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Number of items: 97.

2019

Melnykov, Artem and Chen, Shun-Jia and Varshavsky, Alexander (2019) Gid10 as an alternative N-recognin of the Pro/N-degron pathway. Proceedings of the National Academy of Sciences of the United States of America, 116 (32). pp. 15914-15923. ISSN 0027-8424. https://resolver.caltech.edu/CaltechAUTHORS:20190725-112336927

Varshavsky, Alexander (2019) On the cause of sleep: Protein fragments, the concept of sentinels, and links to epilepsy. Proceedings of the National Academy of Sciences of the United States of America, 116 (22). pp. 10773-10782. ISSN 0027-8424. PMCID PMC6561186. https://resolver.caltech.edu/CaltechAUTHORS:20190513-150129586

Varshavsky, Alexander (2019) N-degron and C-degron pathways of protein degradation. Proceedings of the National Academy of Sciences of the United States of America, 116 (2). pp. 358-366. ISSN 0027-8424. https://resolver.caltech.edu/CaltechAUTHORS:20190108-090142944

2018

Kim, Jeong-Mok and Seok, Ok-Hee and Ju, Shinyeong et al. (2018) Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway. Science, 362 (6418). Art. No. eaat0174. ISSN 0036-8075. PMCID PMC6551516. https://resolver.caltech.edu/CaltechAUTHORS:20181108-125308990

Dougan, David A. and Varshavsky, Alexander (2018) Understanding the Pro/N-end rule pathway. Nature Chemical Biology, 14 (5). pp. 415-416. ISSN 1552-4450. https://resolver.caltech.edu/CaltechAUTHORS:20180416-140609766

2017

Oh, Jang-Hyun and Chen, Shun-Jia and Varshavsky, Alexander (2017) A reference-based protein degradation assay without global translation inhibitors. Journal of Biological Chemistry, 292 (52). pp. 21457-21465. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:20171113-111614515

Varshavsky, Alexander (2017) The Ubiquitin System, Autophagy, and Regulated Protein Degradation. Annual Review of Biochemistry, 86 . pp. 123-128. ISSN 0066-4154. https://resolver.caltech.edu/CaltechAUTHORS:20170628-083941867

Oh, Jang-Hyun and Hyun, Ju-Yeon and Varshavsky, Alexander (2017) Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway. Proceedings of the National Academy of Sciences of the United States of America, 114 (22). E4370-E4379. ISSN 0027-8424. https://resolver.caltech.edu/CaltechAUTHORS:20170518-073119611

Chen, Shun-Jia and Wu, Xia and Wadas, Brandon et al. (2017) An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes. Science, 355 (6323). Art. No. eaal3655. ISSN 0036-8075. PMCID PMC5457285. https://resolver.caltech.edu/CaltechAUTHORS:20170130-100756755

2016

Wadas, Brandon and Piatkov, Konstantin and Brower, Christopher et al. (2016) Analyzing N-terminal Arginylation Through the Use of Peptide Arrays and Degradation Assays. Journal of Biological Chemistry, 291 (40). Art. No. 20976. ISSN 0021-9258. PMCID PMC5076509. https://resolver.caltech.edu/CaltechAUTHORS:20160815-140416336

Wadas, Brandon and Borjigin, Jimo and Huang, Zheping et al. (2016) Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway. Journal of Biological Chemistry, 291 (33). pp. 17178-17196. ISSN 0021-9258. PMCID PMC5016120. https://resolver.caltech.edu/CaltechAUTHORS:20160706-082440341

Liu, Yu-Jiao and Liu, Chao and Chang, ZeNan et al. (2016) Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway. Journal of Biological Chemistry, 291 (14). pp. 7426-7438. ISSN 0021-9258. PMCID PMC4817174. https://resolver.caltech.edu/CaltechAUTHORS:20160218-082640962

