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Published March 6, 2006 | Published
Book Section - Chapter Open

In vivo functional photoacoustic tomography of traumatic brain injury in rats


In this study, we demonstrate the potential of photoacoustic tomography for the study of traumatic brain injury (TBI) in rats in vivo. Based on spectroscopic photoacoustic tomography that can detect the absorption rates of oxy- and deoxy-hemoglobins, the blood oxygen saturation and total blood volume in TBI rat brains were visualized. Reproducible cerebral trauma was induced using a fluid percussion TBI device. The time courses of the hemodynamic response following the trauma initiation were imaged with multi-wavelength photoacoustic tomography with bandwidth-limited spatial resolution through the intact skin and skull. In the pilot set of experiments, trauma induced hematomas and blood oxygen saturation level changes were detected, a finding consistent with the known physiological responses to TBI. This new imaging method will be useful for future studies on TBI-related metabolic activities and the effects of therapeutic agents.

Additional Information

© 2006 Society of Photo-optical Instrumentation Engineers (SPIE). This research was supported in part by the National Institutes of Health grants R01 EB000712 and R01 NS46214. J.T. Oh was supported in part by the Post-doctoral Fellowship Program of Korea Science & Engineering Foundation (KOSEF).

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