Cargo-Towing Fuel-Free Magnetic Nanoswimmers for Targeted Drug Delivery
Abstract
Fuel-free nanomotors are essential for future in-vivo biomedical transport and drug-delivery applications. Herein, the first example of directed delivery of drug-loaded magnetic polymeric particles using magnetically driven flexible nanoswimmers is described. It is demonstrated that flexible magnetic nickel–silver nanoswimmers (5–6 μm in length and 200 nm in diameter) are able to transport micrometer particles at high speeds of more than 10 μm s−1 (more than 0.2 body lengths per revolution in dimensionless speed). The fundamental mechanism of the cargo-towing ability of these magnetic (fuel-free) nanowire motors is modelled, and the hydrodynamic features of these cargo-loaded motors discussed. The effect of the cargo size on swimming performance is evaluated experimentally and compared to a theoretical model, emphasizing the interplay between hydrodynamic drag forces and boundary actuation. The latter leads to an unusual increase of the propulsion speed at an intermediate particle size. Potential applications of these cargo-towing nanoswimmers are demonstrated by using the directed delivery of drug-loaded microparticles to HeLa cancer cells in biological media. Transport of the drug carriers through a microchannel from the pick-up zone to the release microwell is further illustrated. It is expected that magnetically driven nanoswimmers will provide a new approach for the rapid delivery of target-specific drug carriers to predetermined destinations.
Additional Information
© 2012 Wiley. Received: September 14, 2011. Published online: December 15, 2011. This work was supported by the National Science Foundation (Award Number CBET-0853375 to JW, CBET-0746285 to EL and CMMI-1031239 to LZ) and the Croucher Foundation (through a scholarship to OSP). SC acknowledges the support from Programa Becas Complutense del Amo (2010-2011). The authors would like to acknowledge also K. Chan for helping the magnetic setup and Allen Pei, Adam Ponedal for assisting in the nanowires preparation.Attached Files
Supplemental Material - smll_201101909_sm_Movie001.wmv
Supplemental Material - smll_201101909_sm_Movie002.wmv
Supplemental Material - smll_201101909_sm_Movie003.wmv
Supplemental Material - smll_201101909_sm_suppl.pdf
Files
Additional details
- Eprint ID
- 84545
- Resolver ID
- CaltechAUTHORS:20180126-131405657
- CBET-0853375
- NSF
- CMMI-1031239
- NSF
- CMMI-1031239
- NSF
- Croucher Foundation
- Programa Becas Complutense del Amo (2010-2011)
- Created
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2018-01-31Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field