2015

Piatkov, Konstantin and Vu, Tri and Hwang, Cheol-Sang et al. (2015) Formyl-methionine as a degradation signal at the N-termini of bacterial proteins. Microbial Cell, 2 (10). pp. 376-393. ISSN 2311-2638. PMCID PMC4745127. https://resolver.caltech.edu/CaltechAUTHORS:20160509-130856265

Park, Sang-Eun and Kim, Jeong-Mok and Seok, Ok-Hee et al. (2015) Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway. Science, 347 (6227). pp. 1249-1252. ISSN 0036-8075. PMCID PMC4748709. https://resolver.caltech.edu/CaltechAUTHORS:20150316-112138335

2014

Brower, Christopher S. and Rosen, Connor E. and Jones, Richard H. et al. (2014) Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats. Proceedings of the National Academy of Sciences of the United States of America, 111 (46). E4936-E4945. ISSN 0027-8424. PMCID PMC4246273. https://resolver.caltech.edu/CaltechAUTHORS:20141105-093127516

Varshavsky, Alexander (2014) Discovery of the Biology of the Ubiquitin System. JAMA : the journal of the American Medical Association, 311 (19). pp. 1969-1970. ISSN 0098-7484. https://resolver.caltech.edu/CaltechAUTHORS:20140613-125640695

Piatkov, Konstantin I. and Oh, Jang-Hyun and Liu, Yuan et al. (2014) Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway. Proceedings of the National Academy of Sciences of the United States of America, 111 (9). E817-E826. ISSN 0027-8424. PMCID PMC3948289. https://resolver.caltech.edu/CaltechAUTHORS:20140225-100028331

Kim, Heon-Ki and Kim, Ryu-Ryun and Oh, Jang Hyun et al. (2014) The N-Terminal Methionine of Cellular Proteins as a Degradation Signal. Cell, 156 (1). pp. 158-169. ISSN 0092-8674. PMCID PMC3988316. https://resolver.caltech.edu/CaltechAUTHORS:20140102-103647381

2013

Piatkov, Konstantin and Graciet, Emmanuelle and Varshavsky, Alexander (2013) Ubiquitin Reference Technique and Its Use in Ubiquitin-Lacking Prokaryotes. PLoS ONE, 8 (6). Art. No. e67952. ISSN 1932-6203. PMCID PMC3692480. https://resolver.caltech.edu/CaltechAUTHORS:20130813-094316614

Shemorry, Anna and Hwang, Cheol-Sang and Varshavsky, Alexander (2013) Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway. Molecular Cell, 50 (4). pp. 540-551. ISSN 1097-2765. PMCID PMC3665649. https://resolver.caltech.edu/CaltechAUTHORS:20130716-134300224

Brower, Christopher S. and Piatkov, Konstantin I. and Varshavsky, Alexander (2013) Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway. Molecular Cell, 50 (2). pp. 161-171. ISSN 1097-2765. PMCID PMC3640747. https://resolver.caltech.edu/CaltechAUTHORS:20130530-133709518

2012

Piatkov, Konstantin I. and Colnaghi, Luca and Békés, Miklos et al. (2012) The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway. Molecular Cell, 48 (6). pp. 926-933. ISSN 1097-2765. PMCID PMC3889152. https://resolver.caltech.edu/CaltechAUTHORS:20130211-154805502

Varshavsky, Alexander (2012) Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: A hypothesis. Protein Science, 21 (11). ISSN 0961-8368. PMCID PMC3527701. https://resolver.caltech.edu/CaltechAUTHORS:20120831-090649691

Piatkov, Konstantin I. and Brower, Christopher S. and Varshavsky, Alexander (2012) The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments. Proceedings of the National Academy of Sciences of the United States of America, 109 (27). E1839-E1847. ISSN 0027-8424. PMCID PMC3390858. https://resolver.caltech.edu/CaltechAUTHORS:20120817-134304319

Varshavsky, Alexander (2012) The Ubiquitin System, an Immense Realm. Annual Review of Biochemistry, 81 . pp. 167-176. ISSN 0066-4154. https://resolver.caltech.edu/CaltechAUTHORS:20120614-103921398

