashree-Aiyar, S. et al. (1989) Expression of Drosophila Shaker potassium channels in mammalian cells infected with recombinant vaccinia virus. Proceedings of the National Academy of Sciences of the United States of America, 86 (19). pp. 7629-7633. ISSN 0027-8424. PMCID PMC298120. https://resolver.caltech.edu/CaltechAUTHORS:LEOpnas89

1988

Leonard, Reid J. and Labarca, Cesar G. and Charnet, Pierre et al. (1988) Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science, 242 (4885). pp. 1578-1581. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150128-145454703

Lester, Henry A. (1988) Heterologous Expression of Excitability Proteins: Route to More Specific Drugs? Science, 241 (4869). pp. 1057-1063. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141222-150346710

Iverson, L. E. and Tanouye, M. A. and Lester, H. A. et al. (1988) A-Type Potassium Channels Expressed from Shaker Locus cDNA. Proceedings of the National Academy of Sciences of the United States of America, 85 (15). pp. 5723-5727. ISSN 0027-8424. PMCID PMC281833. https://resolver.caltech.edu/CaltechAUTHORS:IVEpnas88b

Krafte, Douglas S. and Snutch, Terry P. and Leonard, John P. et al. (1988) Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes. Journal of Neuroscience, 8 (8). pp. 2859-2868. ISSN 0270-6474. PMCID PMC6569391. https://resolver.caltech.edu/CaltechAUTHORS:20191104-094627196

1987

Yoshii, Kiyonori and Yu, Lei and Mayne, Katharine Mixter et al. (1987) Equilibrium Properties of Mouse-Torpedo Acetylcholine Receptor Hybrids Expressed in Xenopus Oocytes. Journal of General Physiology, 90 (4). pp. 553-573. ISSN 0022-1295. PMCID PMC2228871. https://resolver.caltech.edu/CaltechAUTHORS:20120622-143923786

Lübbert, Hermann and Hoffman, Beth J. and Snutch, Terry P. et al. (1987) cDNA Cloning of a Serotonin 5-HT1C Receptor by Electrophysiological Assays of mRNA-Injected Xenopus Oocytes. Proceedings of the National Academy of Sciences of the United States of America, 84 (12). pp. 4332-4336. ISSN 0027-8424. PMCID PMC305079. https://resolver.caltech.edu/CaltechAUTHORS:LUBpnas87

Gurney, Alison M. and Tsien, Roger Y. and Lester, Henry A. (1987) Activation of a Potassium Current by Rapid Photochemically Generated Step Increases of Intracellular Calcium in Rat Sympathetic Neurons. Proceedings of the National Academy of Sciences of the United States of America, 84 (10). pp. 3496-3500. ISSN 0027-8424. PMCID PMC304898. https://resolver.caltech.edu/CaltechAUTHORS:GURpnas87

1986

Goldin, Alan L. and Snutch, Terry P. and Lübbert, Hermann et al. (1986) Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America, 83 (19). pp. 7503-7507. ISSN 0027-8424. PMCID PMC386747. https://resolver.caltech.edu/CaltechAUTHORS:GOLpnas86

1985

Dascal, Nathan and Lotan, Ilana and Gillo, Boaz et al. (1985) Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America, 82 (17). pp. 6001-6005. ISSN 0027-8424. PMCID PMC390682. https://resolver.caltech.edu/CaltechAUTHORS:DASpnas85

Gurney, Alison M. and Nerbonne, Jeanne M. and Lester, Henry A. (1985) Photoinduced Removal of Nifedipine Reveals Mechanisms of Calcium Antagonist Action on Single Heart Cells. Journal of General Physiology, 86 (3). pp. 353-379. ISSN 0022-1295. PMCID PMC2228798. https://resolver.caltech.edu/CaltechAUTHORS:20120629-070830645

Krouse, Mauri E. and Lester, Henry A. and Wassermann, Norbert H. et al. (1985) Rates and Equilibria for a Photoisomerizable Antagonist at the Acetylcholine Receptor of Electrophorus Electroplaques. Journal of General Physiology, 86 (2). pp. 235-256. ISSN 0022-1295. PMCID PMC2228782. https://resolver.caltech.edu/CaltechAUTHORS:20120628-075949869

