Published March 27, 1996
| Supplemental Material
Journal Article
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2'-Deoxy-3-isoadenosine Forms Hoogsteen-Type Base Pairs with Thymidine in the d(CG[iA]TCG)_2 Duplex^1
Abstract
Present-day genetic material, DNA and RNA, consists of five major nucleic acid bases (A, G, T, C, and U) and the sugar-phosphate backbone. In addition to the question of their selection from prebiotic matter, there are more subtle issues, including, in the case of purines, the site of attachment of ribose/deoxyribose at N9 versus N3. The reaction of adenine with protected sugar halides gives a mixture containing more or less equal amounts of N9 and N3 derivatives.
Additional Information
© 1996 American Chemical Society. Received December 12, 1995. Publication Date (Web): March 27, 1996. This work was supported by the NIH grant GM-41612 to A.H.-J.W. The Varian VXR500 NMR spectrometer was supported in part from the NIH shared instrumentation grant 1S10RR06243.Attached Files
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Additional details
- Eprint ID
- 81613
- DOI
- 10.1021/ja954178a
- Resolver ID
- CaltechAUTHORS:20170920-100849308
- NIH
- GM-41612
- NIH
- 1S10RR06243
- Created
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2017-09-20Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field