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Published September 15, 2017 | Version Supplemental Material
Journal Article Open

A cargo-sorting DNA robot

Creators

Abstract

Single-stranded DNA robots can move over the surface of a DNA origami sheet and sort molecular cargoes. Thubagere et al. developed a simple algorithm for recognizing two types of molecular cargoes and their drop-off destinations on the surface (see the Perspective by Reif). The DNA robot, which has three modular functional domains, repeatedly picks up the two types of molecules and then places them at their target destinations. No additional power is required because the DNA robot does this by random walking across the origami surface.

Additional Information

© 2017 American Association for the Advancement of Science. We thank R. Murray, P. Rothemund, C. Thachuk, P. Yin, and R. Jungmann for discussions and suggestions. Z.C., S.D., Y.L.L., G.I., and S.W. were supported by Caltech Summer Undergraduate Research Fellowships. N.S., D.W., and E.W. were supported by an NSF Expedition in Computing (0832824). A.J.T. was supported by an NSF grant (1351081). W.L. was supported by an NSF Expedition in Computing (1317694). R.F.J. was supported by an NSF Graduate Research Fellowship. L.Q. was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund (1010684) and a Faculty Early Career Development Award from the NSF (1351081). All data are reported in the main text and the supplementary materials.

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Additional details

Identifiers

Eprint ID
79651
Resolver ID
CaltechAUTHORS:20170731-174213645

Funding

Caltech Summer Undergraduate Research Fellowship (SURF)
NSF
CCF-0832824
NSF
CCF-1351081
NSF
CCF-1317694
NSF Graduate Research Fellowship
Burroughs Wellcome Fund
1010684

Dates

Created
2017-09-14
Created from EPrint's datestamp field
Updated
2021-11-15
Created from EPrint's last_modified field