Varshavsky, Alexander (2012) Three decades of studies to understand the functions of the ubiquitin family. In: Ubiquitin family modifiers and the proteasome: reviews and protocols. Methods in molecular biology. No.832. Humana Press , New York, pp. 1-11. ISBN 9781617794742 . https://resolver.caltech.edu/CaltechAUTHORS:20120227-084239400

2011

Hwang, Cheol-Sang and Sukalo, Maja and Batygin, Olga et al. (2011) Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome. PLoS ONE, 6 (9). Art.No. e24925. ISSN 1932-6203. https://resolver.caltech.edu/CaltechAUTHORS:20111025-084945445

Varshavsky, Alexander (2011) The N-end rule pathway and regulation by proteolysis. Protein Science, 20 (8). pp. 1298-1345. ISSN 0961-8368. PMCID PMC3189519. https://resolver.caltech.edu/CaltechAUTHORS:20110819-091924451

2010

Hwang, Cheol-Sang and Shemorry, Anna and Auerbach, Daniel et al. (2010) The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases. Nature Cell Biology, 12 (12). pp. 1177-1185. ISSN 1465-7392. PMCID PMC3003441. https://resolver.caltech.edu/CaltechAUTHORS:20101220-134450477

Brower, Christopher S. and Veiga, Lucia and Jones, Richard H. et al. (2010) Mouse Dfa Is a Repressor of TATA-box Promoters and Interacts with the Abt1 Activator of Basal Transcription. Journal of Biological Chemistry, 285 (22). pp. 17218-17234. ISSN 0021-9258. PMCID PMC2878062. https://resolver.caltech.edu/CaltechAUTHORS:20100615-141115251

Hwang, Cheol-Sang and Shemorry, Anna and Varshavsky, Alexander (2010) N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals. Science, 327 (5968). pp. 973-977. ISSN 0036-8075. PMCID PMC4259118. https://resolver.caltech.edu/CaltechAUTHORS:20100301-145500742

2009

Brower, Christopher S. and Varshavsky, Alexander (2009) Ablation of Arginylation in the Mouse N-End Rule Pathway: Loss of Fat, Higher Metabolic Rate, Damaged Spermatogenesis, and Neurological Perturbations. PLoS ONE, 4 (11). Art. No. e7757 . ISSN 1932-6203. https://resolver.caltech.edu/CaltechAUTHORS:20100127-092828613

Graciet, Emmanuelle and Walter, Franziska and Ó Maoiléidigh, Diarmuid et al. (2009) The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development. Proceedings of the National Academy of Sciences of the United States of America, 106 (32). pp. 13618-13623. ISSN 0027-8424. PMCID PMC2726413. https://resolver.caltech.edu/CaltechAUTHORS:20090828-231031940

Wang, Haiqing and Piatkov, Konstantin I. and Brower, Christopher S. et al. (2009) Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway. Molecular Cell, 34 (6). pp. 686-695. ISSN 1097-2765. PMCID PMC2749074. https://resolver.caltech.edu/CaltechAUTHORS:20090828-112810807

Hwang, Cheol-Sang and Shemorry, Anna and Varshavsky, Alexander (2009) Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase. Proceedings of the National Academy of Sciences of the United States of America, 106 (7). pp. 2142-2147. ISSN 0027-8424. PMCID PMC2650122. https://resolver.caltech.edu/CaltechAUTHORS:20090827-155821961

2008

Varshavsky, Alexander (2008) Discovery of cellular regulation by protein degradation. Journal of Biological Chemistry, 283 (50). pp. 34469-34489. ISSN 0021-9258. PMCID PMC3259866. https://resolver.caltech.edu/CaltechAUTHORS:VARjbc08

