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Published September 10, 2005 | Published
Journal Article Open

Fiber-based polarization-sensitive Mueller matrix optical coherence tomography with continuous source polarization modulation


We report on a new configuration of fiber-based polarization-sensitive Mueller matrix optical coherence tomography that permits the acquisition of the round-trip Jones matrix of a biological sample using only one light source and a single depth scan. In this new configuration, a polarization modulator is used in the source arm to continuously modulate the incident polarization state for both the reference and the sample arms. The Jones matrix of the sample can be calculated from the two frequency terms in the two detection channels. The first term is modulated by the carrier frequency, which is determined by the longitudinal scanning mechanism, whereas the other term is modulated by the beat frequency between the carrier frequency and the second harmonic of the modulation frequency of the polarization modulator. One important feature of this system is that, for the first time to our knowledge, the Jones matrix of the sample can be calculated with a single detection channel and a single measurement when diattenuation is negligible. The system was successfully tested by imaging both standard polarization elements and biological samples.

Additional Information

© 2005 Optical Society of America. Received 27 February 2004; revised manuscript received 14 February 2005; accepted 21 February 2005. This project was sponsored in part by National Institutes of Health grants EB00319-02 and CA092415.

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