Neural circuits driving larval locomotion in Drosophila
Abstract
More than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions. What is less understood is how a group of neurons from disparate anterior-posterior axial positions, lineages and developmental periods of neurogenesis coalesce to form a functional circuit. Using neurogenetic techniques developed in Drosophila it is now possible to study the neural substrates of behavior at single cell resolution. New mapping tools described in this review, allow researchers to chart neural connectivity to better understand how an anatomically simple organism performs complex behaviors.
Additional Information
© 2018 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Received: 30 January 2018; Accepted: 5 April 2018; Published: 19 April 2018. This work was supported by the APS Porter Physiology Development Fellowship (M.Q.C.) and HHMI (C.Q.D). We thank Jan Trout and Hannah Read for producing the figures. Funding: Funded by NIH HD27056, T32HD007348–24, and T32GM007413–36. Authors' contributions: All authors wrote sections of the manuscript, and all authors approve the manuscript. Ethics approval and consent to participate: Not applicable (review paper). Consent for publication: I give consent for publication. All authors declare that they have no competing interests.Attached Files
Published - 10.1186_2Fs13064-018-0103-z.pdf
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Additional details
- PMCID
- PMC5907184
- Eprint ID
- 85973
- Resolver ID
- CaltechAUTHORS:20180419-100547175
- American Physiological Society
- Howard Hughes Medical Institute (HHMI)
- HD27056
- NIH
- T32HD007348-24
- NIH Predoctoral Fellowship
- T32GM007413-36
- NIH Predoctoral Fellowship
- Created
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2018-04-19Created from EPrint's datestamp field
- Updated
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2022-03-11Created from EPrint's last_modified field