Depth-resolved degree of polarization of backscattered light and two-dimensional Mueller matrices of biological tissue measured by optical coherence tomography
Mueller matrices provide a complete characterization of the optical polarization properties of biological tissue. A polarization-sensitive optical coherence tomography (OCT) system was built and used to investigate the optical polarization properties of biological tissues and other turbid media. The apparent degree of polarization (DOP) of the backscattered light was measured with both liquid and solid scattering samples. The DOP maintains the value of unity within the detectable depth for the solid sample while the DOP decreases with the optical depth for the liquid sample. Two-dimensional depth-resolved images of the full Mueller matrices of biological tissues were measured with this system. These polarization measurements revealed some tissue structures that are not perceptible with standard OCT.
Additional Information© 2001 Society of Photo-Optical Instrumentation Engineers (SPIE). Thanks to Dr. G. Stoica, College of Veterinary Medicine, Texas A&M University for providing the sample. This study was sponsored in part by National Institutes of Health grants R29 CA68562, R01 CA71980, and R21 CA83760, by National Science Foundation grant BES-9734491, and by Texas Higher Education Coordinating Board grant 000512-0123-1999.
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