Using EPR To Compare PEG-branch-nitroxide "Bivalent-Brush Polymers" and Traditional PEG Bottle–Brush Polymers: Branching Makes a Difference
Abstract
Attachment of poly(ethylene glycol) (PEG) to polymeric nanostructures is a general strategy for sterically shielding and imparting water solubility to hydrophobic payloads. In this report, we describe direct graft-through polymerization of branched, multifunctional macromonomers that possess a PEG domain and a hydrophobic nitroxide domain. Electron paramagnetic resonance (EPR) spectroscopy was used to characterize microenvironments within these novel nanostructures. Comparisons were made to nitroxide-labeled, traditional bottle-brush random and block copolymers. Our results demonstrate that bivalent bottle-brush polymers have greater microstructural homogeneity compared to random copolymers of similar composition. Furthermore, we found that compared to a traditional brush polymer, the branched-brush, "pseudo-alternating" microstructure provided more rotational freedom to core-bound nitroxides, and greater steric shielding from external reagents. The results will impact further development of multivalent bottle-brush materials as nanoscaffolds for biological applications.
Additional Information
© 2012 American Chemical Society. Published In Issue October 23, 2012; Article ASAP: October 04, 2012; Received: September 06, 2012.Attached Files
Published - ma301874d.pdf
Supplemental Material - ma301874d_si_001.pdf
Files
Name | Size | Download all |
---|---|---|
md5:a9521490d9fc84ddd1d2f7bb60504e01
|
3.9 MB | Preview Download |
md5:19fe87c8fe50d64c1d54580fb28256d8
|
7.0 MB | Preview Download |
Additional details
- Eprint ID
- 35631
- Resolver ID
- CaltechAUTHORS:20121126-103324858
- Created
-
2012-11-26Created from EPrint's datestamp field
- Updated
-
2021-11-09Created from EPrint's last_modified field