CaltechAUTHORS
Published March 2015 | Version Published
Journal Article Open

Optical-resolution photoacoustic endomicroscopy in vivo

Creators

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the OR-PAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acoustic-resolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents.

Additional Information

© 2015 Optical Society of America. Received 10 Dec 2014; revised 26 Jan 2015; accepted 28 Jan 2015; published 23 Feb 2015. We thank Prof. James Ballard for his attentive reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 CA157277, DP1 EB016986 (NIH Director's Pioneer Award), P41-EB002182, and R01 CA186567 (NIH Director's Transformative Research Award). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. K.M. has a financial interest in Microphotoacoustics, Inc.

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Additional details

Identifiers

PMCID
PMC4361445
Eprint ID
68577
Resolver ID
CaltechAUTHORS:20160622-102632287

Funding

NIH
R01 CA157277
NIH
DP1 EB016986
NIH
P41-EB002182
NIH
R02 CA186567

Dates

Created
2016-06-23
Created from EPrint's datestamp field
Updated
2021-11-11
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