Hwang, Cheol-Sang and Varshavsky, Alexander (2008) Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway. Proceedings of the National Academy of Sciences of the United States of America, 105 (49). pp. 19188-19193. ISSN 0027-8424. PMCID PMC2614737. https://resolver.caltech.edu/CaltechAUTHORS:HWApnas08

Varshavsky, Alexander (2008) The N-end rule at atomic resolution. Nature Structural & Molecular Biology, 15 (12). pp. 1238-1240. ISSN 1545-9985. https://resolver.caltech.edu/CaltechAUTHORS:VARnsmb08

Xia, Zanxian and Turner, Glenn C. and Hwang, Cheol-Sang et al. (2008) Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter. Journal of Biological Chemistry, 283 (43). pp. 28958-28968. ISSN 0021-9258. PMCID PMC2570885. https://resolver.caltech.edu/CaltechAUTHORS:XIAjbc08b

Xia, Zanxian and Webster, Ailsa and Du, Fangyong et al. (2008) Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway. Journal of Biological Chemistry, 283 (35). pp. 24011-24028. ISSN 0021-9258. PMCID PMC2527112. https://resolver.caltech.edu/CaltechAUTHORS:XIAjbc08

Connor, Rebecca E. and Piatkov, Konstantin and Varshavsky, Alexander et al. (2008) Enzymatic N-terminal Addition of Noncanonical Amino Acids to Peptides and Proteins. ChemBioChem, 9 (3). pp. 366-369. ISSN 1439-4227. https://resolver.caltech.edu/CaltechAUTHORS:20150112-114337627

Hu, Rong-Gui and Wang, Haiqing and Xia, Zanxian et al. (2008) The N-end rule pathway is a sensor of heme. Proceedings of the National Academy of Sciences of the United States of America, 105 (1). pp. 76-81. ISSN 0027-8424. PMCID PMC2224235. https://resolver.caltech.edu/CaltechAUTHORS:HURpnas08

2007

Schnupf, Pamela and Zhou, Jianmin and Varshavsky, Alexander et al. (2007) Listeriolysin O Secreted by Listeria monocytogenes into the Host Cell Cytosol Is Degraded by the N-End Rule Pathway. Infection and Immunity, 75 (11). pp. 5135-5147. ISSN 0019-9567. PMCID PMC2168281. https://resolver.caltech.edu/CaltechAUTHORS:SCHNUiai07

Varshavsky, Alexander (2007) Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy. Proceedings of the National Academy of Sciences of the United States of America, 104 (38). pp. 14935-14940. ISSN 0027-8424. PMCID PMC1986591. https://resolver.caltech.edu/CaltechAUTHORS:VARpnas07

Tasaki, Takafumi and Sohr, Reinhard and Xia, Zanxian et al. (2007) Biochemical and Genetic Studies of UBR3, a Ubiquitin Ligase with a Function in Olfactory and Other Sensory Systems. Journal of Biological Chemistry, 282 (25). pp. 18510-18520. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:TASjbc07

2006

Hu, Rong-Gui and Brower, Christopher S. and Wang, Haiqing et al. (2006) Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms. Journal of Biological Chemistry, 281 (43). pp. 32559-32573. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:HURjbc06

An, Jee Young and Seo, Jai Wha and Tasaki, Takafumi et al. (2006) Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Proceedings of the National Academy of Sciences of the United States of America, 103 (16). pp. 6212-6217. ISSN 0027-8424. PMCID PMC1458857. https://resolver.caltech.edu/CaltechAUTHORS:ANJpnas06

Graciet, Emmanuelle and Hu, Rong-Gui and Piatkov, Konstantin et al. (2006) Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen. Proceedings of the National Academy of Sciences of the United States of America, 103 (9). pp. 3078-3083. ISSN 0027-8424. PMCID PMC1413915. https://resolver.caltech.edu/CaltechAUTHORS:GRApnas06a

2005

Zenker, Martin and Varshavsky, Alexander (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nature Genetics, 37 (12). pp. 1345-1350. ISSN 1061-4036. https://resolver.caltech.edu/CaltechAUTHORS:20150319-070411230