White, Michael M. and Mayne, Katharine Mixter and Lester, Henry A. et al. (1985) Mouse-Torpedo Hybrid Acetylcholine Receptors: Functional Homology Does not Equal Sequence Homology. Proceedings of the National Academy of Sciences of the United States of America, 82 (14). pp. 4852-4856. ISSN 0027-8424. PMCID PMC391003. https://resolver.caltech.edu/CaltechAUTHORS:WHIpnas85

1983

Nargeot, Joel and Nerbonne, Jeanne M. and Engels, Joachim et al. (1983) Time Course of the Increase in the Myocardial Slow Inward Current after a Photochemically Generated Concentration Jump of Intracellular cAMP. Proceedings of the National Academy of Sciences of the United States of America, 80 (8). pp. 2395-2399. ISSN 0027-8424. PMCID PMC393827. https://resolver.caltech.edu/CaltechAUTHORS:NARpnas83

1982

Sheridan, Robert E. and Lester, Henry A. (1982) Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel. Journal of General Physiology, 80 (4). pp. 499-515. ISSN 0022-1295. PMCID PMC2228709. https://resolver.caltech.edu/CaltechAUTHORS:20120717-113744311

Lester, Henry A. and Nerbonne, Jeanne M. (1982) Physiological and Pharmacological Manipulations with Light Flashes. Annual Review of Biophysics and Bioengineering, 11 . pp. 151-175. ISSN 0084-6589. https://resolver.caltech.edu/CaltechAUTHORS:20120717-132820326

Nargeot, Joel and Lester, Henry A. and Birdsall, Nigel J. M. et al. (1982) A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart. Journal of General Physiology, 79 (4). pp. 657-678. ISSN 0022-1295. PMCID PMC2215484. https://resolver.caltech.edu/CaltechAUTHORS:NARjgp82

Lester, Henry A. and Steer, Michael L. and Levitzki, Alexander (1982) Prostaglandin-Stimulated GTP Hydrolysis Associated with Activation of Adenylate Cyclase in Human Platelet Membranes. Proceedings of the National Academy of Sciences of the United States of America, 79 (3). pp. 719-723. ISSN 0027-8424. PMCID PMC345823. https://resolver.caltech.edu/CaltechAUTHORS:LESpnas82

1980

Lester, Henry A. and Krouse, Mauri E. and Nass, Menasche M. et al. (1980) A covalently bound photoisomerizable agonist. Comparison with reversibly bound agonists at electrophorus electroplaques. Journal of General Physiology, 75 (2). pp. 207-232. ISSN 0022-1295. PMCID PMC2215740. https://resolver.caltech.edu/CaltechAUTHORS:LESjgp80

1978

Lester, Henry A. (1978) Analysis of sodium and potassium redistribution during sustained permeability increases at the innervated face of Electrophorus electroplaques. Journal of General Physiology, 72 (6). pp. 857-862. ISSN 0022-1295. PMCID PMC2228490. https://resolver.caltech.edu/CaltechAUTHORS:LESjgp78

1977

Sheridan, Robert E. and Lester, Henry A. (1977) Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations. Journal of General Physiology, 70 (2). pp. 187-219. ISSN 0022-1295. PMCID PMC2228462. https://resolver.caltech.edu/CaltechAUTHORS:20120119-120416762

1975

Sheridan, Robert E. and Lester, Henry A. (1975) Relaxation measurements on the acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America, 72 (9). pp. 3496-3500. ISSN 0027-8424. PMCID PMC433021. https://resolver.caltech.edu/CaltechAUTHORS:SHEpnas75

Lester, Henry A. and Changeux, Jean-Pierre and Sheridan, Robert E. (1975) Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques. Journal of General Physiology, 65 (6). pp. 797-816. ISSN 0022-1295. PMCID PMC2214893. https://resolver.caltech.edu/CaltechAUTHORS:LESjgp75

This list was generated on Fri Aug 7 03:09:13 2020 PDT.