Hu, Rong-Gui and Sheng, Jun and Xu, Zhenming et al. (2005) The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. Nature, 437 (7061). pp. 981-989. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150325-092008023

Tasaki, Takafumi and Mulder, Lubbertus C. F. and Iwamatsu, Akihiro et al. (2005) A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons. Molecular and Cellular Biology, 25 (16). pp. 7120-7136. ISSN 0270-7306. PMCID PMC1190250. https://resolver.caltech.edu/CaltechAUTHORS:TASmcb05

2004

Yin, Jinhu and Kwon, Yong Tae and Varshavsky, Alexander et al. (2004) RECQL4, mutated in the Rothmund–Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Human Molecular Genetics, 13 (20). pp. 2421-2430. ISSN 0964-6906. https://resolver.caltech.edu/CaltechAUTHORS:20111004-142209812

2003

Kwon, Yong Tae and Xia, Zanxian and An, Jee Young et al. (2003) Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway. Molecular and Cellular Biology, 23 (22). pp. 8255-8271. ISSN 0270-7306. PMCID PMC262401. https://resolver.caltech.edu/CaltechAUTHORS:KWOmcb03

Varshavsky, Alexander (2003) The N-end rule and regulation of apoptosis. Nature Cell Biology, 5 (5). pp. 373-376. ISSN 1465-7392. https://resolver.caltech.edu/CaltechAUTHORS:20150325-153608289

2002

Xie, Youming and Varshavsky, Alexander (2002) UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis. Nature Cell Biology, 4 (12). pp. 1003-1007. ISSN 1465-7392. https://resolver.caltech.edu/CaltechAUTHORS:20150325-152811477

Du, Fangyong and Navarro-Garcia, Federico and Xia, Zanxian et al. (2002) Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain. Proceedings of the National Academy of Sciences of the United States of America, 99 (22). pp. 14110-14115. ISSN 0027-8424. PMCID PMC137845. https://resolver.caltech.edu/CaltechAUTHORS:DUFpnas02

Kwon, Yong Tae and Kashina, Anna S. and Davydov, Ilia V. et al. (2002) An Essential Role of N-Terminal Arginylation in Cardiovascular Development. Science, 297 (5578). pp. 96-99. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141114-160435229

2001

Kwon, Yong Tae and Xia, Zanxian and Davydov, Ilia V. et al. (2001) Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway. Molecular and Cellular Biology, 21 (23). pp. 8007-8021. ISSN 0270-7306. PMCID PMC99968. https://resolver.caltech.edu/CaltechAUTHORS:KWOmcb01

Rao, Hai and Uhlmann, Frank and Nasmyth, Kim et al. (2001) Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability. Nature, 410 (6831). p. 955. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150331-072449879

Xie, Youming and Varshavsky, Alexander (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit. Proceedings of the National Academy of Sciences of the United States of America, 98 (6). pp. 3056-3061. ISSN 0027-8424. PMCID PMC30606. https://resolver.caltech.edu/CaltechAUTHORS:XIEpnas01

2000

Hershko, Avram and Ciechanover, Aaron and Varshavsky, Alexander (2000) The ubiquitin system. Nature Medicine, 6 (10). pp. 1073-1081. ISSN 1078-8956 . https://resolver.caltech.edu/CaltechAUTHORS:20150513-100923361

Turner, Glenn C. and Varshavsky, Alexander (2000) Detecting and Measuring Cotranslational Protein Degradation in Vivo. Science, 289 (5487). pp. 2117-2120. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141112-112135305

Varshavsky, Alexander and Turner, Glenn and Du, Fangyong et al. (2000) The Ubiquitin System and the N-End Rule Pathway. Biological Chemistry, 381 (9-10). pp. 779-789. ISSN 1431-6730. https://resolver.caltech.edu/CaltechAUTHORS:20180803-074725065

Kwon, Yong Tae and Balogh, Seth A. and Davydov, Ilia V. et al. (2000) Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway. Molecular and Cellular Biology, 20 (11). pp. 4135-4148. ISSN 0270-7306. PMCID PMC85783. https://resolver.caltech.edu/CaltechAUTHORS:KWOmcb00

Turner, Glenn C. and Du, Fangyong and Varshavsky, Alexander (2000) Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway. Nature, 405 (6786). p. 579. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150330-105345474

Davydov, Ilia V. and Varshavsky, Alexander (2000) RGS4 is arginylated and degraded by the N-end rule pathway in vitro. Journal of Biological Chemistry, 275 (30). pp. 22931-22941. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:DAVjbc00

Xie, Youming and Varshavsky, Alexander (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proceedings of the National Academy of Sciences of the United States of America, 97 (6). pp. 2497-2502. ISSN 0027-8424. PMCID PMC15957. https://resolver.caltech.edu/CaltechAUTHORS:XIEpnas00

1999

Kwon, Yong Tae and Lévy, Frédéric and Varshavsky, Alexander (1999) Bivalent Inhibitor of the N-end Rule Pathway. Journal of Biological Chemistry, 274 (25). pp. 18135-18139. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:KWOjbc99

Dünnwald, Martin and Varshavsky, Alexander and Johnsson, Nils (1999) Detection of Transient In Vivo Interactions between Substrate and Transporter during Protein Translocation into the Endoplasmic Reticulum. Molecular Biology of the Cell, 10 (2). pp. 329-344. ISSN 1059-1524. PMCID PMC25172. https://resolver.caltech.edu/CaltechAUTHORS:DUNmbc99

Kwon, Yong Tae and Kashina, Anna S. and Varshavsky, Alexander (1999) Alternative Splicing Results in Differential Expression, Activity, and Localization of the Two Forms of Arginyl-tRNA-Protein Transferase, a Component of the N-End Rule Pathway. Molecular and Cellular Biology, 19 (1). pp. 182-193. ISSN 0270-7306. PMCID PMC83877. https://resolver.caltech.edu/CaltechAUTHORS:KWOmcb99

1998

Kwon, Yong Tae and Reiss, Yuval and Fried, Victor A. et al. (1998) The mouse and human genes encoding the recognition component of the N-end rule pathway. Proceedings of the National Academy of Sciences of the United States of America, 95 (14). pp. 7898-7903. ISSN 0027-8424. PMCID PMC20901. https://resolver.caltech.edu/CaltechAUTHORS:KWOpnas98

Varshavsky, Alexander (1998) Codominant interference, antieffectors, and multitarget drugs. Proceedings of the National Academy of Sciences of the United States of America, 95 (5). pp. 2094-2099. ISSN 0027-8424. PMCID PMC19261. https://resolver.caltech.edu/CaltechAUTHORS:VARpnas98

1996

Grigoryev, Sergei and Stewart, Albert E. and Kwon, Yong Tae et al. (1996) A Mouse Amidase Specific for N-terminal Asparagine: the gene, the enzyme, and their function in the N-end rule pathway. Journal of Biological Chemistry, 271 (45). pp. 28521-28532. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:GRIjbc96

Varshavsky, Alexander (1996) The N-end rule: Functions, mysteries, uses. Proceedings of the National Academy of Sciences of the United States of America, 93 (22). pp. 12142-12149. ISSN 0027-8424. PMCID PMC37957. https://resolver.caltech.edu/CaltechAUTHORS:VARpnas96

Lévy, Frédéric and Johnsson, Nils and Rümenapf, Tillmann et al. (1996) Using ubiquitin to follow the metabolic fate of a protein. Proceedings of the National Academy of Sciences of the United States of America, 93 (10). pp. 4907-4912. ISSN 0027-8424. PMCID PMC39378. https://resolver.caltech.edu/CaltechAUTHORS:LEVpnas96

1995

Varshavsky, Alexander (1995) Codominance and toxins: A path to drugs of nearly unlimited selectivity. Proceedings of the National Academy of Sciences of the United States of America, 92 (9). pp. 3663-3667. ISSN 0027-8424. PMCID PMC42021. https://resolver.caltech.edu/CaltechAUTHORS:VARpnas95

1994

Johnsson, Nils and Varshavsky, Alexander (1994) Split ubiquitin as a sensor of protein interactions in vivo. Proceedings of the National Academy of Sciences of the United States of America, 91 (22). pp. 10340-10344. ISSN 0027-8424. PMCID PMC45015. https://resolver.caltech.edu/CaltechAUTHORS:JOHpnas94

Madura, Kiran and Varshavsky, Alexander (1994) Degradation of Gα by the N-End Rule Pathway. Science, 265 (5177). pp. 1454-1458. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150121-092636074

Dohmen, R. Jürgen and Wu, Peipei and Varshavsky, Alexander (1994) Heat-Inducible Degron: A Method for Constructing Temperature-Sensitive Mutants. Science, 263 (5151). pp. 1273-1276. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150120-134752646

1993

Ota, Irene M. and Varshavsky, Alexander (1993) A yeast protein similar to bacterial two-component regulators. Science, 262 (5133). pp. 566-569. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150122-121838530

Shrader, Thomas E. and Tobias, John W. and Varshavsky, Alexander (1993) The N-End Rule in Escherichia coli: Cloning and Analysis of the Leucyl, Phenylalanyl-tRNA-Protein Transferase Gene aat. Journal of Bacteriology, 175 (14). pp. 4364-4374. ISSN 0021-9193. PMCID PMC204876. https://resolver.caltech.edu/CaltechAUTHORS:20120308-111115401

1992

Ota, Irene M. and Varshavsky, Alexander (1992) A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant. Proceedings of the National Academy of Sciences of the United States of America, 89 (6). pp. 2355-2359. ISSN 0027-8424. PMCID PMC48656. https://resolver.caltech.edu/CaltechAUTHORS:OTApnas92

1991

Dohmen, R. Jurgen and Madura, Kiran and Bartel, Bonnie et al. (1991) The N-End Rule is Mediated by the UBC2(RAD6) Ubiquitin-Conjugating Enzyme. Proceedings of the National Academy of Sciences of the United States of America, 88 (16). pp. 7351-7355. ISSN 0027-8424. PMCID PMC52293. https://resolver.caltech.edu/CaltechAUTHORS:DOHpnas91

Hochstrasser, Mark and Ellison, Michael J. and Chau, Vincent et al. (1991) The short-lived MATα2 transcriptional regulator is ubiquitinated in vivo. Proceedings of the National Academy of Sciences of the United States of America, 88 (11). pp. 4606-4610. ISSN 0027-8424. PMCID PMC51714. https://resolver.caltech.edu/CaltechAUTHORS:HOCpnas91

Baker, Rohan T. and Varshavsky, Alexander (1991) Inhibition of the N-end rule pathway in living cells. Proceedings of the National Academy of Sciences of the United States of America, 88 (4). pp. 1090-1094. ISSN 0027-8424. PMCID PMC50962. https://resolver.caltech.edu/CaltechAUTHORS:BAKpnas91

1987

Peck, Lawrence J. and Millstein, Larry and Eversole-Cire, Pamela et al. (1987) Transcriptionally inactive oocyte-type 5S RNA genes of Xenopus laevis are complexed with TFIIIA in vitro. Molecular and Cellular Biology, 7 (10). pp. 3503-3510. ISSN 0270-7306. PMCID PMC368002. https://resolver.caltech.edu/CaltechAUTHORS:PECmcb87

Solomon, Mark J. and Varshavsky, Alexander (1987) A nuclease-hypersensitive region forms de novo after chromosome replication. Molecular and Cellular Biology, 7 (10). pp. 3822-3825. ISSN 0270-7306. PMCID PMC368040. https://resolver.caltech.edu/CaltechAUTHORS:SOLmcb87

1986

Snapka, Robert M. and Kwok, Kwan and Bernard, John A. et al. (1986) Post-separation detection of nucleic acids and proteins by neutron activation. Proceedings of the National Academy of Sciences of the United States of America, 83 (23). pp. 8939-8942. ISSN 0027-8424. PMCID PMC387049. https://resolver.caltech.edu/CaltechAUTHORS:SNApnas86

Solomon, Mark J. and Strauss, Francois and Varshavsky, Alexander (1986) A mammalian high mobility group protein recognizes any stretch of six A·T base pairs in duplex DNA. Proceedings of the National Academy of Sciences of the United States of America, 83 (5). pp. 1276-1280. ISSN 0027-8424. PMCID PMC323058. https://resolver.caltech.edu/CaltechAUTHORS:SOLpnas86

Gros, Philippe and Croop, James and Roninson, Igor et al. (1986) Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proceedings of the National Academy of Sciences of the United States of America, 83 (2). pp. 337-341. ISSN 0027-8424. PMCID PMC322853. https://resolver.caltech.edu/CaltechAUTHORS:GROpnas86

1985

Solomon, Mark J. and Varshavsky, Alexander (1985) Formaldehyde-mediated DNA-protein crosslinking: A probe for in vivo chromatin structures. Proceedings of the National Academy of Sciences of the United States of America, 82 (19). pp. 6470-6474. ISSN 0027-8424. PMCID PMC390738. https://resolver.caltech.edu/CaltechAUTHORS:SOLpnas85

1983

Snapka, Robert M. and Varshavsky, Alexander (1983) Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea. Proceedings of the National Academy of Sciences of the United States of America, 80 (24). pp. 7533-7537. ISSN 0027-8424. PMCID PMC389986. https://resolver.caltech.edu/CaltechAUTHORS:SNApnas83

Barsoum, James and Varshavsky, Alexander (1983) Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes. Proceedings of the National Academy of Sciences of the United States of America, 80 (17). pp. 5330-5334. ISSN 0027-8424. PMCID PMC384249. https://resolver.caltech.edu/CaltechAUTHORS:BARpnas83

1982

Levinger, Louis and Varshavsky, Alexander (1982) Protein D1 preferentially binds A+T-rich DNA in vitro and is a component of Drosophila melanogaster nucleosomes containing A+T-rich satellite DNA. Proceedings of the National Academy of Sciences of the United States of America, 79 (23). pp. 7152-7156. ISSN 0027-8424. PMCID PMC347296. https://resolver.caltech.edu/CaltechAUTHORS:LEVpnas82

Boyce, Frederick M. and Sundin, Olof and Barsoum, James et al. (1982) New way to isolate simian virus 40 nucleoprotein complexes from infected cells: use of a thiol-specific reagent. Journal of Virology, 42 (1). pp. 292-296. ISSN 0022-538X. PMCID PMC256070. https://resolver.caltech.edu/CaltechAUTHORS:BOYjvir82

1981

Varshavsky, Alexander (1981) On the possibility of metabolic control of replicon "misfiring": Relationship to emergence of malignant phenotypes in mammalian cell lineages. Proceedings of the National Academy of Sciences of the United States of America, 78 (6). pp. 3673-3677. ISSN 0027-8424. PMCID PMC319633. https://resolver.caltech.edu/CaltechAUTHORS:VARpnas81

1980

Levinger, Louis and Varshavsky, Alexander (1980) High-resolution fractionation of nucleosomes: minor particles, "whiskers," and separation of mononucleosomes containing and lacking A24 semihistone. Proceedings of the National Academy of Sciences of the United States of America, 77 (6). pp. 3244-3248. ISSN 0027-8424. PMCID PMC349591. https://resolver.caltech.edu/CaltechAUTHORS:LEVpnas80

This list was generated on Tue Oct 15 20:46:56 2019 PDT.